Comparison of the effects of immediate‐release omeprazole oral suspension, delayed‐release lansoprazole capsules and delayed‐release esomeprazole capsules on nocturnal gastric acidity after bedtime dosing in patients with night‐time GERD symptoms

Summary Background Gastro‐oesophageal reflux disease (GERD) patients on proton pump inhibitors before breakfast or dinner have acid recovery at night. Bedtime immediate‐release omeprazole (IR‐OME) demonstrated better control of nocturnal pH than pantoprazole before dinner. Aim To compare repeated on...

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Bibliographic Details
Published in:	Alimentary pharmacology & therapeutics Vol. 25; no. 2; pp. 197 - 205
Main Authors:	KATZ, P. O., KOCH, F. K., BALLARD, E. D., BAGIN, R. G., GAUTILLE, T. C., CHECANI, G. C., HOGAN, D. L., PRATHA, V. S. V.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 15-01-2007 Blackwell
Subjects:	2-Pyridinylmethylsulfinylbenzimidazoles - therapeutic use Administration, Oral Adult Aged Antacids - therapeutic use Anti-Ulcer Agents - therapeutic use Biological and medical sciences Cross-Over Studies Digestive system Drug Administration Schedule Esomeprazole Female Gastric Acid - secretion Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - drug therapy Humans Lansoprazole Male Medical sciences Middle Aged Omeprazole - therapeutic use Pharmacology. Drug treatments Treatment Outcome Night H Antiulcer agent K Posology Proton pump inhibitor Antisecretory agent Release Human Stomach Digestive system Enzyme Controlled release form Oral administration Enzyme inhibitor Suspension Acidity Capsule Omeprazole Symptomatology Benzimidazole derivatives Esomeprazole Dosage form exchanging ATPase Hydrolases Comparative study Lansoprazole
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Summary:	Summary Background Gastro‐oesophageal reflux disease (GERD) patients on proton pump inhibitors before breakfast or dinner have acid recovery at night. Bedtime immediate‐release omeprazole (IR‐OME) demonstrated better control of nocturnal pH than pantoprazole before dinner. Aim To compare repeated once daily bedtime dosing of IR‐OME, lansoprazole and esomeprazole on nocturnal gastric acidity. Methods Open‐label, randomized, crossover study enrolling 54 patients with nocturnal GERD symptoms comparing IR‐OME, lansoprazole and esomeprazole at steady state for nocturnal acid breakthrough (NAB), percentage of time with gastric pH > 4 and median gastric pH. Results Onset of nocturnal acid control with IR‐OME was rapid. During the first half of the night, percentage of time with gastric pH > 4 and median gastric pH were significantly higher after IR‐OME compared to esomeprazole or lansoprazole (P < 0.001, both comparisons). Over the 8‐h night‐time period, acid control with IR‐OME was significantly better than lansoprazole (P < 0.001), and comparable to esomeprazole. IR‐OME reduced NAB compared with esomeprazole and lansoprazole (61% vs. 92% and 92%; P < 0.001, both comparisons). Conclusions Bedtime IR‐OME provided more rapid control of night‐time gastric pH and decreased NAB compared with esomeprazole and lansoprazole. Nocturnal acid control with IR‐OME was superior to lansoprazole and comparable to esomeprazole. Bedtime dosing with IR‐OME may be effective for patients with night‐time heartburn.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0269-2813 1365-2036
DOI:	10.1111/j.1365-2036.2006.03191.x