Search Results - "GEBOERS, Sophie"

Gastrointestinal behavior of itraconazole in humans – Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution by Brouwers, Joachim, Geboers, Sophie, Mols, Raf, Tack, Jan, Augustijns, Patrick

“…[Display omitted] This study evaluated the fasted state gastrointestinal behavior of the lipophilic drug itraconazole, orally administered to healthy…”
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Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies by Stappaerts, Jef, Geboers, Sophie, Snoeys, Jan, Brouwers, Joachim, Tack, Jan, Annaert, Pieter, Augustijns, Patrick

“…[Display omitted] •Abiraterone acetate is unstable in human intestinal fluids of the fasted state.•Hydrolysis of abiraterone acetate results in intestinal…”
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Characterization of Peptide Chain Length and Constituency Requirements for YejABEF-Mediated Uptake of Microcin C Analogues by VONDENHOFF, Gaston H. M, BLANCHAERT, Bart, GEBOERS, Sophie, KAZAKOV, Teymur, DATSENKO, Kirill A, WANNER, Barry L, ROZENSKI, Jef, SEVERINOV, Konstantin, AERSCHOT, Arthur Van

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeting ESR1 mutation–induced transcriptional addiction in breast cancer with BET inhibition by Udden, Sm N., Wang, Qian, Kumar, Sunil, Malladi, Venkat S., Wu, Shwu-Yuan, Wei, Shuguang, Posner, Bruce A., Geboers, Sophie, Williams, Noelle S., Liu, Yulun, Sharma, Jayesh K., Mani, Ram S., Malladi, Srinivas, Parra, Karla, Hofstad, Mia, Raj, Ganesh V., Larios, Jose M., Jagsi, Reshma, Wicha, Max S., Park, Ben Ho, Gupta, Gaorav P., Chinnaiyan, Arul M., Chiang, Cheng-Ming, Alluri, Prasanna G.

“…Acquired mutations in the ligand-binding domain (LBD) of the gene encoding estrogen receptor α (ESR1) are common mechanisms of endocrine therapy resistance in…”
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In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin by Geboers, Sophie, Stappaerts, Jef, Tack, Jan, Annaert, Pieter, Augustijns, Patrick

“…[Display omitted] Simvastatin (SV) is marketed as a lactone ester prodrug which is hydrolyzed to the active simvastatin hydroxyacid (SVA). SV is characterized…”
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The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man by Geboers, Sophie, Stappaerts, Jef, Mols, Raf, Snoeys, Jan, Tack, Jan, Annaert, Pieter, Augustijns, Patrick

“…To relate the reported positive effect of food on the oral bioavailability of abiraterone to the intraluminal behavior of abiraterone acetate, an in vivo…”
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A male-derived nonribosomal peptide pheromone controls female schistosome development by Chen, Rui, Wang, Jipeng, Gradinaru, Irina, Vu, Hieu S., Geboers, Sophie, Naidoo, Jacinth, Ready, Joseph M., Williams, Noelle S., DeBerardinis, Ralph J., Ross, Elliott M., Collins, James J.

“…Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host…”
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A male-derived non-ribosomal peptide pheromone controls female schistosome development by Chen, Rui, Wang, Jipeng, Gradinaru, Irina, Vu, Hieu S., Geboers, Sophie, Naidoo, Jacinth, Ready, Joseph M., Williams, Noelle S., DeBerardinis, Ralph J., Ross, Elliott M., Collins, James J.

“…Schistosomes cause morbidity and death throughout the developing world due to the massive numbers of eggs female worms deposit into the blood of their host…”
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Intestinal behavior of the ester prodrug tenofovir DF in humans by Geboers, Sophie, Haenen, Steven, Mols, Raf, Brouwers, Joachim, Tack, Jan, Annaert, Pieter, Augustijns, Patrick

“…[Display omitted] Tenofovir-disoproxil-fumarate (TDF) is a double ester prodrug which enables intestinal uptake of tenofovir (TFV) after oral administration in…”
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Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase by Williams, Noelle S, Gonzales, Stephen, Naidoo, Jacinth, Rivera-Cancel, Giomar, Voruganti, Sukesh, Mallipeddi, Prema, Theodoropoulos, Panayotis C, Geboers, Sophie, Chen, Hong, Ortiz, Francisco, Posner, Bruce, Nijhawan, Deepak, Ready, Joseph M

“…A series of N-acyl benzothiazoles shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11. A prodrug form is…”
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Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration by Hu, Bin, Toda, Kosuke, Wang, Xiaoyu, Antczak, Monika I., Smith, Julianne, Geboers, Sophie, Nishikawa, Gen, Li, Hongyun, Dawson, Dawn, Fink, Stephen, Desai, Amar B., Williams, Noelle S., Markowitz, Sanford D., Ready, Joseph M.

“…15-Prostaglandin dehydrogenase (15-PGDH) regulates the concentration of prostaglandin E2 in vivo. Inhibitors of 15-PGDH elevate PGE2 levels and promote tissue…”
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Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts by Butler, Erin, Schwettmann, Blake, Geboers, Sophie, Hao, Guiyang, Kim, Jiwoong, Nham, Kien, Sun, Xiankai, Laetsch, Theodore W., Xu, Lin, Williams, Noelle S., Skapek, Stephen X.

“…Background Malignant peripheral nerve sheath tumor (MPNST) is an aggressive form of soft‐tissue sarcoma (STS) in children. Despite intensive therapy,…”
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