Search Results - "GEHAN, Edmund"

The properties of high-dimensional data spaces: implications for exploring gene and protein expression data by Clarke, Robert, Ressom, Habtom W, Wang, Antai, Xuan, Jianhua, Liu, Minetta C, Gehan, Edmund A, Wang, Yue

“…Key Points The application of several high-throughput genomic and proteomic technologies to address questions in cancer diagnosis, prognosis and prediction…”
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Paroxetine Is an Effective Treatment for Hot Flashes: Results From a Prospective Randomized Clinical Trial by STEARNS, Vered, SLACK, Rebecca, HAYES, Daniel F, ISAACS, Claudine, CREEP, Nancy, HENRY-TILMAN, Ronda, OSBORNE, Michael, BUNNELL, Craig, ULLMER, Lynda, GALLAGHER, Ann, CULLEN, Jennifer, GEHAN, Edmund

“…In an open-label trial we have previously demonstrated that paroxetine reduces hot flashes. We initiated a stratified, randomized, double-blind, cross-over,…”
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Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence by HONGZHEN LI, YING ZHANG, GLASS, Andrew, ZELLWEGER, Tobias, GEHA, Edmund, BUBENDORF, Lukas, GELMANN, Edward P, NEVALAINEN, Marja T

“…Purpose: We have shown previously that the signal transducer and activator of transcription-5 (Stat5) is a critical survival factor in human prostate cancer…”
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Gene selection for microarray data analysis using principal component analysis by Wang, Antai, Gehan, Edmund A.

“…Principal component analysis (PCA) has been widely used in multivariate data analysis to reduce the dimensionality of the data in order to simplify subsequent…”
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Cyberknife radiosurgery for breast cancer spine metastases : A matched-pair analysis by GAGNON, Gregory J, HENDERSON, Fraser C, GEHAN, Edmund A, SANFORD, Donna, COLLINS, Brian T, MOULDS, Jefferson C, DRITSCHILO, Anatoly

“…There are few options for breast cancer patients with spinal metastases recurrent within a previous radiation treatment field. CyberKnife radiosurgery has been…”
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Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers by Cotarla, Ion, Ren, Shuxun, Zhang, Ying, Gehan, Edmund, Singh, Baljit, Furth, Priscilla A.

“…Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that are activated and translocated into the nucleus…”
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Phase I Study in Advanced Cancer Patients of a Diversified Prime-and-Boost Vaccination Protocol Using Recombinant Vaccinia Virus and Recombinant Nonreplicating Avipox Virus to Elicit Anti–Carcinoembryonic Antigen Immune Responses by MARSHALL, John L, HOYER, Robert J, TSANG, Kwong Y, SCHLOM, Jeffrey, TOOMEY, Mary Ann, FARAGUNA, Kristen, PING CHANG, RICHMOND, Ellen, PEDICANO, James E, GEHAN, Edmund, PECK, Ronald A, ARLEN, Philip

“…This trial sought to determine, for the first time, the validity in human vaccinations of using two different recombinant vaccines in diversified…”
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The 6-MP versus placebo clinical trial in acute leukemia by Gehan, Edmund A, Freireich, Emil J

“…Background This article gives the status of clinical cancer research in the 1950's–1960's and tells the story of the development and conduct of the…”
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Will There Be Resistance to the RECIST (Response Evaluation Criteria in Solid Tumors)? by Gehan, Edmund A., Tefft, Mariella C.

“…Since the 1950s, there have been concerns about the definition of response in solid tumors and the reliance on quantitative measurements. Gehan and Tefft…”
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Treatment–subgroup interaction: An example from a published, phase II clinical trial by Behrendt, Carolyn E, Gehan, Edmund A

“…Abstract Phase II trial designs that ignore between-patient heterogeneity and do not allow for treatment–subgroup interactions may produce very large false…”
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5.6 Ofatumumab and Bendamustine in Previously Treated CLL and SLL by Ujjani, Chaitra S, Ramzi, Pari, Gehan, Edmund A, Broome, Catherine M, Cheson, Bruce D

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5.5 Bendamustine and Lenalidomide in Relapsed/Refractory CLL by Ujjani, Chaitra S, Karim, Syed M, Goswami, Trishna, Crawford, Jenny, Gehan, Edmund A, Kessler, Craig, Cheson, Bruce D

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The development of novel agents for the treatment of colorectal cancer: a critical review of current practice and some suggestions for the future by Marshall, John L, Gehan, Edmund A

“…The pathways to approval of new therapeutic agents in the United States and globally rely on the performance of well-designed clinical trials demonstrating…”
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SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas by Kumar, Deepak, Sakabe, Isamu, Patel, Sonal, Zhang, Ying, Ahmad, Imran, Gehan, Edmund A, Whiteside, Theresa L, Kasid, Usha

“…We report here the identification and an initial characterization of a novel cell cycle-regulated molecule, SCC-112. SCC-112 cDNA (6744 bp) encodes a longest…”
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Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification--an Intergroup Rhabdomyosarcoma Study by Newton, Jr, W A, Gehan, E A, Webber, B L, Marsden, H B, van Unnik, A J, Hamoudi, A B, Tsokos, M G, Shimada, H, Harms, D, Schmidt, D

“…There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and…”
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Ofatumumab and bendamustine in previously treated chronic lymphocytic leukemia and small lymphocytic lymphoma by Ujjani, Chaitra, Ramzi, Pari, Gehan, Edmund, Wang, Hongkun, Wang, Yiru, Cheson, Bruce D.

“…Abstract Despite initial responses > 90% with fludarabine and rituximab-based regimens, patients with chronic lymphocytic leukemia (CLL) invariably relapse and…”
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Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroup Ewing's sarcoma studies by Cangir, A, Vietti, T J, Gehan, E A, Burgert, Jr, E O, Thomas, P, Tefft, M, Nesbit, M E, Kissane, J, Pritchard, D

“…Two Pediatric Intergroup Ewing's Sarcoma studies of patients with metastatic disease (IESS-MD) have used multimodal therapy consisting of intensive combination…”
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Radiation therapy for rhabdomyosarcoma: local failure risk for Clinical Group III patients on Intergroup Rhabdomyosarcoma Study II by Wharam, M D, Hanfelt, J J, Tefft, M C, Johnston, J, Ensign, L G, Breneman, J, Donaldson, S S, Fryer, C, Gehan, E A, Raney, R B, Maurer, H M

“…A subset of 362 pediatric patients with rhabdomyosarcoma was selected from a total of 532 eligible IRS-II patients in Clinical Group III to assess the local…”
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Abstract B74: Effects of a culturally targeted physician communication intervention on colorectal cancer screening among older Chinese American patients by Wang, Judy Huei-yu, Ma, Grace X., Liang, Wenchi, Gehan, Edmund, Tan, Yin, MaKambi, Kepher, Wang, Yiru, Vernon, Sally W., Tu, Shin-Ping, Mandelblatt, Jeanne

“…Abstract Asian Americans have much lower colorectal cancer (CRC) screening rates than other ethnic groups, even after controlling for access and language…”
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Lenalidomide Following Rituximab and Fludarabine in Untreated CLL by Ujjani, Chaitra S., Gehan, Edmund, Jamshed, Saad, Crawford, Jeanette, Broome, Catherine, Cohen, Philip, Cheson, Bruce D.

“…Abstract 3924 Current front-line regimens for previously untreated CLL typically include fludarabine (F) and rituximab (R), with or without cyclophosphamide,…”
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