Search Results - "GAULDIE, J"

TGF-beta, Smad3 and the process of progressive fibrosis by Gauldie, J, Bonniaud, P, Sime, P, Ask, K, Kolb, M

“…Transient adenovirus-mediated gene transfer of active TGF-beta1 (transforming growth factor-beta1) induces severe and progressive fibrosis in rodent lung…”
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Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin by Knippenberg, Sarah, Ueberberg, Bianca, Maus, Regina, Bohling, Jennifer, Ding, Nadine, Tort Tarres, Meritxell, Hoymann, Heinz-Gerd, Jonigk, Danny, Izykowski, Nicole, Paton, James C, Ogunniyi, Abiodun D, Lindig, Sandro, Bauer, Michael, Welte, Tobias, Seeger, Werner, Guenther, Andreas, Sisson, Thomas H, Gauldie, Jack, Kolb, Martin, Maus, Ulrich A

“…Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is characterised…”
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Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis by Kolb, Martin, Margetts, Peter J., Anthony, Daniel C., Pitossi, Fernando, Gauldie, Jack

“…IL-1β is one of a family of proinflammatory cytokines thought to be involved in many acute and chronic diseases. Although it is considered to participate in…”
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IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses by Xing, Z, Gauldie, J, Cox, G, Baumann, H, Jordana, M, Lei, X F, Achong, M K

“…IL-6 is induced often together with the proinflammatory cytokines TNFalpha and IL-1 in many alarm conditions, and circulating IL-6 plays an important role in…”
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Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection by Jeyanathan, M, Thanthrige-Don, N, Afkhami, S, Lai, R, Damjanovic, D, Zganiacz, A, Feng, X, Yao, X-D, Rosenthal, K L, Fe Medina, M, Gauldie, J, Ertl, H C, Xing, Z

“…Pulmonary tuberculosis (TB) remains to be a major global health problem despite many decades of parenteral use of Bacillus Calmette–Guérin (BCG) vaccine…”
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Overexpression of transforming growth factor-β1 in fetal monkey lung results in prenatal pulmonary fibrosis by TARANTAL, A. F, CHEN, H, SHI, T. T, LU, C.-H, FANG, A. B, BUCKLEY, S, KOLB, M, GAULDIE, J, WARBURTON, D, SHI, W

“…Altered transforming growth factor (TGF)-β expression levels have been linked to a variety of human respiratory diseases, including bronchopulmonary dysplasia…”
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TGF-β receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung by CHEN, H, ZHUANG, F, MOSES, H. L, SHI, W, LIU, Y.-H, XU, B, DEL MORAL, P, DENG, W, CHAI, Y, KOLB, M, GAULDIE, J, WARBURTON, D

“…Transforming growth factor (TGF)-beta signalling plays important roles in regulating lung development. However, the specific regulatory functions of TGF-beta…”
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Proinflammatory properties of IL-4 in the intestinal microenvironment by Van Kampen, C, Gauldie, J, Collins, S M

“…IL-4 is involved in type 2 T helper cell (Th)2-type immune responses and, in some cases, can promote Th1 responses. However, the proinflammatory potential of…”
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Three-dimensional computed tomography imaging in an animal model of emphysema by Froese, A. R, Ask, K, Labiris, R, Farncombe, T, Warburton, D, Inman, M. D, Gauldie, J, Kolb, M

“…Emphysema is a major health problem and novel drugs are needed. Animal disease models are pivotal in their development, but the validity and sensitivity of…”
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Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-β on the survival of axotomized retinal ganglion cells by Koeberle, P.D, Gauldie, J, Ball, A.K

“…Nitric oxide, synthesized by reactive microglia and astrocytes has been implicated in promoting neuronal degeneration observed in many diseases and insults of…”
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Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1 by Motomura, Y, Khan, W I, El-Sharkawy, R T, Verma-Gandhu, M, Verdu, E F, Gauldie, J, Collins, S M

“…Background and aims: Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to…”
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Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons by Murphy, P. G., Borthwick, L. A., Altares, M., Gauldie, J., Kaplan, D., Richardson, P. M.

“…In low‐density, serum‐free cultures of neurons from embryonic rat dorsal root ganglia, interleukin‐6 supports the survival of less than one third of the…”
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Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes by Sallenave, J M, Shulmann, J, Crossley, J, Jordana, M, Gauldie, J

“…The regulation of the activity of potentially harmful proteinases secreted by neutrophils during inflammation is important for the prevention of excessive…”
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Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice by Murphy, P. G., Ramer, M. S., Borthwick, L., Gauldie, J., Richardson, P. M., Bisby, M. A.

“…Partial nerve injury is a potential cause of distressing chronic pain for which conventional analgesic treatment with opiates or anti‐inflammatory agents is…”
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Interferon β 2/B-Cell Stimulatory Factor Type 2 Shares Identity with Monocyte-Derived Hepatocyte-Stimulating Factor and Regulates the Major Acute Phase Protein Response in Liver Cells by Gauldie, Jack, Richards, Carl, Harnish, Del, Lansdorp, Peter, Baumann, Heinz

“…One of the oldest and most preserved of the homeostatic responses of the body to injury is the acute phase protein response associated with inflammation. The…”
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Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection by Zhu, Q, Thomson, C W, Rosenthal, K L, McDermott, M R, Collins, S M, Gauldie, J

“…The large intestinal mucosa contains immunological structures that may potentially serve as a site for induction of mucosal immunity against infections…”
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Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models by Emtage, P C, Wan, Y, Hitt, M, Graham, F L, Muller, W J, Zlotnik, A, Gauldie, J

“…We have previously demonstrated that intratumoral injection with Ad vectors expressing IL-2 or IL-12 can induce regression in a murine breast cancer model…”
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Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions by Xing, Z, Ohkawara, Y, Jordana, M, Graham, F, Gauldie, J

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine whose expression is increased in numerous respiratory diseases,…”
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Adenoviral-mediated gene transfer into bone marrow: an effective surgical technique in rat by Rodriguez-Lecompte, J C, Romero-Perez, G A, Ramirez-Yañez, G, Ask, K, Gauldie, J

“…The role of transforming growth factor-beta 1 (TGF-β₁) in the onset of bone marrow fibrosis has been confirmed in some animal models. To further understand the…”
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Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells : enhanced efficacy by cotransduction of gene encoding IL-12 by CHEN, Y, EMTAGE, P, ZHU, Q, FOLEY, R, MULLER, W, HITT, M, GAULDIE, J, WAN, Y

“…Overexpression of ErbB-2/neu occurs in 20-30% of patients with breast cancer and indicates a poor prognosis. The presence of a detectable immune response to…”
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