Search Results - "GELBERT, L"

Optimized blood cell profiling method for genomic biomarker discovery using high-density microarray by Shou, J., Dotson, C., Qian, H.-R., Tao, W., Lin, C., Lawrence, F., N'Cho, M., Kulkarni, N. H., Bull, C. M., Gelbert, L. M., Onyia, J. E.

“…Abstract High-quality biomarkers for disease progression, drug efficacy and toxicity liability are essential for improving the efficiency of drug discovery and…”
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Mutational analysis of patients with adenomatous polyposis : identical inactivating mutations in unrelated individuals by GRODEN, J, GELBERT, L, LEPPERT, M, WHITE, R, THLIVERIS, A, NELSON, L, ROBERTSON, M, JOSLYN, G, SAMOWITZ, W, SPIRIO, L, CARLSON, M, BURT, R

“…Samples of constitutional DNA from 60 unrelated patients with adenomatous polyposis coli (APC) were examined for mutations in the APC gene. Five inactivating…”
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Isolation and Characterization of Microsatellite Loci for Use in Population Genetic Analysis in the Timber Rattlesnake, Crotalus horridus by Villarreal, X., Bricker, J., Reinert, H. K., Gelbert, L., Bushar, L. M.

“…A Crotalus horridus genomic library was screened for clones containing microsatellite loci by hybridization with oligonucleotides consisting of a (dC × dA)n…”
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Gene Expression Profile of Antithrombotic Protein C Defines New Mechanisms Modulating Inflammation and Apoptosis by Joyce, David E., Gelbert, Larry, Ciaccia, Angelina, DeHoff, Brad, Grinnell, Brian W.

“…Human protein C is a natural anticoagulant factor, and a recombinant activated form of the molecule (rhAPC) is completing clinical evaluation for treatment of…”
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Long-range physical map and deletion characterization of the 1100-kb NotI restriction fragment harboring the APC gene by Thliveris, A, Albertsen, H, Tuohy, T, Carlson, M, Groden, J, Joslyn, G, Gelbert, L, Samowitz, W, Spirio, L, White, R

“…Adenomatous polyposis coli (APC) is an autosomal dominant inherited disorder manifested by early onset of numerous adenomatous polyps and an increased…”
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Chromosomal localization of the parathyroid hormone/parathyroid hormone-related protein receptor gene to human chromosome 3p21.1-p24.2 by Gelbert, L, Schipani, E, Jüppner, H, Abou-Samra, A B, Segre, G V, Naylor, S, Drabkin, H, Heath, 3rd, H

“…The human PTH/PTH-related peptide (PTH/PTHrP) receptor could be involved in hereditary disorders of PTH or PTHrP action. Knowledge of the gene's chromosomal…”
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A Sensitive Molecular Assay for Mutagenesis in Mammalian Cells: Reversion Analysis in Cells with a Mutant Shuttle Vector Gene Integrated into Chromosomal DNA by Gelbert, Lawrence M., Davidson, Richard L.

“…We have developed a system for the molecular analysis of mutations in mammalian cells. This system is based upon the use of mammalian cell lines containing…”
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ET-25 THERAPEUTIC MODULATION OF MDM2 IN NEUROBLASTOMA by Kania, K., Pollok, K., Gelbert, L., Shannon, H., Bailey, B., Batuello, C.

