Search Results - "GELEZIUNAS, Romas"

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys by Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Cadena, Anthony M., Yu, Wen-Han, Fischinger, Stephanie, Broge, Thomas, Abbink, Peter, Mercado, Noe B., Chandrashekar, Abishek, Jetton, David, Peter, Lauren, McMahan, Katherine, Moseley, Edward T., Bekerman, Elena, Hesselgesser, Joseph, Li, Wenjun, Lewis, Mark G., Alter, Galit, Geleziunas, Romas, Barouch, Dan H.

“…The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of…”
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B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers by Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A, Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I, Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M, Edlefsen, Paul T, Piatak, Michael, Estes, Jacob D, Lifson, Jeffrey D, Picker, Louis J

“…Fukazawa et al . report that SIV persists in follicular helper T cells in elite controller macaques, evading clearance by CD8+ T cells Chronic-phase HIV and…”
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TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy by Lim, So-Yon, Osuna, Christa E, Hraber, Peter T, Hesselgesser, Joe, Gerold, Jeffrey M, Barnes, Tiffany L, Sanisetty, Srisowmya, Seaman, Michael S, Lewis, Mark G, Geleziunas, Romas, Miller, Michael D, Cihlar, Tomas, Lee, William A, Hill, Alison L, Whitney, James B

“…Antiretroviral therapy (ART) can halt HIV-1 replication but fails to target the long-lived latent viral reservoir. Several pharmacological compounds have been…”
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PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy by Bekerman, Elena, Hesselgesser, Joseph, Carr, Brian, Nagel, Mark, Hung, Magdeleine, Wang, Adele, Stapleton, Lance, von Gegerfelt, Agneta, Elyard, Hanne Andersen, Lifson, Jeffrey D, Geleziunas, Romas

“…Antiretroviral therapy (ART) limits human immunodeficiency virus 1 (HIV-1) replication but does not eliminate the long-lived reservoir established shortly…”
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Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing by Wei, Datsen George, Chiang, Vicki, Fyne, Elizabeth, Balakrishnan, Mini, Barnes, Tiffany, Graupe, Michael, Hesselgesser, Joseph, Irrinki, Alivelu, Murry, Jeffrey P, Stepan, George, Stray, Kirsten M, Tsai, Angela, Yu, Helen, Spindler, Jonathan, Kearney, Mary, Spina, Celsa A, McMahon, Deborah, Lalezari, Jacob, Sloan, Derek, Mellors, John, Geleziunas, Romas, Cihlar, Tomas

“…Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation…”
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Origin of rebound virus in chronically SIV-infected Rhesus monkeys following treatment discontinuation by Liu, Po-Ting, Keele, Brandon F., Abbink, Peter, Mercado, Noe B., Liu, Jinyan, Bondzie, Esther A., Chandrashekar, Abishek, Borducchi, Erica N., Hesselgesser, Joseph, Mish, Michael, Chin, Gregory, Bekerman, Elena, Geleziunas, Romas, Barouch, Dan H.

“…Viral rebound following antiretroviral therapy (ART) discontinuation in HIV-1-infected individuals is believed to originate from a small pool of CD4+ T cells…”
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Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial by Bailón, Lucia, Llano, Anuska, Cedeño, Samandhy, Escribà, Tuixent, Rosás-Umbert, Miriam, Parera, Mariona, Casadellà, Maria, Lopez, Miriam, Pérez, Francisco, Oriol-Tordera, Bruna, Ruiz-Riol, Marta, Coll, Josep, Perez, Felix, Rivero, Àngel, Leselbaum, Anne R., McGowan, Ian, Sengupta, Devi, Wee, Edmund G., Hanke, Tomáš, Paredes, Roger, Alarcón-Soto, Yovaninna, Clotet, Bonaventura, Noguera-Julian, Marc, Brander, Christian, Molto, Jose, Mothe, Beatriz

“…HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV) vaccine immunogen designed to elicit cellular immune responses to HIV targets…”
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Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound by Okoye, Afam A., Hansen, Scott G., Vaidya, Mukta, Fukazawa, Yoshinori, Park, Haesun, Duell, Derick M., Lum, Richard, Hughes, Colette M., Ventura, Abigail B., Ainslie, Emily, Ford, Julia C., Morrow, David, Gilbride, Roxanne M., Legasse, Alfred W., Hesselgesser, Joseph, Geleziunas, Romas, Li, Yuan, Oswald, Kelli, Shoemaker, Rebecca, Fast, Randy, Bosche, William J., Borate, Bhavesh R., Edlefsen, Paul T., Axthelm, Michael K., Picker, Louis J., Lifson, Jeffrey D.

“…Prophylactic vaccination of rhesus macaques with rhesus cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV)…”
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TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption by Hsu, Denise C, Schuetz, Alexandra, Imerbsin, Rawiwan, Silsorn, Decha, Pegu, Amarendra, Inthawong, Dutsadee, Sopanaporn, Jumpol, Visudhiphan, Pornsuk, Chuenarom, Weerawan, Keawboon, Boot, Shi, Wei, Robb, Merlin L, Mascola, John R, Geleziunas, Romas, Koup, Richard A, Barouch, Dan H, Michael, Nelson L, Vasan, Sandhya

“…Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV…”
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Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy by Whitney, James B., Lim, So-Yon, Osuna, Christa E., Kublin, Jessica L., Chen, Elsa, Yoon, Gyeol, Liu, Po-Ting, Abbink, Peter, Borducci, Erica N., Hill, Alison, Lewis, Mark G., Geleziunas, Romas, Robb, Merlin L., Michael, Nelson L., Barouch, Dan H.

