Search Results - "GEBHARD, F"

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  1. 1

    The structural basis of agonist-induced activation in constitutively active rhodopsin by Standfuss, Jörg, Edwards, Patricia C., D’Antona, Aaron, Fransen, Maikel, Xie, Guifu, Oprian, Daniel D., Schertler, Gebhard F. X.

    Published in Nature (London) (31-03-2011)
    “…Rhodopsin activation Structural studies of active states of the visual pigment rhodopsin, a G protein-coupled receptor, have previously been limited to…”
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  2. 2

    Development of an antibody fragment that stabilizes GPCR/G-protein complexes by Maeda, Shoji, Koehl, Antoine, Matile, Hugues, Hu, Hongli, Hilger, Daniel, Schertler, Gebhard F. X., Manglik, Aashish, Skiniotis, Georgios, Dawson, Roger J. P., Kobilka, Brian K.

    Published in Nature communications (13-09-2018)
    “…Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular…”
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  3. 3

    Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region by Venkatakrishnan, A. J., Deupi, Xavier, Lebon, Guillaume, Heydenreich, Franziska M., Flock, Tilman, Miljus, Tamara, Balaji, Santhanam, Bouvier, Michel, Veprintsev, Dmitry B., Tate, Christopher G., Schertler, Gebhard F. X., Babu, M. Madan

    Published in Nature (London) (25-08-2016)
    “…A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors. Structural…”
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    Structure of the µ-opioid receptor–Gi protein complex by Koehl, Antoine, Hu, Hongli, Maeda, Shoji, Zhang, Yan, Qu, Qianhui, Paggi, Joseph M., Latorraca, Naomi R., Hilger, Daniel, Dawson, Roger, Matile, Hugues, Schertler, Gebhard F. X., Granier, Sebastien, Weis, William I., Dror, Ron O., Manglik, Aashish, Skiniotis, Georgios, Kobilka, Brian K.

    Published in Nature (London) (28-06-2018)
    “…The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive…”
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  7. 7

    Molecular signatures of G-protein-coupled receptors by Venkatakrishnan, A. J., Deupi, Xavier, Lebon, Guillaume, Tate, Christopher G., Schertler, Gebhard F., Babu, M. Madan

    Published in Nature (London) (14-02-2013)
    “…A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts…”
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  8. 8

    Active state structures of a bistable visual opsin bound to G proteins by Tejero, Oliver, Pamula, Filip, Koyanagi, Mitsumasa, Nagata, Takashi, Afanasyev, Pavel, Das, Ishita, Deupi, Xavier, Sheves, Mordechai, Terakita, Akihisa, Schertler, Gebhard F. X., Rodrigues, Matthew J., Tsai, Ching-Ju

    Published in Nature communications (16-10-2024)
    “…Opsins are G protein-coupled receptors (GPCRs) that have evolved to detect light stimuli and initiate intracellular signaling cascades. Their role as signal…”
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    Tracking G-protein-coupled receptor activation using genetically encoded infrared probes by Sakmar, Thomas P, Deupi, Xavier, Vogel, Reiner, Ye, Shixin, Zaitseva, Ekaterina, Caltabiano, Gianluigi, Schertler, Gebhard F. X

    Published in Nature (London) (29-04-2010)
    “…Rhodopsin is a prototypical heptahelical family A G-protein-coupled receptor (GPCR) responsible for dim-light vision. Light isomerizes rhodopsin's retinal…”
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  11. 11

    The structural basis for agonist and partial agonist action on a β1-adrenergic receptor by Warne, Tony, Moukhametzianov, Rouslan, Baker, Jillian G., Nehmé, Rony, Edwards, Patricia C., Leslie, Andrew G. W., Schertler, Gebhard F. X., Tate, Christopher G.

    Published in Nature (London) (13-01-2011)
    “…β-adrenergic receptor structures Two papers by Brian Kobilka and colleagues describe the X-ray crystal structure of the human β 2 adrenergic receptor (β 2 AR)…”
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  12. 12

    Dynamic properties of the one-dimensional Bose-Hubbard model by Ejima, S, Fehske, H, Gebhard, F

    Published in Europhysics letters (01-02-2011)
    “…We use the density-matrix renormalization group method to investigate ground-state and dynamic properties of the one-dimensional Bose-Hubbard model, the…”
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  13. 13

    Structure of a β1-adrenergic G-protein-coupled receptor by Warne, Tony, Serrano-Vega, Maria J., Baker, Jillian G., Moukhametzianov, Rouslan, Edwards, Patricia C., Henderson, Richard, Leslie, Andrew G. W., Tate, Christopher G., Schertler, Gebhard F. X.

    Published in Nature (London) (24-07-2008)
    “…G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 Å…”
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  14. 14

    Crystal structure of jumping spider rhodopsin-1 as a light sensitive GPCR by Varma, Niranjan, Mutt, Eshita, Mühle, Jonas, Panneels, Valérie, Terakita, Akihisa, Deupi, Xavier, Nogly, Przemyslaw, Schertler, Gebhard F. X., Lesca, Elena

    “…Light-sensitive G protein-coupled receptors (GPCRs)—rhodopsins—absorb photons to isomerize their covalently bound retinal, triggering conformational changes…”
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  15. 15

    Correction of rhodopsin serial crystallography diffraction intensities for a lattice‐translocation defect by Rodrigues, Matthew J., Casadei, Cecilia M., Weinert, Tobias, Panneels, Valerie, Schertler, Gebhard F. X.

    “…Rhodopsin is a G‐protein‐coupled receptor that detects light and initiates the intracellular signalling cascades that underpin vertebrate vision. Light…”
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  16. 16

    C‑Graphs Tool with Graphical User Interface to Dissect Conserved Hydrogen-Bond Networks: Applications to Visual Rhodopsins by Bertalan, Éva, Lesca, Elena, Schertler, Gebhard F. X, Bondar, Ana-Nicoleta

    “…Dynamic hydrogen-bond networks provide proteins with structural plasticity required to translate signals such as ligand binding into a cellular response or to…”
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  17. 17

    A set of common movements within GPCR-G-protein complexes from variability analysis of cryo-EM datasets by Marino, Jacopo, Schertler, Gebhard F.X.

    Published in Journal of structural biology (01-06-2021)
    “…[Display omitted] •This analysis sheds light on the dynamical nature of GPCR-G-protein complexes.•The receptor' C-terminal tail and the alpha-helical domain of…”
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  18. 18

    The 2.1 Å resolution structure of cyanopindolol-bound β1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor by Miller-Gallacher, Jennifer L, Nehmé, Rony, Warne, Tony, Edwards, Patricia C, Schertler, Gebhard F X, Leslie, Andrew G W, Tate, Christopher G

    Published in PloS one (24-03-2014)
    “…The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline. We have determined…”
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  19. 19

    Engineering G protein-coupled receptors to facilitate their structure determination by Tate, Christopher G, Schertler, Gebhard FX

    Published in Current opinion in structural biology (01-08-2009)
    “…Over the last two years, 10 new high-resolution structures of G protein-coupled receptors (GPCRs), either with antagonist bound or in an active-like state,…”
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  20. 20

    The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods by Barret, Diane C. A., Schertler, Gebhard F. X., Kaupp, U. Benjamin, Marino, Jacopo

    Published in Nature structural & molecular biology (01-01-2022)
    “…In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed of three CNGA and one CNGB subunits, and it closes in response to…”
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