Search Results - "GEAR, ADRIAN R.L."

P-Selectin–Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease by Polanowska-Grabowska, Renata, Wallace, Kori, Field, Joshua J, Chen, Lanlin, Marshall, Melissa A, Figler, Robert, Gear, Adrian R.L, Linden, Joel

“…OBJECTIVE—To determine the role of platelets in stimulating mouse and human neutrophil activation and pulmonary injury in sickle cell disease (SCD). METHODS…”
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Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host Defense by GEAR, ADRIAN R.L., CAMERINI, DAVID

“…ABSTRACT Blood platelets play critical roles in hemostasis, providing rapid essential protection against bleeding and catalyzing the important slower formation…”
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Heat-shock protein 90 complexes in resting and thrombin-activated platelets by Suttitanamongkol, Sudawadee, Polanowska-Grabowska, Renata, Gear, Adrian R.L

“…Heat-shock protein 90 (hsp90) is a chaperone important for the function of many signaling proteins. In this study, we show that hsp90 exists in resting…”
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Platelet Adhesion to Collagen and Collagen-Related Peptide Under Flow: Roles of the α2β1 Integrin, GPVI, and Src Tyrosine Kinases by Polanowska-Grabowska, Renata, Gibbins, Jonathan M, Gear, Adrian R.L

“…OBJECTIVE—Platelet stimulation by collagen and collagen-related peptides (CRPs) is associated with activation of protein tyrosine kinases. In the present…”
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Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation by Suttitanamongkol, S, Gear, A R, Polanowska-Grabowska, R

“…Geldanamycin (GA), a benzoquinoid ansamycin antibiotic, has been used as a tyrosine kinase inhibitor and an anti-tumour agent and is known to bind to…”
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Sphingomyelinase Activity in Human Platelets by Simon, Carl G, Chatterjee, Subroto, Gear, Adrian R.L

“…The sphingolipid metabolites, ceramide, sphingosine, and sphingosine-1-phosphate, may be involved in several signalling pathways and may regulate cell…”
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Human Platelet Aggregation Is Not Altered by Shiga Toxins 1 or 2 by Viisoreanu, Delia, Polanowska-Grabowska, Renata, Suttitanamongkol, Sudawadee, Obrig, Tom G, Gear, Adrian R.L

“…The hemolytic uremic syndrome involves the presence of Shiga toxin producing strains of Escherichia coli and is associated with thrombocytopenia, platelet…”
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Protein kinase A mediates inhibition of the thrombin-induced platelet shape change by nitric oxide by Jensen, Baard Olav, Selheim, Frode, Døskeland, Stein Ove, Gear, Adrian R.L., Holmsen, Holm

“…The thrombin-induced platelet shape change was blocked by nitric oxide (NO), as revealed by scanning electron microscopy, light transmission, and…”
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Shiga Toxin 2 and Lipopolysaccharide Induce Human Microvascular Endothelial Cells To Release Chemokines and Factors That Stimulate Platelet Function by Guessous, Fadila, Marcinkiewicz, Marek, Polanowska-Grabowska, Renata, Kongkhum, Sudawadee, Heatherly, Daniel, Obrig, Tom, Gear, Adrian R L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Platelet Chemokines and Chemokine Receptors: Linking Hemostasis, Inflammation, and Host Defense by GEAR, ADRIAN R.L., CAMERINI, DAVID

“…Blood platelets play critical roles in hemostasis, providing rapid essential protection against bleeding and catalyzing the important slower formation of…”
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Platelet Adhesion to Collagen and Collagen-Related Peptide Under Flow: Roles of the α 2 β 1 Integrin, GPVI, and Src Tyrosine Kinases by Polanowska-Grabowska, Renata, Gibbins, Jonathan M., Gear, Adrian R.L.

“…Objective— Platelet stimulation by collagen and collagen-related peptides (CRPs) is associated with activation of protein tyrosine kinases. In the present…”
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LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22) by Coleman, Leon G., Polanowska-Grabowska, Renata K., Marcinkiewicz, Marek, Gear, AdrianR.L.

“…The in vitro oxidation of low-density lipoprotein (LDL) by hypochlorous acid produces a modified form (HOCl-LDL) capable of stimulating platelet function. We…”
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Platelet adhesion assays under flow using matrix protein-coupled adhesion columns by Polanowska-Grabowska, Renata, Gear, Adrian R L

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Exchange of C16-Ceramide between Phospholipid Vesicles by Simon, Carl G, Holloway, Peter W, Gear, Adrian R. L

“…Ceramide is considered to be an important signaling molecule in cellular processes such as cell growth, secretion, differentiation, and apoptosis. This implies…”
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Membrane-Destabilizing Properties of C2-Ceramide May Be Responsible for Its Ability To Inhibit Platelet Aggregation by Simon, Carl G, Gear, Adrian R. L

“…We have studied the effects of short-chain ceramides on platelet structure and function. N-Acetylsphingosine (C2-ceramide), a cell-permeable short-chain…”
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Platelet adhesion to collagen and collagen-related peptide under flow: roles of the [alpha]2[beta]1 integrin, GPVI, and Src tyrosine kinases by Polanowska-Grabowska, Renata, Gibbins, Jonathan M, Gear, Adrian R L

“…Platelet stimulation by collagen and collagen-related peptides (CRPs) is associated with activation of protein tyrosine kinases. In the present study, we…”
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Local Anesthetic Actions on Thromboxane-Induced Platelet Aggregation by Lo, Bernard, Hönemann, Christian W., Kohrs, Rainer, Hollmann, Markus W., Polanowska-Grabowska, Renate K., Gear, Adrian R. L., Durieux, Marcel E.

“…Some local anesthetics (LA), in concentrations present in blood during IV or epidural infusion, inhibit thrombus formation in the postoperative period. Studies…”
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Platelet Adhesion to Collagen Under Flow Causes Dissociation of a Phosphoprotein Complex of Heat-Shock Proteins and Protein Phosphatase 1 by Polanowska-Grabowska, Renata, Simon, Carl G., Falchetto, Rocco, Shabanowitz, Jeffrey, Hunt, Donald F., Gear, Adrian R.L.

“…Phosphorylation/dephosphorylation events in human blood platelets were investigated during their adhesion to collagen under flow conditions. Using 32P-labeled…”
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Activation of Protein Kinase C Is Required for the Stable Attachment of Adherent Platelets to Collagen but Is Not Needed for the Initial Rapid Adhesion Under Flow Conditions by Polanowska-Grabowska, Renata, Gear, Adrian R. L

“…We have investigated the role of protein kinase C (PKC) in the initial events of α2β1-integrin–mediated platelet adhesion to collagen under flow conditions…”
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Role of cyclic nucleotides in rapid platelet adhesion to collagen by Polanowska-Grabowska, R, Gear, AR

“…Adhesion of human platelets to type I collagen under arterial flow conditions is extremely fast, being mediated primarily by the alpha 2 beta 1 integrin…”
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