Search Results - "GELBOIN, Harry V"

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology by Soars, Matthew G., Gelboin, Harry V., Krausz, Kristopher W., Riley, Robert J.

“…Aims The objective of this study was to evaluate the potential uses of relative abundance, relative activity approaches and inhibitory monoclonal antibodies…”
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4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine by Granvil, Camille P, Krausz, Kristopher W, Gelboin, Harry V, Idle, Jeffrey R, Gonzalez, Frank J

“…A panel of 15 recombinant cytochromes P450 expressed in human B-lymphoblastoid cells was used to study debrisoquine 4-hydroxylation. Both CYP2D6 and CYP1A1…”
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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions by Rettie, Allan E, Korzekwa, Kenneth R, Kunze, Kent L, Lawrence, Ross F, Eddy, A Craig, Aoyama, Toshifumi, Gelboin, Harry V, Gonzalez, Frank J, Trager, William F

“…Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in human liver microsomes which appears to be responsible for the…”
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Characterization of the common genetic defect in humans deficient in debrisoquine metabolism by Gonzalez, Frank J, Skodat, Radek C, Kimura, Shioko, Umeno, Morio, Zanger, Ulrich M, Nebert, Daniel W, Gelboin, Harry V, Hardwick, James P, Meyer, Urs A

“…In population studies of individuals given the antihypertensive drug debrisoquine, two distinct phenotypes have been described: extensive metabolizers excrete…”
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Monoclonal Antibodies Specific and Inhibitory to Human Cytochromes P450 2C8, 2C9, and 2C19 by KRAUSZ, Kristopher W, GOLDFARB, Inna, BUTERS, Jeroen T. M, YANG, Tian J, GONZALEZ, Frank J, GELBOIN, Harry V

“…Hybridomas were isolated that produce 13 monoclonal antibodies (mAbs) that are specific and highly inhibitory to members of the human P450 2C subfamily, 2C8,…”
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Role of cDNA-Expressed Human Cytochromes P450 in the Metabolism of Diazepam by Yang, Tian J, Shou, Magang, Korzekwa, Kenneth R, Gonzalez, Frank J, Gelboin, Harry V, Yang, Shen K

“…The metabolic conversion of diazepam (DZ) to temazepam (TMZ, a C3-hydroxylation product of DZ) and N-desmethyldiazepam (NDZ, an N1-demethylation product of DZ)…”
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Monoclonal Antibodies and Multifunctional Cytochrome P450: Drug Metabolism as Paradigm by Gelboin, Harry V., Krausz, Kristopher

“…Monoclonal antibodies are reagents par excellence for analyzing the role of individual cytochrome P450 isoforms in multifunctional biological activities…”
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Effect of Phenobarbital on Hepatic CYP1A1 and CYP1A2 in the Ahr-Null Mouse by Zaher, Hani, Yang, Tian J, Gelboin, Harry V, Fernandez-Salguero, Pedro, Gonzalez, Frank J

“…Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the…”
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cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver by Yamano, Shigeru, Nhamburo, Patson T, Aoyama, Toshifumi, Meyer, Urs A, Inaba, Tadanobu, Kalow, Werner, Gelboin, Harry V, McBride, O. Wesley, Gonzalez, Frank J

“…A cDNA designated hIIB1, representing the entire coding sequence of a P450 in the IIB gene family, was isolated from a human liver lambda gt11 library by using…”
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Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases by Niemelä, Onni, Parkkila, Seppo, Juvonen, Risto O, Viitala, Katja, Gelboin, Harry V, Pasanen, Markku

“…Background/Aims: Interaction between CYP2E1, ethanol metabolites, and enhanced lipid peroxidation is linked to the pathogenesis of alcoholic liver disease…”
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Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping by Nhamburo, Patson T, Gonzalez, Frank J, McBride, O. Wesley, Gelboin, Harry V, Kimura, Shioko

“…A cDNA coding for a P450 expressed in human lung was isolated from a lambda gt11 library constructed from human lung mRNA using a cDNA probe to rat P450 IVA1…”
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The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping by Nhamburo, Patson T, Kimura, Shioko, McBride, O. Wesley, Kozak, Christine A, Gelboin, Harry V, Gonzalez, Frank J

“…A cDNA coding for a P450, designated IIF1, was isolated from a human lung lambda gt11 library by screening with a human IIC9 cDNA probe. The cDNA-encoded IIF1…”
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Further characterization of the expression in liver and catalytic activity of CYP2B6 by Ekins, S, Vandenbranden, M, Ring, B J, Gillespie, J S, Yang, T J, Gelboin, H V, Wrighton, S A

“…Previous studies in this laboratory have determined the lack of specificity of several antibody and substrate probes of CYP2B6. The goals of the current study…”
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Identification of cytochromes P 450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro by Ufer, Mike, Svensson, Jan O., Krausz, Kristopher W., Gelboin, Harry V., Rane, Anders, Tybring, Gunnel

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Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro by UFER, Mike, SVENSSON, Jan O, KRAUSZ, Kristopher W, GELBOIN, Harry V, RANE, Anders, TYBRING, Gunnel

“…This in-vitro study aimed at an identification of cytochrome P(450) (CYP) enzymes catalysing the (S)- and (R)-hydroxylation of the widely used anticoagulant…”
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Enhancement of cardiac L-type Ca2+ currents in transgenic mice with cardiac-specific overexpression of CYP2J2 by Xiao, Yong-Fu, Ke, Qingen, Seubert, John M, Bradbury, J Alyce, Graves, Joan, Degraff, Laura M, Falck, John R, Krausz, Kris, Gelboin, Harry V, Morgan, James P, Zeldin, Darryl C

“…CYP2J2 is abundant in cardiomyocytes and is involved in the metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs), which affect multiple cell…”
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Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats by Elovaara, Eivor, Stockmann-Juvala, Helene, Mikkola, Jouni, Gelboin, Harry V

“…Abstract The abilities of the gasoline additives methyl tert -butyl ether (MTBE) and tert -amyl methyl ether (TAME) to cause liver damage following oral…”
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The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes by Chou, Yueh-Ching, Chung, Yu-Ting, Liu, Tsung-Yun, Wang, Szu-Yu, Chau, Gar-Yang, Chi, Chin-Wen, Soucek, Pavel, Krausz, Kristopher W, Gelboin, Harry V, Lee, Chen-Hsen, Ueng, Yune-Fang

“…To characterize the human cytochrome P450 (P450) forms involved in dimemorfan oxidation (DFO), human liver microsomes, and recombinant P450s were investigated…”
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Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins by Gonzalez, F J, Gelboin, H V

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Inhibitory and Noninhibitory Monoclonal Antibodies to Human Cytochrome P450 2E1 by Gelboin, Harry V, Goldfarb, Inna, Krausz, Kristopher W, Grogan, James, Korzekwa, Kenneth R, Gonzalez, Frank J, Shou, Magang

“…A panel of 17 hybridomas producing (MAbs) against human cytochrome P450 2E1 (h2E1) was generated by immunizing mice with baculovirus-expressed h2E1. All 17…”
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