Search Results - "GEE, W"

DprA-Dependent Exit from the Competent State Regulates Multifaceted Streptococcus pneumoniae Virulence by Lin, Jingjun, Lau, Gee W

“…(pneumococcus) causes multiple infectious diseases. The pneumococcal competence system facilitates genetic transformation, spreads antibiotic resistance, and…”
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Inhibition of competence development, horizontal gene transfer and virulence in Streptococcus pneumoniae by a modified competence stimulating peptide by Zhu, Luchang, Lau, Gee W

“…Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated…”
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Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae by Yang, Yifang, Lin, Jingjun, Harrington, Anthony, Cornilescu, Gabriel, Lau, Gee W., Tal-Gan, Yftah

“…Streptococcus pneumoniae is an opportunistic human pathogen that utilizes the competence regulon, a quorum-sensing circuitry, to acquire antibiotic resistance…”
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Inactivation of FOXA2 by Respiratory Bacterial Pathogens and Dysregulation of Pulmonary Mucus Homeostasis by Choi, Woosuk, Choe, Shawn, Lau, Gee W

“…Forkhead box (FOX) proteins are transcriptional factors that regulate various cellular processes. This minireview provides an overview of FOXA2 functions, with…”
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An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence by Morin, Charles D., Déziel, Eric, Gauthier, Jeff, Levesque, Roger C., Lau, Gee W.

“…Driven in part by its metabolic versatility, high intrinsic antibiotic resistance, and a large repertoire of virulence factors, Pseudomonas aeruginosa is…”
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Truly monolithic algebraic multigrid for fluid-structure interaction by Gee, M. W., Küttler, U., Wall, W. A.

“…The coupling of flexible structures to incompressible fluids draws a lot of attention during the last decade. Many different solution schemes have been…”
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Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch by Motika, Stephen E, Ulrich, Rebecca J, Geddes, Emily J, Lee, Hyang Yeon, Lau, Gee W, Hergenrother, Paul J

“…Multidrug-resistant Gram-negative (GN) infections for which there are few available treatment options are increasingly common. The development of new…”
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Attenuating the Streptococcus pneumoniae Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs by Lella, Muralikrishna, Oh, Myung Whan, Kuo, Shanny Hsuan, Lau, Gee W., Tal-Gan, Yftah

“…Streptococcus pneumoniae (pneumococcus) is a prevalent human pathogen that utilizes the competence regulon quorum sensing circuitry to acquire antibiotic…”
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Signal recognition particle RNA is critical for genetic competence and virulence of Streptococcus pneumoniae by Lin, Jingjun, Chong, Sook Yin, Oh, Myung Whan, Lew, Shi Qian, Zhu, Luchang, Zhang, Xuejin, Witola, William H, Lau, Gee W

“…(pneumococcus) causes a wide range of important human infectious diseases, including pneumonia, pneumonia-derived sepsis, otitis media, and meningitis…”
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Biomechanical rupture risk assessment of abdominal aortic aneurysms using clinical data: A patient-specific, probabilistic framework and comparative case-control study by Bruder, Lukas, Pelisek, Jaroslav, Eckstein, Hans-Henning, Gee, Michael W

“…We present a data-informed, highly personalized, probabilistic approach for the quantification of abdominal aortic aneurysm (AAA) rupture risk. Our novel…”
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Towards efficient uncertainty quantification in complex and large-scale biomechanical problems based on a Bayesian multi-fidelity scheme by Biehler, Jonas, Gee, Michael W., Wall, Wolfgang A.

“…In simulation of cardiovascular processes and diseases patient-specific model parameters, such as constitutive properties, are usually not easy to obtain…”
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An Endogenous Carbon-Sensing Pathway Triggers Increased Auxin Flux and Hypocotyl Elongation by Lilley, Jodi L. Stewart, Gee, Christopher W., Sairanen, Ilkka, Ljung, Karin, Nemhauser, Jennifer L.

“…The local environment has a substantial impact on early seedling development. Applying excess carbon in the form of sucrose is known to alter both the timing…”
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Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer by Achinger-Kawecka, Joanna, Valdes-Mora, Fatima, Luu, Phuc-Loi, Giles, Katherine A., Caldon, C. Elizabeth, Qu, Wenjia, Nair, Shalima, Soto, Sebastian, Locke, Warwick J., Yeo-Teh, Nicole S., Gould, Cathryn M., Du, Qian, Smith, Grady C., Ramos, Irene R., Fernandez, Kristine F., Hoon, Dave S., Gee, Julia M. W., Stirzaker, Clare, Clark, Susan J.

“…Endocrine therapy resistance frequently develops in estrogen receptor positive (ER+) breast cancer, but the underlying molecular mechanisms are largely…”
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A Gram-negative-selective antibiotic that spares the gut microbiome by Muñoz, Kristen A., Ulrich, Rebecca J., Vasan, Archit K., Sinclair, Matt, Wen, Po-Chao, Holmes, Jessica R., Lee, Hyang Yeon, Hung, Chien-Che, Fields, Christopher J., Tajkhorshid, Emad, Lau, Gee W., Hergenrother, Paul J.

“…Infections caused by Gram-negative pathogens are increasingly prevalent and are typically treated with broad-spectrum antibiotics, resulting in disruption of…”
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Disentangling competence for genetic transformation and virulence in Streptococcus pneumoniae by Lin, Jingjun, Zhu, Luchang, Lau, Gee W.

“…Horizontal gene transfer mediated by the competence regulon is a major driver of genome plasticity in Streptococcus pneumoniae. When pneumococcal cells enter…”
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Development of a Dominant Negative Competence‐Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia by Koirala, Bimal, Lin, Jingjun, Lau, Gee W., Tal‐Gan, Yftah

“…Streptococcus pneumoniae (pneumococcus) is a prevalent human pathogen responsible for a variety of diseases, including pneumonia, bacteremia, sepsis,…”
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Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt by Jin, Zhigang, Chung, Jin Wei, Mei, Wenyan, Strack, Stefan, He, Chunyan, Lau, Gee W, Yang, Jing

“…Recent genome-wide association studies reveal that the FAM13A gene is associated with human lung function and a variety of lung diseases, including chronic…”
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Mycoplasma pneumoniae modulates STAT3-STAT6/EGFR-FOXA2 signaling to induce overexpression of airway mucins by Hao, Yonghua, Kuang, Zhizhou, Jing, Jia, Miao, Jinfeng, Mei, Li Yu, Lee, Ryan J, Kim, Susie, Choe, Shawn, Krause, Duncan C, Lau, Gee W

“…Aberrant mucin secretion and accumulation in the airway lumen are clinical hallmarks associated with various lung diseases such as asthma, chronic obstructive…”
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Implicating the red body of Nannochloropsis in forming the recalcitrant cell wall polymer algaenan by Gee, Christopher W., Andersen-Ranberg, Johan, Boynton, Ethan, Rosen, Rachel Z., Jorgens, Danielle, Grob, Patricia, Holman, Hoi-Ying N., Niyogi, Krishna K.

“…Stramenopile algae contribute significantly to global primary productivity, and one class, Eustigmatophyceae, is increasingly studied for applications in…”
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Streptococcus pneumoniae Elaborates Persistent and Prolonged Competent State during Pneumonia-Derived Sepsis by Lin, Jingjun, Park, Pyunghun, Li, Hua, Oh, Myung Whan, Dobrucki, Iwona T, Dobrucki, Wawrzyniec, Lau, Gee W

“…The competence regulon of pneumococcus regulates both genetic transformation and virulence. However, competence induction during host infection has not been…”
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