Search Results - "GAUTHERON, P"

Organotypic models for the assessment/prediction of ocular irritation by Chamberlain, M, Gad, S.C, Gautheron, P, Prinsen, M.K

“…The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and…”
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Irag Working Group 1: Organotypic models for the assessment/prediction of ocular irritation by Chamberlain, M., Gad, S.C., Gautheron, P., Prinsen, M.K.

“…The brief of the Organotypic Models Working Group was to review data submitted to the Interagency Regulatory Alternatives Group on the use of isolated eyes and…”
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Topically active carbonic anhydrase inhibitors. 1. O-Acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide by Woltersdorf, O. W., Schwam, H., Bicking, J. B., Brown, S. L., DeSolms, S. J., Fishman, D. R., Graham, S. L., Gautheron, P. D., Hoffman, J. M.

“…A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a…”
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Some remarks concerning Nambu mechanics by Gautheron, Philippe

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On the pharmacology of L-645,151: a topically effective ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Schmitt, C, Viader, M P, Conquet, P, Smith, R L, Share, N N, Stone, C A

“…L-645,151 [(2-sulfamoyl-6-benzothiazolyl)-2,2-dimethylpropionate] is the O-pivaloyl ester of L-643,799 (6-hydroxybenzothiazole-2-sulfonamide), topically…”
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L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals by Sugrue, M.F., Gautheron, P., Mallorga, P., Nolan, T.E., Graham, S.L., Schwam, H., Shepard, K.L., Smith, R.L.

“…1 L‐662,583 was a potent inhibitor in vitro of purified, human erythrocyte carbonic anhydrase II, possessing an IC50 of 0.7 nm. The IC50 values for MK‐927,…”
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A study of PAF-induced ocular inflammation in the rat and its inhibition by the PAF antagonist, L-652,731 by Gautheron, P D, Coulbault, L, Sugrue, M F

“…A significant inflammatory reaction in the rat conjunctiva followed the subconjunctival injection of synthetic platelet activating factor (PAF) in doses which…”
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Influence of dietary fats on atherosclerosis, coagulation and platelet phospholipids in rabbits by Renaud, S, Gautheron, P

“…Male rabbits were fed for six months diets comprising cholesterol (0.1%) and either butter alone (10%) or butter (5%) plus cacao butter, coconut oil, olive…”
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Simple Facts Concerning Nambu Algebras by Gautheron, Philippe

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The ability of salbutamol and theophylline to suppress immediate allergic conjunctivitis in the guinea pig by GAUTHERON, P, SUGRUE, M. F

“…Topically administered salbutamol was extremely effective in suppressing immediate allergic conjunctivitis in the guinea pig; a dose as low as 0.1% elicited…”
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Eleventh International Congress of Psychotechnics; problems in relations between psychiatrics and psychology in practice by GAUTHERON, P

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L-653,328: an ocular hypotensive agent with modest beta receptor blocking activity by Sugrue, MF, Gautheron, P, Grove, J, Mallorga, P, Viader, MP, Baldwin, JJ, Ponticello, GS, Varga, SL

“…L-653,328 is the acetate ester of L-652,698 ((S)-3-tert-butylamino-1-[4-[2(hydroxy)ethyl]phenoxy]2-propanol). The penetration of L-652,698 into the albino…”
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MK-927: a topically active ocular hypotensive carbonic anhydrase inhibitor by Sugrue, M F, Gautheron, P, Grove, J, Mallorga, P, Viader, M P, Schwam, H, Baldwin, J J, Christy, M E, Ponticello, G S

“…MK-927 (dl-5,6-dihydro-4-(2-methylpropylamino)-4H-thieno(2,3b)thiopyra n-2-sulfonamide-7,7-dioxide hydrochloride) is a water soluble, carbonic anhydrase…”
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Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits by LOTTI, V. J, SCHMITT, C. J, GAUTHERON, P. D

“…A single topical instillation (50 microliter) of the water soluble sodium salt of dichlorphenamide (10%) produced a pronounced and prolonged lowering of…”
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Clotting activity of platelet phospholipids in rat and man by Gautheron, P, Dumont, E, Renaud, S

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Assessment of cytotoxicity assays as predictors of ocular irritation of pharmaceuticals by Sina, J F, Ward, G J, Laszek, M A, Gautheron, P D

“…We have evaluated the use of cytotoxicity assays in vitro as an alternative to predicting ocular irritation potential in animals. Three different measures of…”
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Platelet factor 3 activity in washed platelets by Renaud, S, Gautheron, P, Rosenstein, H

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A study on the ocular and extraocular pharmacology of metipranolol by SUGRUE, M. F, ARMSTRONG, J. M, GAUTHERON, P, VIADER, M. P

“…Metipranolol (Betamann) is a clinically efficacious ocular hypotensive drug and preclinical experiments were undertaken to characterize this beta-adrenoceptor…”
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Platelet factor 3 activity and platelet aggregation in patients submitted to coronarography by Renaud, S, Gautheron, P, Arbogast, R, Dumont, E

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Platelet lipid composition by Douste-Blazy, L, Chap, H, Gautheron, P

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