Search Results - "GEBHARD, F"
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The structural basis of agonist-induced activation in constitutively active rhodopsin
Published in Nature (London) (31-03-2011)“…Rhodopsin activation Structural studies of active states of the visual pigment rhodopsin, a G protein-coupled receptor, have previously been limited to…”
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2
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Published in Nature communications (13-09-2018)“…Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular…”
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3
Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
Published in Nature (London) (25-08-2016)“…A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors. Structural…”
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4
Dynamics and mechanism of a light-driven chloride pump
Published in Science (American Association for the Advancement of Science) (25-02-2022)“…Chloride transport by microbial rhodopsins is an essential process for which molecular details such as the mechanisms that convert light energy to drive ion…”
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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
Published in Nature communications (19-03-2019)“…Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind…”
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6
Structure of the µ-opioid receptor–Gi protein complex
Published in Nature (London) (28-06-2018)“…The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive…”
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7
Molecular signatures of G-protein-coupled receptors
Published in Nature (London) (14-02-2013)“…A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts…”
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8
Active state structures of a bistable visual opsin bound to G proteins
Published in Nature communications (16-10-2024)“…Opsins are G protein-coupled receptors (GPCRs) that have evolved to detect light stimuli and initiate intracellular signaling cascades. Their role as signal…”
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9
Femtosecond-to-millisecond structural changes in a light-driven sodium pump
Published in Nature (London) (09-07-2020)“…Light-driven sodium pumps actively transport small cations across cellular membranes 1 . These pumps are used by microorganisms to convert light into membrane…”
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10
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
Published in Nature (London) (29-04-2010)“…Rhodopsin is a prototypical heptahelical family A G-protein-coupled receptor (GPCR) responsible for dim-light vision. Light isomerizes rhodopsin's retinal…”
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11
The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
Published in Nature (London) (13-01-2011)“…β-adrenergic receptor structures Two papers by Brian Kobilka and colleagues describe the X-ray crystal structure of the human β 2 adrenergic receptor (β 2 AR)…”
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12
Dynamic properties of the one-dimensional Bose-Hubbard model
Published in Europhysics letters (01-02-2011)“…We use the density-matrix renormalization group method to investigate ground-state and dynamic properties of the one-dimensional Bose-Hubbard model, the…”
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13
Structure of a β1-adrenergic G-protein-coupled receptor
Published in Nature (London) (24-07-2008)“…G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 Å…”
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14
Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR
Published in Proceedings of the National Academy of Sciences - PNAS (16-07-2019)“…Light-sensitive G protein-coupled receptors (GPCRs)—rhodopsins—absorb photons to isomerize their covalently bound retinal, triggering conformational changes…”
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15
Correction of rhodopsin serial crystallography diffraction intensities for a lattice‐translocation defect
Published in Acta crystallographica. Section D, Biological crystallography. (01-03-2023)“…Rhodopsin is a G‐protein‐coupled receptor that detects light and initiates the intracellular signalling cascades that underpin vertebrate vision. Light…”
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C‑Graphs Tool with Graphical User Interface to Dissect Conserved Hydrogen-Bond Networks: Applications to Visual Rhodopsins
Published in Journal of chemical information and modeling (22-11-2021)“…Dynamic hydrogen-bond networks provide proteins with structural plasticity required to translate signals such as ligand binding into a cellular response or to…”
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17
A set of common movements within GPCR-G-protein complexes from variability analysis of cryo-EM datasets
Published in Journal of structural biology (01-06-2021)“…[Display omitted] •This analysis sheds light on the dynamical nature of GPCR-G-protein complexes.•The receptor' C-terminal tail and the alpha-helical domain of…”
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The 2.1 Å resolution structure of cyanopindolol-bound β1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor
Published in PloS one (24-03-2014)“…The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined…”
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Engineering G protein-coupled receptors to facilitate their structure determination
Published in Current opinion in structural biology (01-08-2009)“…Over the last two years, 10 new high-resolution structures of G protein-coupled receptors (GPCRs), either with antagonist bound or in an active-like state,…”
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The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods
Published in Nature structural & molecular biology (01-01-2022)“…In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed of three CNGA and one CNGB subunits, and it closes in response to…”
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