Search Results - "GEDULIN, BRONISLAVA"

Exenatide (Exendin-4) Improves Insulin Sensitivity and β-Cell Mass in Insulin-Resistant Obese fa/fa Zucker Rats Independent of Glycemia and Body Weight by Gedulin, Bronislava R, Nikoulina, Svetlana E, Smith, Pamela A, Gedulin, George, Nielsen, Loretta L, Baron, Alain D, Parkes, David G, Young, Andrew A

“…The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and β-cell mass were examined in nondiabetic,…”
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Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes by Calderon, Gerardo, McRae, Alison, Rievaj, Juraj, Davis, Judith, Zandvakili, Inuk, Linker-Nord, Sara, Burton, Duane, Roberts, Geoffrey, Reimann, Frank, Gedulin, Bronislava, Vella, Adrian, LaRusso, Nicholas F, Camilleri, Michael, Gribble, Fiona M, Acosta, Andres

“…The bile acid (BA) pathway plays a role in regulation of food intake and glucose metabolism, based mainly on findings in animal models. Our aim was to…”
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Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes by Chen, Lihong, Yao, Xiaozhou, Young, Andrew, McNulty, Judi, Anderson, Don, Liu, Yaping, Nystrom, Christopher, Croom, Dallas, Ross, Sean, Collins, Jon, Rajpal, Deepak, Hamlet, Kimberly, Smith, Chari, Gedulin, Bronislava

“…Bile acids are recognized as metabolic modulators. The present study was aimed at evaluating the effects of a potent Asbt inhibitor (264W94), which blocks…”
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Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial by Tiessen, Renger G, Kennedy, Ciara A, Keller, Bradley T, Levin, Nancy, Acevedo, Lisette, Gedulin, Bronislava, van Vliet, Andre A, Dorenbaum, Alejandro, Palmer, Melissa

“…Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical…”
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Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents by Tatarkiewicz, Krystyna, Smith, Pamela A, Sablan, Emmanuel J, Polizzi, Clara J, Aumann, Donald E, Villescaz, Christiane, Hargrove, Diane M, Gedulin, Bronislava R, Lu, Melissa G W, Adams, Lisa, Whisenant, Tina, Roy, Denis, Parkes, David G

“…The risk of developing pancreatitis is elevated in type 2 diabetes and obesity. Cases of pancreatitis have been reported in type 2 diabetes patients treated…”
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Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration by Gedulin, Bronislava R., Smith, Pamela A., Jodka, Carolyn M., Chen, Kim, Bhavsar, Sunil, Nielsen, Loretta L., Parkes, David G., Young, Andrew A.

“…Exenatide is a 39-amino acid peptide incretin mimetic approved for adjunctive treatment of type 2 diabetes. It shares several glucoregulatory activities with…”
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Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids by Trevaskis, James L, Mack, Christine M, Sun, Chengzao, Soares, Christopher J, D'Souza, Lawrence J, Levy, Odile E, Lewis, Diane Y, Jodka, Carolyn M, Tatarkiewicz, Krystyna, Gedulin, Bronislava, Gupta, Swati, Wittmer, Carrie, Hanley, Michael, Forood, Bruce, Parkes, David G, Ghosh, Soumitra S

“…Combination therapy is being increasingly used as a treatment paradigm for metabolic diseases such as diabetes and obesity. In the peptide therapeutics realm,…”
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Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187 by Gedulin, Bronislava R., Jodka, Carolyn M., Herrmann, Kathrin, Young, Andrew A.

“…Amylin is a 37-amino acid polypeptide co-secreted with insulin from the pancreatic β-cells. It complements insulin's stimulation of the rate of glucose…”
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Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta) by YOUNG, A. A, GEDULIN, B. R, BHAVSAR, S, BODKIN, N, JODKA, C, HANSEN, B, DENARO, M

“…Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus…”
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Biological activity of AC3174, a peptide analog of exendin-4 by Hargrove, Diane M., Kendall, Eric S., Reynolds, James M., Lwin, Aung N., Herich, John P., Smith, Pamela A., Gedulin, Bronislava R., Flanagan, Shawn D., Jodka, Carolyn M., Hoyt, Julie A., McCowen, Kevin M., Parkes, David G., Anderson, Christen M.