“…The precise time when the viral reservoir is seeded during acute HIV-1 infection remains unclear. We previously demonstrated that the viral reservoir was…”
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A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes by Jones, R Brad, Mueller, Stefanie, O'Connor, Rachel, Rimpel, Katherine, Sloan, Derek D, Karel, Dan, Wong, Hing C, Jeng, Emily K, Thomas, Allison S, Whitney, James B, Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J, Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P, Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A, Irvine, Darrell J, Walker, Bruce D

“…Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little…”
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Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation by Bricker, Katherine M, Obregon-Perko, Veronica, Uddin, Ferzan, Williams, Brianna, Uffman, Emilie A, Garrido, Carolina, Fouda, Genevieve G, Geleziunas, Romas, Robb, Merlin, Michael, Nelson, Barouch, Dan H, Chahroudi, Ann

“…Globally, 1.8 million children are living with HIV-1. While antiretroviral therapy (ART) has improved disease outcomes, it does not eliminate the latent HIV-1…”
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HIV envelope antibodies and TLR7 agonist partially prevent viral rebound in chronically SHIV-infected monkeys by Moldt, Brian, Chandrashekar, Abishek, Borducchi, Erica N, Nkolola, Joseph P, Stephenson, Heather, Nagel, Mark, Hung, Magdeleine, Goldsmith, Joshua, Pace, Craig S, Carr, Brian, Thomsen, Nathan D, Blair, Wade S, Geleziunas, Romas, Barouch, Dan H

“…A key challenge for the development of a cure to HIV-1 infection is the persistent viral reservoir established during early infection. Previous studies using…”
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Evaluation of Broadly Neutralizing Antibody Sensitivity by Genotyping and Phenotyping for Qualifying Participants to HIV Clinical Trials by Moldt, Brian, Parvangada, Aiyappa, Martin, Ross, Pace, Craig, Balakrishnan, Mini, Thomsen, Nathan D., E. Collins, Sean, Kuster, Herbert, Braun, Dominique L., Günthard, Huldrych F., Geleziunas, Romas, Callebaut, Christian

“…HIV envelope (env) diversity represents a significant challenge for the use of broadly neutralizing antibodies (bNAbs) in HIV treatment and cure studies…”
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Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques by Del Prete, Gregory Q, Smedley, Jeremy, Macallister, Rhonda, Jones, Gregg S, Li, Bei, Hattersley, Jillian, Zheng, Jim, Piatak, Jr, Michael, Keele, Brandon F, Hesselgesser, Joseph, Geleziunas, Romas, Lifson, Jeffrey D

“…The use of nonhuman primate (NHP) models to study persistent residual virus and viral eradication strategies in combination antiretroviral therapy…”
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Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques by Walker-Sperling, Victoria E. K., Mercado, Noe B., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Lewis, Mark, Murry, Jeffrey P., Yang, Yunling, Geleziunas, Romas, Robb, Merlin L., Michael, Nelson L., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Barouch, Dan H.

“…The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies have shown that therapeutic vaccination or broadly…”
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Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys by Boopathy, Archana V., Sharma, Bhawna, Nekkalapudi, Anurag, Wimmer, Raphaela, Gamez-Guerrero, Maria, Suthram, Silpa, Truong, Hoa, Lee, Johnny, Li, Jiani, Martin, Ross, Blair, Wade, Geleziunas, Romas, Orlinger, Klaus, Ahmadi-Erber, Sarah, Lauterbach, Henning, Makadzange, Tariro, Falkard, Brie, Schmidt, Sarah

“…HIV affects more than 38 million people worldwide. Although HIV can be effectively treated by lifelong combination antiretroviral therapy, only a handful of…”
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Arenavirus-Based Vectors Generate Robust SIV Immunity in Non-Human Primates by Sharma, Bhawna, Bekerman, Elena, Truong, Hoa, Lee, Johnny, Gamez-Guerrero, Maria, Boopathy, Archana, Mital, Rohit, Huang, Katell Bidet, Ahmadi-Erber, Sarah, Wimmer, Raphaela, Schulha, Sophie, Lauterbach, Henning, Orlinger, Klaus, Suthram, Silpa, Lewis, Mark G, Blair, Wade, Makadzange, Tariro, Geleziunas, Romas, Murry, Jeffrey P, Schmidt, Sarah

“…Arenavirus-based vectors are being investigated as therapeutic vaccine candidates with the potential to elicit robust CD8 T-cell responses. We compared the…”
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Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques by Ventura, John D., Nkolola, Joseph P., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Mercado, Noe B., Hope, David L., Giffin, Victoria M., McMahan, Katherine, Geleziunas, Romas, Murry, Jeffrey P., Yang, Yunling, Lewis, Mark G., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Robb, Merlin L., Michael, Nelson L., Barouch, Dan H.

“…Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure…”
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Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody by Luftig, Micah A, Miller, Michael D, Carfí, Andrea, Barbato, Gaetano, Di Giovine, Paolo, Pessi, Antonello, Hrin, Renee, Geleziunas, Romas, Bianchi, Elisabetta, Mattu, Marco

“…Elicitation of potent and broadly neutralizing antibodies is an important goal in designing an effective human immunodeficiency virus-1 (HIV-1) vaccine. The…”
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