Search Results - "GAWLAK, S. L"

BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells by FRIEDMAN, P. N, MCANDREW, S. J, GAWLAK, S. L, CHACE, D, TRAIL, P. A, BROWN, J. P, SIEGALL, C. B

“…We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of Pseudomonas exotoxin. The chimeric…”
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Identification of a specific tyrosine residue in Bryodin 1 distinct from the active site but required for full catalytic and cytotoxic activity by Fryxell, Daniel K., Gawlak, Susan L., Dodge, Robert W., Siegall, Clay B.

“…Bryodin 1 (BD1) is a type I ribosome‐inactivating protein (RIP) with low inherent animal toxicity. It has been cloned recently and the recombinant protein…”
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Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; Comparison with acidic fibroblast growth factor-Pseudomonas exotoxin by Gawlak, Susan L, Pastan, Ira, Siegall, Clay B

“…We have constructed growth factor-toxin chimeric molecules composed of basic fibroblast growth factor (bFGF) and two different binding mutant forms of…”
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Lymphoid organ weights and organ: body weight ratios of growing beagles by Yang, T J, Gawlak, S L

“…Although dogs, especially beagles, are used extensively in biological and clinical investigations, the literature dealing with normal biological measurements…”
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Cytotoxicity of chimeric (human-murine) monoclonal antibody BR96 IgG, F(ab')2, and Fab' conjugated to Pseudomonas exotoxin by Siegall, Clay B, Gawlak, Susan L, Chin, Jeffrey J, Zoeckler, Mary E, Kadow, Kathleen F, Brown, Joseph P, Braslawsky, Gary R

“…We have made antigen-specific cytotoxic reagents by conjugating the chimeric antibody BR96 (chiBR96) to Pseudomonas exotoxin A (PE), as either native PE or a…”
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Antibody-forming cells in the contralateral and ipsilateral lymph nodes draining the locally immunized supramammary/suprainguinal region by Yang, T J, Gawlak, S L, Ports, W C, Daniels, W H

“…The Jerne hemolytic plaque assay was used to compare the number of antibody forming cells in the ipsilateral supramammary/suprainguinal lymph node which drains…”
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Expression and Characterization of Bryodin 1 and a Bryodin 1-Based Single-Chain Immunotoxin from Tobacco Cell Culture by Francisco, Joseph A, Gawlak, Susan L, Miller, Michael, Bathe, Jessie, Russell, David, Chace, Dana, Mixan, Bruce, Zhao, Lei, Fell, H. Perry, Siegall, Clay B

“…Bryodin 1 (BD1) is a potent ribosome-inactivating protein (RIP) isolated from the plant Bryonia dioica. It is relatively nontoxic in rodents (LD50 > 40 mg/kg)…”
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Construction, Expression, and Characterization of BD1-G28-5 sFv, a Single-chain Anti-CD40 Immunotoxin Containing the Ribosome-inactivating Protein Bryodin 1 by Francisco, Joseph A., Gawlak, Susan L., Siegall, Clay B.

“…The major limitation to the use of immunotoxins in the clinic is the toxicity associated with the toxin moiety. BD1-G28-5 single-chain Fv (sFv) is a…”
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Molecular, Biological, and Preliminary Structural Analysis of Recombinant Bryodin 1, a Ribosome-Inactivating Protein from the Plant Bryonia dioica by Gawlak, Susan L, Neubauer, Michael, Klei, Herbert E, Chang, Einspahr, Howard M, Siegall, Clay B

“…Bryonia dioica (Cucurbitaceae family) produces at least two type I ribosome-inactivating proteins, bryodin 1 (BD1) and bryodin 2 (BD2). A cDNA sequence…”
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Characterization of Ribosome-Inactivating Proteins Isolated from Bryonia dioica and Their Utility as Carcinoma-Reactive Immunoconjugates by Siegall, Clay B, Gawlak, Susan L, Chace, Dana, Wolff, Edith A, Mixan, Bruce, Marquardt, Hans

“…Two ribosome-inactivating proteins (RIPs) were isolated and characterized from the roots of Bryonia dioica. One of these was a novel 27-kDa protein termed…”
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In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins by Siegall, Clay B, Gawlak, Susan L, Chace, Dana F, Merwin, June R, Pastan, Ira

“…Fibroblast growth factor receptors are highly expressed in a variety of cancer cells and activated vasculature. Using chimeric toxins targeted to cell-surface…”
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Homodimeric forms of bombesin act as potent antagonists of bombesin on Swiss 3T3 cells by Gawlak, S L, Kiener, P A, Braslawsky, G R, Greenfield, R S

“…Two Lys3-bombesin dimers were prepared by crosslinking epsilon-amino groups Lys3-bombesin with noncleavable (glutaraldehyde) and cleavable…”
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