Search Results - "GEDDES, JAMES W"

Ketone bodies mediate antiseizure effects through mitochondrial permeability transition by Kim, Do Young, Simeone, Kristina A., Simeone, Timothy A., Pandya, Jignesh D., Wilke, Julianne C., Ahn, Younghee, Geddes, James W., Sullivan, Patrick G., Rho, Jong M.

“…Objective Ketone bodies (KB) are products of fatty acid oxidation and serve as essential fuels during fasting or treatment with the high‐fat antiseizure…”
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Synaptic Mitochondria Are More Susceptible to Ca2+Overload than Nonsynaptic Mitochondria by Brown, Maile R., Sullivan, Patrick G., Geddes, James W.

“…Mitochondria in nerve terminals are subjected to extensive Ca2+fluxes and high energy demands, but the extent to which the synaptic mitochondria buffer Ca2+ is…”
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Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury by Yu, Chen Guang, Bondada, Vimala, Iqbal, Hina, Moore, Kate L, Gensel, John C, Bondada, Subbarao, Geddes, James W

“…Microglia/astrocyte and B cell neuroimmune responses are major contributors to the neurological deficits after traumatic spinal cord injury (SCI). Bruton…”
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High Cyclophilin D Content of Synaptic Mitochondria Results in Increased Vulnerability to Permeability Transition by Naga, Kranthi Kumari, Sullivan, Patrick G, Geddes, James W

“…Mitochondria isolated from synaptosomes are more sensitive to Ca2+ overload and the resultant opening of the mitochondrial permeability transition pore (mPTP)…”
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Incipient Alzheimer's Disease: Microarray Correlation Analyses Reveal Major Transcriptional and Tumor Suppressor Responses by Blalock, Eric M., Geddes, James W., Chen, Kuey Chu, Porter, Nada M., Markesbery, William R., Landfield, Philip W.

“…The pathogenesis of incipient Alzheimer's disease (AD) has been resistant to analysis because of the complexity of AD and the overlap of its early-stage…”
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Phage display for identification of serum biomarkers of traumatic brain injury by Ghoshal, Sarbani, Bondada, Vimala, Saatman, Kathryn E., Guttmann, Rodney P., Geddes, James W.

“…•Phage display is an unbiased approach to identify serum biomarkers.•Applicable to acute CNS injuries as well as neurological disorders.•Identification of GFAP…”
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Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses by Schaefer, Kellie A, Toral, Marcus A, Velez, Gabriel, Cox, Allison J, Baker, Sheila A, Borcherding, Nicholas C, Colgan, Diana F, Bondada, Vimala, Mashburn, Charles B, Yu, Chen-Guang, Geddes, James W, Tsang, Stephen H, Bassuk, Alexander G, Mahajan, Vinit B

“…We characterize calpain-5 (CAPN5) expression in retinal and neuronal subcellular compartments. CAPN5 gene variants were classified using the exome variant…”
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N Terminus of Calpain 1 Is a Mitochondrial Targeting Sequence by Badugu, RamaKrishna, Garcia, Matthew, Bondada, Vimala, Joshi, Aashish, Geddes, James W.

“…The ubiquitous m- and μ-calpains are thought to be localized in the cytosolic compartment, as is their endogenous inhibitor calpastatin. Previously, μ-calpain…”
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Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ‐1945 in a mouse traumatic brain injury model by Bains, Mona, Cebak, John E., Gilmer, Lesley K., Barnes, Colleen C., Thompson, Stephanie N., Geddes, James W., Hall, Edward D.

“…The efficacy of the amphipathic ketoamide calpain inhibitor SNJ‐1945 in attenuating calpain‐mediated degradation of the neuronal cytoskeletal protein…”
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Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology by Readnower, Ryan D, Hubbard, William Brad, Kalimon, Olivia J, Geddes, James W, Sullivan, Patrick G

“…Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade…”
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Dietary Supplementation with Organoselenium Accelerates Recovery of Bladder Expression, but Does Not Improve Locomotor Function, following Spinal Cord Injury by Meyer, Carolyn A, Singh, Ranjana, Jones, Mackenzie T, Yu, Chen-Guang, Power, Ronan F, Geddes, James W

“…Selenium is an essential element required for activity of several antioxidant enzymes, including glutathione peroxidase. Because of the critical role of the…”
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Calpain 1 and Calpastatin expression is developmentally regulated in rat brain by Li, Yanzhang, Bondada, Vimala, Joshi, Aashish, Geddes, James W.

“…Calpains and caspases are cysteine endopeptidases which share many similar substrates. Caspases are essential for caspase-dependent apoptotic death where…”
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Current status of fluid biomarkers in mild traumatic brain injury by Kulbe, Jacqueline R., Geddes, James W.

“…Mild traumatic brain injury (mTBI) affects millions of people annually and is difficult to diagnose. Mild injury is insensitive to conventional imaging…”
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Involvement of ERK2 in traumatic spinal cord injury by Yu, Chen-Guang, Yezierski, Robert P, Joshi, Aashish, Raza, Kashif, Li, Yanzhang, Geddes, James W

“…J. Neurochem. (2010) 10.1111/j.1471-4159.2010.06579.x Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the…”
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Mechanisms of Cell Death Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Acute Excitotoxic Necrosis and Delayed Apoptosis by Pang, Zhen, Geddes, James W

“…Impaired energy metabolism may play an important role in neuronal cell death after brain ischemia and in late-onset neurodegenerative diseases. Both…”
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N-Methyl-d-aspartate Receptor Antagonists Have Variable Affect in 3-Nitropropionic Acid Toxicity by Nasr, Payman, Carbery, Timothy, Geddes, James W.

“…There is accumulating evidence that excitotoxicity and oxidative stress resulting from excessive activation of glutamate ( N -methyl- d -aspartate) NMDA…”
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WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering by Avery, Michelle A., Rooney, Timothy M., Pandya, Jignesh D., Wishart, Thomas M., Gillingwater, Thomas H., Geddes, James W., Sullivan, Patrick G., Freeman, Marc R.

“…WldS (slow Wallerian degeneration) is a remarkable protein that can suppress Wallerian degeneration of axons and synapses [1], but how it exerts this effect…”
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Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy by Geddes, James W, Bondada, Vimala, Croall, Dorothy E, Rodgers, David W, Gal, Jozsef

“…Neovascular inflammatory vitreoretinopathy (NIV) is a rare eye disease that ultimately leads to complete blindness and is caused by mutations in the gene…”
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Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease by Blalock, Eric M., Buechel, Heather M., Popovic, Jelena, Geddes, James W., Landfield, Philip W.

“…► Subjects ( N = 30) spanned control, incipient, moderate and severe Alzheimer's disease. ► Focused on microarray analyses of laser-dissected hippocampal gray…”
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Calpain 5 Is Highly Expressed in the Central Nervous System (CNS), Carries Dual Nuclear Localization Signals, and Is Associated with Nuclear Promyelocytic Leukemia Protein Bodies by Singh, Ranjana, Brewer, M.Kathryn, Mashburn, Charles B., Lou, Dingyuan, Bondada, Vimala, Graham, Brantley, Geddes, James W.

“…Calpain 5 (CAPN5) is a non-classical member of the calpain family. It lacks the EF hand motif characteristic of classical calpains but retains catalytic and…”
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