Search Results - "GEE, L L"

Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis by Bajaj, Teena, Kuriyan, John, Gee, Christine L

“…Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein…”
Get full text

A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis by Pimentel, Harold, Parra, Marilyn, Gee, Sherry L, Mohandas, Narla, Pachter, Lior, Conboy, John G

“…Differentiating erythroblasts execute a dynamic alternative splicing program shown here to include extensive and diverse intron retention (IR) events. Cluster…”
Get full text

Structural basis and regulation of the reductive stress response by Manford, Andrew G., Mena, Elijah L., Shih, Karen Y., Gee, Christine L., McMinimy, Rachael, Martínez-González, Brenda, Sherriff, Rumi, Lew, Brandon, Zoltek, Madeline, Rodríguez-Pérez, Fernando, Woldesenbet, Makda, Kuriyan, John, Rape, Michael

“…Although oxidative phosphorylation is best known for producing ATP, it also yields reactive oxygen species (ROS) as invariant byproducts. Depletion of ROS…”
Get full text

Adipose Tissue: The New Endocrine Organ? A Review Article by Wozniak, Susan E, Gee, Laura L, Wachtel, Mitchell S, Frezza, Eldo E

“…Fat is either white or brown, the latter being found principally in neonates. White fat, which comprises adipocytes, pre-adipocytes, macrophages, endothelial…”
Get full text

Self-organization of bacterial biofilms is facilitated by extracellular DNA by Gloag, Erin S., Turnbull, Lynne, Huang, Alan, Vallotton, Pascal, Wang, Huabin, Nolan, Laura M., Mililli, Lisa, Hunt, Cameron, Lu, Jing, Osvath, Sarah R., Monahan, Leigh G., Cavaliere, Rosalia, Charles, Ian G., Wand, Matt P., Gee, Michelle L., Prabhakar, Ranganathan, Whitchurch, Cynthia B.

“…Twitching motility-mediated biofilm expansion is a complex, multicellular behavior that enables the active colonization of surfaces by many species of…”
Get full text

Viscosupplementation for the treatment of osteoarthritis of the knee by Bellamy, N, Campbell, J, Robinson, V, Gee, T, Bourne, R, Wells, G

“…Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. To assess the effects of…”
Get more information

Structures of two novel crystal forms of Aspergillus oryzae alpha amylase (taka-amylase) by Gee, Christine L., Holton, James M., McPherson, Alexander

“…The structures of Aspergillus oryzae α-amylase were determined in a tetragonal crystal, having one molecule as asymmetric unit, and a monoclinic crystal with…”
Get full text

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties by Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S

“…Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling…”
Get more information

antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping by Heras, Begoña, Totsika, Makrina, Peters, Kate M, Paxman, Jason J, Gee, Christine L, Jarrott, Russell J, Perugini, Matthew A, Whitten, Andrew E, Schembri, Mark A

“…Aggregation and biofilm formation are critical mechanisms for bacterial resistance to host immune factors and antibiotics. Autotransporter (AT) proteins, which…”
Get full text

Deconstruction of the Ras switching cycle through saturation mutagenesis by Bandaru, Pradeep, Shah, Neel H, Bhattacharyya, Moitrayee, Barton, John P, Kondo, Yasushi, Cofsky, Joshua C, Gee, Christine L, Chakraborty, Arup K, Kortemme, Tanja, Ranganathan, Rama, Kuriyan, John

“…Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high…”
Get full text

Sense of Coherence and Stress-Related Resilience: Investigating the Mediating and Moderating Mechanisms in the Development of Resilience Following Stress or Adversity by Mc Gee, Shauna L, Höltge, Jan, Maercker, Andreas, Thoma, Myriam V

“…Trauma, stress, and adversity are well-known for having lasting negative effects on health. Yet, not all individuals go on to develop psychopathology or…”
Get full text

Crystal structure of an RNA/DNA strand exchange junction by Cofsky, Joshua C, Knott, Gavin J, Gee, Christine L, Doudna, Jennifer A

“…Short segments of RNA displace one strand of a DNA duplex during diverse processes including transcription and CRISPR-mediated immunity and genome editing…”
Get full text

Phase and amplitude gradient method for the estimation of acoustic vector quantities by Thomas, Derek C, Christensen, Benjamin Y, Gee, Kent L

“…An alternative pressure-sensor based method for estimating the acoustic intensity, the phase and amplitude gradient estimation (PAGE) method, is presented…”
Get full text

Hypertension Prevalence and Related Risk Factors Among Mexican American Adults Are Increasing: National Health and Nutrition Examination Survey 1999 to 2018 by Briggs Early, Kathaleen, Valencia, Sandra I, Stendell-Hollis, Nicole, Klyve, Dominic, Gee, David L

“…Acculturation affects hypertension prevalence among Hispanic people, but there have been no recent analyses specifically focused on Mexican American (MA)…”
Get full text

Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC by Mavrici, Daniela, Marakalala, Mohlopheni J., Holton, James M., Prigozhin, Daniil M., Gee, Christine L., Zhang, Yanjia J., Rubin, Eric J., Alber, Tom

“…Bacterial growth and cell division are coordinated with hydrolysis of the peptidoglycan (PG) layer of the cell wall, but the mechanisms of regulation of…”
Get full text

A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria by Gee, Christine L, Papavinasasundaram, Kadamba G, Blair, Sloane R, Baer, Christina E, Falick, Arnold M, King, David S, Griffin, Jennifer E, Venghatakrishnan, Harene, Zukauskas, Andrew, Wei, Jun-Rong, Dhiman, Rakesh K, Crick, Dean C, Rubin, Eric J, Sassetti, Christopher M, Alber, Tom

“…Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms regulating this dynamic process remain obscure. Here, we…”
Get more information

Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants by Ball, B, Woroszchuk, E, Sukumaran, A, West, H, Afaq, A, Carruthers-Lay, D, Muselius, B, Gee, L, Langille, M, Pladwig, S, Kazi, S, Hendriks, A, Geddes-McAlister, J

“…Fungal infections impact over 25% of the global population. For the opportunistic fungal pathogen, Cryptococcus neoformans, infection leads to cryptococcosis…”
Get full text

Development and characterisation of whey protein micro-beads as potential matrices for probiotic protection by Doherty, S.B., Gee, V.L., Ross, R.P., Stanton, C., Fitzgerald, G.F., Brodkorb, A.

“…This study evaluated the efficacy of whey protein isolate (WPI) as an encapsulation matrix for the maintenance of Lactobacillus rhamnosus GG viability during…”
Get full text

Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria by Mularski, Anna, Wilksch, Jonathan J, Wang, Huabin, Hossain, Mohammed Akhter, Wade, John D, Separovic, Frances, Strugnell, Richard A, Gee, Michelle L

“…Increasing rates of antimicrobial-resistant medically important bacteria require the development of new, effective therapeutics, of which antimicrobial…”
Get full text

Variation in assembly stoichiometry in non‐metazoan homologs of the hub domain of Ca2+/calmodulin‐dependent protein kinase II by McSpadden, Ethan D., Xia, Zijie, Chi, Chris C., Susa, Anna C., Shah, Neel H., Gee, Christine L., Williams, Evan R., Kuriyan, John

“…The multi‐subunit Ca2+/calmodulin‐dependent protein kinase II (CaMKII) holoenzyme plays a critical role in animal learning and memory. The kinase domain of…”
Get full text