“…Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In high-risk NB, the MYCN gene is amplified in approximately 25% of all cases, and…”
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Will genetics really revolutionize the drug discovery process? by Gelbert, Lawrence M, Gregg, Richard E

“…Genetics has played only a modest role in drug discovery, but new technologies will radically change this. Whole genome sequencing will identify new drug…”
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PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes by VELASCO-MIGUEL, S, BUCKBINDER, L, JEAN, P, GELBERT, L, TALBOTT, R, LAIDLAW, J, SEIZINGER, B, KLEY, N

“…Exposure of mammalian cells to hypoxia, radiation and certain chemotherapeutic agents promotes cell cycle arrest and/or apoptosis. Activation of p53 responsive…”
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Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray by Onyia, Jude E., Helvering, Leah M., Gelbert, Lawrence, Wei, Tao, Huang, Shuguang, Chen, Peining, Dow, Ernst R., Maran, Avudaiappan, Zhang, Minzhi, Lotinun, Sutada, Lin, Xi, Halladay, David L., Miles, Rebecca R., Kulkarni, Nalini H., Ambrose, Emily M., Ma, Yanfei L., Frolik, Charles A., Sato, Masahiko, Bryant, Henry U., Turner, Russell T.

“…Teriparatide, human PTH (1‐34), a new therapy for osteoporosis, elicits markedly different skeletal responses depending on the treatment regimen. In order to…”
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Alleles of the APC gene: an attenuated form of familial polyposis by Spirio, L, Olschwang, S, Groden, J, Robertson, M, Samowitz, W, Joslyn, G, Gelbert, L, Thliveris, A, Carlson, M, Otterud, B

“…An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer…”
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Identification and characterization of the familial adenomatous polyposis coli gene by Groden, J, Thliveris, A, Samowitz, W, Carlson, M, Gelbert, L, Albertsen, H, Joslyn, G, Stevens, J, Spirio, L, Robertson, M

“…DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb…”
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Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer by CLAUDIO, P. P, HOWARD, C. M, TOSI, G. M, HICHELI, P, CAPUTI, M, GIORDANO, G. G, GIORDANO, A, PACILIO, C, CINTI, C, ROMANO, G, MINIMO, C, MARALDI, N. M, MINNA, J. D, GELBERT, L, LEONCINI, L

“…The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the…”
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Analysis of GPT activity in mammalian cells with a chromosomally integrated shuttle vector containing altered gpt genes by GELBERT, L. M, WILSON, M. M, DAVIDSON, R. L

“…The molecular mechanisms of reversion in mammalian cells were studied utilizing the pZipGptNeo shuttle vector, with the bacterial gpt gene in the vector…”
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Identification of deletion mutations and three new genes at the familial polyposis locus by Joslyn, G, Carlson, M, Thliveris, A, Albertsen, H, Gelbert, L, Samowitz, W, Groden, J, Stevens, J, Spirio, L, Robertson, M

“…Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate…”
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Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma by WHALEY, J. M, NAGLICH, J, KLEIN-SZANTO, A. J. P, SEIZINGER, B. R, KLEY, N, GELBERT, L, HSIA, Y. E, LAMIELL, J. M, GREEN, J. S, COLLINS, D, NEUMANN, H. P. H, LAIDLAW, J, LI, F. P

“…von Hippel-Lindau (VHL) disease is a hereditary tumor syndrome predisposing to multifocal bilateral renal cell carcinomas (RCCs), pheochromocytomas, and…”
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An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines by DAVIDSON, Jennifer D, LIANDONG MA, FLAGELLA, Michael, GEEGANAGE, Sandaruwan, GELBERT, Lawrence M, SLAPAK, Christopher A

“…The mechanisms of resistance to the antimetabolite gemcitabine in non-small cell lung cancer have not been extensively evaluated. In this study, we report the…”
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The p53 Tumor Suppressor Targets a Novel Regulator of G Protein Signaling by Buckbinder, Leonard, Velasco-Miguel, Susana, Chen, Yan, Xu, Ningzhi, Talbott, Randy, Gelbert, Larry, Gao, Jizong, Seizinger, Bernd R., Gutkind, J. Silvio, Kley, Nikolai

“…Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or…”
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Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis by Paul, P, Letteboer, T, Gelbert, L, Groden, J, White, R, Coppes, M J

“…Germ-line mutations in the adenomatous polyposis coli (APC) gene result in familial adenomatous polyposis coli (APC), an inherited syndrome that predisposes…”
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