Search Results - "GEISSLER, E. K"

Immunosuppression for liver transplantation by Geissler, E K, Schlitt, H J

“…In the last few decades liver transplantation (LTx) has become a reliable life-saving procedure for patients with chronic end-stage liver diseases. LTx has an…”
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Extrahepatic Bile Duct Organoids as a Model to Study Ischemia/Reperfusion Injury During Liver Transplantation by Kreiner, P, Eggenhofer, E, Schneider, L, Rejas, C, Goetz, M, Bogovic, N, Brunner, S M, Evert, K, Schlitt, H J, Geissler, E K, Junger, H

“…Biliary complications are still a major cause for morbidity and mortality after liver transplantation (LT). Ischemia/reperfusion injury (IRI) leads to…”
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EnGraft: a multicentre, open-label, randomised, two-arm, superiority study protocol to assess bioavailability and practicability of Envarsus® versus Advagraf™ in liver transplant recipients by Wöhl, D S, James, B, Götz, M, Brennfleck, F, Holub-Hayles, I, Mutzbauer, I, Baccar, S, Brunner, S M, Geissler, E K, Schlitt, H J

“…Graft rejection and chronic CNI toxicity remain obstacles to organ transplant success. Current formulations of tacrolimus, such as Prograf® and Advagraf™,…”
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Extracellular Citrate in Health and Disease by Mycielska, M E, Milenkovic, V M, Wetzel, C H, Rümmele, P, Geissler, E K

“…Citrate is one of the major substrates for intracellular metabolism. The extracellular level of citrate is stable in blood but varies locally, with slightly…”
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Mesenchymal Stem Cells Require a Sufficient, Ongoing Immune Response to Exert Their Immunosuppressive Function by Renner, P, Eggenhofer, E, Rosenauer, A, Popp, F.C, Steinmann, J.F, Slowik, P, Geissler, E.K, Piso, P, Schlitt, H.J, Dahlke, M.H

“…Abstract Mesenchymal stem cells (MSC) have emerged to be one of the most promising candidates for cellular immunotherapy in solid organ transplantation because…”
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Inhibition of Innate Co‐Receptor TREM‐1 Signaling Reduces CD4+ T Cell Activation and Prolongs Cardiac Allograft Survival by Schiechl, G., Brunner, S. M., Kesselring, R., Martin, M., Ruemmele, P., Mack, M., Hirt, S. W., Schlitt, H. J., Geissler, E. K., Fichtner‐Feigl, S.

“…The innate receptor “triggering‐receptor‐expressed‐on‐myeloid‐cells‐1” (TREM‐1) enhances downstream signaling of “pattern recognition receptor” (PRR) molecules…”
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Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis by de Gruijl, F.R., Koehl, G.E., Voskamp, P., Strik, A., Rebel, H.G., Gaumann, A., de Fijter, J.W., Tensen, C.P., Bavinck, J.N. Bouwes, Geissler, E.K.

“…Increased skin cancer risk in organ transplant recipients has been experimentally emulated with enhanced UV carcinogenesis from administering conventional…”
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Can Immunosuppressive Strategies Be Used to Reduce Cancer Risk in Renal Transplant Patients? by Geissler, E.K

“…Abstract The risk of renal transplant recipients developing a malignancy is increasingly recognized as a major issue impacting long-term overall survival. As…”
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Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset by Voskamp, P., Bodmann, C.A., Rebel, H.G., Koehl, G.E., Tensen, C.P., Bouwes Bavinck, J.N., El Ghalbzouri, A., Van Kranen, H.J., Willemze, R., Geissler, E.K., De Gruijl, F.R.

“…Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In…”
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Cytokines mediating the induction of chronic colitis and colitis-associated fibrosis by Fichtner-Feigl, S, Strober, W, Geissler, E K, Schlitt, H-J

“…To investigate the immunopathogenesis of inflammation-associated fibrosis we analyzed the chronic colitis and late-developing fibrosis occurring in BALB/c mice…”
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The Impact of mTOR Inhibitors on the Development of Malignancy by Geissler, E.K

“…Abstract Although continuous improvements have been made in fighting rejection with immunosuppressive drugs in transplant recipients, this success story has…”
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Fighting Malignancy in Organ Transplant Recipients by Geissler, E.K

“…Abstract The development of malignancy in immunosuppressed organ transplant recipients has recently gained increasing attention. Increased awareness of this…”
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Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion by Eggenhofer, E, Benseler, V, Kroemer, A, Popp, F C, Geissler, E K, Schlitt, H J, Baan, C C, Dahlke, M H, Hoogduijn, M J

“…Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of disorders. Although animal models show long term regenerative and…”
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Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice by Koehl, G E, Spitzner, M, Ousingsawat, J, Schreiber, R, Geissler, E K, Kunzelmann, K

“…The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis. Mice with a heterozygous APC Min mutation develop multiple intestinal…”
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Short‐term treatment with anti‐CD44v7 antibody, but not CD44v4, restores the gut mucosa in established chronic dextran sulphate sodium (DSS)‐induced colitis in mice by Farkas, S., Hornung, M., Sattler, C., Anthuber, M., Gunthert, U., Herfarth, H., Schlitt, H. J., Geissler, E. K., Wittig, B. M.

“…Summary Increased expression of CD44 variant isoforms have been shown on the inflammatory infiltrates in human and mouse colitis and blockade or deletion of…”
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Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development by Schiechl, G., Hermann, F. J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K., Brühl, H., Karasuyama, H., Obata‐Ninomiya, K., Utpatel, K., Evert, M., Hirt, S. W., Geissler, E. K., Fichtner‐Feigl, S., Mack, M.

“…Fibrosis is a major component of chronic cardiac allograft rejection. Although several cell types are able to produce collagen, resident (donor‐derived)…”
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mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma by Scheller, T, Hellerbrand, C, Moser, C, Schmidt, K, Kroemer, A, Brunner, S M, Schlitt, H J, Geissler, E K, Lang, S A

“…Background: Systemic therapy has proven only marginal effects in hepatocellular carcinoma (HCC) so far. The aim of this study was to evaluate the effect of…”
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Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC mice by Koehl, G E, Spitzner, M, Ousingsawat, J, Schreiber, R, Geissler, E K, Kunzelmann, K

“…The adenomatous polyposis coli (APC) gene is mutated in familial adenomatous polyposis. Mice with a heterozygous APC(Min) mutation develop multiple intestinal…”
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Prolongation of heart allograft survival after long-term expression of soluble MHC class I antigens and vIL-10 in the liver by AAV-plasmid-mediated gene transfer by Doenecke, A., Frank, E., Scherer, M. N., Schlitt, H.-J., Geissler, E. K.

“…Introduction The essential prerequisite for successful gene therapy in vivo is an effective and long-lasting transfer of the desired gene into the respective…”
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Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate by Popp, F.C, Eggenhofer, E, Renner, P, Slowik, P, Lang, S.A, Kaspar, H, Geissler, E.K, Piso, P, Schlitt, H.J, Dahlke, M.H

“…Abstract The induction of tolerance towards allogeneic solid organ grafts is one of the major goals in transplantation medicine. Mesenchymal stem cells (MSC)…”
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