“…Exenatide, the active ingredient of BYETTA® (exenatide injection), is an incretin mimetic that has been developed for the treatment of patients with type 2…”
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Su1944 INTRARECTAL ADMINISTRATION OF CONJUGATED BILE ACIDS REDUCES FOOD INTAKE, REDUCES WEIGHT, AND INCREASES GLP-1 IN RODENTS AND EX VIVO HUMAN COLON by Ticho, Alexander L., Mcrae, Alison, Gedulin, Bronislava, Acosta, Andres

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Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats by GEDULIN, B. R, YOUNG, A. A

“…Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as…”
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Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats by Young, Andrew A., Jodka, Carolyn, Pittner, Richard, Parkes, David, Gedulin, Bronislava R.

“…The neuroendocrine hormone amylin, cosecreted with insulin from pancreatic β-cells in response to nutrient ingestion, has several physiologic actions to limit…”
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Effects of Ileo-Colonic Delivery of Conjugated Bile Acids on Glucose Metabolism, GLP-1, and Body Weight in Patients with Obesity and Type 2 Diabetes Mellitus—A Randomized Controlled Trial by MANRIQUE, GERARDO CALDERON, DAVIS, JUDITH, BONIS, ALISON N., KHEMANI, DISHA, GEDULIN, BRONISLAVA, VELLA, ADRIAN, CAMILLERI, MICHAEL, ACOSTA, ANDRES

“…Bile acid secretion increases significantly after Roux-in-Y gastric bypass and may play a role in weight loss after bariatric surgery. The acute…”
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446 – Modulation of Bile Acids Pathway in Obesity and Type 2 Diabetes by Calderon, Gerardo, Bonis, Alison N., Davis, Judith, Zandvakili, Inuk, Nord, Sara Linker, Burton, Duane, Vella, Adrian, LaRusso, Nicholas F., Gedulin, Bronislava, Camilleri, Michael, Acosta, Andres

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Amylin secretion from the perfused pancreas: dissociation from insulin and abnormal elevation in insulin-resistant diabetic rats by Gedulin, B, Cooper, G J, Young, A A

“…Amylin has been co-secreted from pancreatic islet beta-cells in constant proportion with insulin in some studies. We measured basal and glucose-stimulated…”
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PYY[3-36] administration decreases the respiratory quotient and reduces adiposity in diet-induced obese mice by Adams, Sean H, Lei, Chunli, Jodka, Carolyn M, Nikoulina, Svetlana E, Hoyt, Julie A, Gedulin, Bronislava, Mack, Christine M, Kendall, Eric S

“…In rodents, weight reduction after peptide YY[3-36] (PYY[3-36]) administration may be due largely to decreased food consumption. Effects on other processes…”
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Acute Experimental Pancreatitis in Rats Is Ameliorated by Treatment with Pramlintide, a Synthetic Analogue of the β-Cell Hormone Amylin: 189 by Gedulin, Bronislava, Smith, Pamela, Toschiaddi, Ginger, Polizzi, Clara, Young, Andrew

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Dose-response for glucagonostatic effect of amylin in rats by Gedulin, Bronislava R., Rink, Timothy J., Young, Andrew A.

“…Glucagon secretion from pancreatic α cells is inhibited by insulin from β cells. Amylin is a partner hormone to insulin cosecreted in response to nutrient…”
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Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight by Gedulin, Bronislava R, Nikoulina, Svetlana E, Smith, Pamela A, Gedulin, George, Nielsen, Loretta L, Baron, Alain D, Parkes, David G, Young, Andrew A

“…The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and beta-cell mass were examined in nondiabetic,…”
Get full text