Search Results - "GAUDETTE, Glenn R"

Bioengineering Human Myocardium on Native Extracellular Matrix by Guyette, Jacques P, Charest, Jonathan M, Mills, Robert W, Jank, Bernhard J, Moser, Philipp T, Gilpin, Sarah E, Gershlak, Joshua R, Okamoto, Tatsuya, Gonzalez, Gabriel, Milan, David J, Gaudette, Glenn R, Ott, Harald C

“…RATIONALE:More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States…”
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Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds by Gershlak, J, Hernandez, S, Fontana, G, Perreault, L, Hansen, K, Larson, S, Binder, B, Dolivo, D, Yang, T, Dominko, T, Rolle, M, Weathers, P, Medina-Bolivar, F, Cramer, C, Murphy, W, Gaudette, G

“…Abstract Despite significant advances in the fabrication of bioengineered scaffolds for tissue engineering, delivery of nutrients in complex engineered human…”
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An Edible, Decellularized Plant Derived Cell Carrier for Lab Grown Meat by Thyden, Richard, Perreault, Luke R., Jones, Jordan D., Notman, Hugh, Varieur, Benjamin M., Patmanidis, Andriana A., Dominko, Tanja, Gaudette, Glenn R.

“…Rapidly expanding skeletal muscle satellite cells with cost-effective methods have been presented as a solution for meeting the growing global demand for meat…”
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Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro by Potapova, Irina A., Gaudette, Glenn R., Brink, Peter R., Robinson, Richard B., Rosen, Michael R., Cohen, Ira S., Doronin, Sergey V.

“…We investigated effects of the paracrine factors secreted by human mesenchymal stem cells (hMSCs) on endothelial cell migration, extracellular matrix invasion,…”
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Development of a Contractile Cardiac Fiber From Pluripotent Stem Cell Derived Cardiomyocytes by Hansen, Katrina J, Laflamme, Michael A, Gaudette, Glenn R

“…Stem cell therapy has the potential to regenerate cardiac function after myocardial infarction. In this study, we sought to examine if fibrin microthread…”
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Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle by West, Adrian R, Zaman, Nishat, Cole, Darren J, Walker, Matthew J, Legant, Wesley R, Boudou, Thomas, Chen, Christopher S, Favreau, John T, Gaudette, Glenn R, Cowley, Elizabeth A, Maksym, Geoffrey N

“…Airway smooth muscle (ASM) cellular and molecular biology is typically studied with single-cell cultures grown on flat 2D substrates. However, cells in vivo…”
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Inflammation Effects on the Electrical Properties of Atrial Tissue and Inducibility of Postoperative Atrial Fibrillation by Tselentakis, E. Victor, Woodford, Edward, Chandy, Joby, Gaudette, Glenn R., Saltman, Adam E.

“…Atrial fibrillation is the most common complication after cardiac surgery. Postoperative atrial fibrillation (PAF) has been shown to increase length of stay,…”
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Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function by KOCHUPURA, Paul V, AZELOGLU, Evren U, KELLY, Damon J, DORONIN, Sergey V, BADYLAK, Stephen F, KRUKENKAMP, Irvin B, COHEN, Ira S, GAUDETTE, Glenn R

“…Extracellular matrix (ECM), a tissue-engineered scaffold, recently demonstrated cardiomyocyte population after myocardial implantation. Surgical restoration of…”
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Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model by Favreau, John T., BS, Nguyen, Binh T., MD, Gao, Ian, BS, Yu, Peng, MD, Tao, Ming, MD, Schneiderman, Jacob, MD, Gaudette, Glenn R., PhD, Ozaki, C. Keith, MD

“…Objective The underlying causes of abdominal aortic aneurysms (AAAs) remain obscure, although research tools such as the angiotensin II (Ang II) apolipoprotein…”
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Acute reductions in mechanical wall strain precede the formation of intimal hyperplasia in a murine model of arterial occlusive disease by Favreau, John T., ME, Liu, Chengwei, MD, PhD, Yu, Peng, MD, PhD, Tao, Ming, MD, Mauro, Christine, MD, Gaudette, Glenn R., PhD, Ozaki, C. Keith, MD

“…Objective Intimal hyperplasia (IH) continues to plague the durability of vascular interventions. Employing a validated murine model, ultrasound biomicroscopy,…”
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The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium by Badylak, Stephen F, Kochupura, Paul V, Cohen, Ira S, Doronin, Sergey V, Saltman, Adam E, Gilbert, Thomas W, Kelly, Damon J, Ignotz, Ronald A, Gaudette, Glenn R

“…Regenerative medicine approaches for the treatment of damaged or missing myocardial tissue include cell-based therapies, scaffold-based therapies, and/or the…”
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Applying controlled non-uniform deformation for in vitro studies of cell mechanobiology by Balestrini, Jenna L., Skorinko, Jeremy K., Hera, Adriana, Gaudette, Glenn R., Billiar, Kristen L.

“…Cells within connective tissues routinely experience a wide range of non-uniform mechanical loads that regulate many cell behaviors. In this study, we…”
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After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology by Hutcheson, Joshua D, Goergen, Craig J, Schoen, Frederick J, Aikawa, Masanori, Zilla, Peter, Aikawa, Elena, Gaudette, Glenn R

“…The first successful heart transplant 50 years ago by Dr.Christiaan Barnard in Cape Town, South Africa revolutionized cardiovascular medicine and research…”
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Creation of a contractile biomaterial from a decellularized spinach leaf without ECM protein coating: An in vitro study by Robbins, Emily R., Pins, George D., Laflamme, Michael A., Gaudette, Glenn R.

“…Myocardial infarction (MI) results in the death of cardiac tissue, decreases regional contraction, and can lead to heart failure. Tissue engineered cardiac…”
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Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation by Kelly, Damon J, Rosen, Amy B, Schuldt, Adam J T, Kochupura, Paul V, Doronin, Sergey V, Potapova, Irina A, Azeloglu, Evren U, Badylak, Stephen F, Brink, Peter R, Cohen, Ira S, Gaudette, Glenn R

“…During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the…”
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Micropatterned fibrin scaffolds increase cardiomyocyte alignment and contractility for the fabrication of engineered myocardial tissue by English, Elizabeth J., Samolyk, Bryanna L., Gaudette, Glenn R., Pins, George D.

“…Cardiovascular disease is the leading cause of death in the United States, which can result in blockage of a coronary artery, triggering a myocardial…”
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Functional Effects of Delivering Human Mesenchymal Stem Cell-Seeded Biological Sutures to an Infarcted Heart by Hansen, Katrina J, Favreau, John T, Guyette, Jacques P, Tao, Ze-Wei, Coffin, Spencer T, Cunha-Gavidia, Anny, D'Amore, Brian, Perreault, Luke R, Fitzpatrick, John P, DeMartino, Angelica, Gaudette, Glenn R

“…Stem cell therapy has the potential to improve cardiac function after myocardial infarction (MI); however, existing methods to deliver cells to the myocardium,…”
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Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides by Gao, Junyuan, Wymore, Randy S, Wang, Yongli, Gaudette, Glenn R, Krukenkamp, Irvin B, Cohen, Ira S, Mathias, Richard T

“…It is well-known that micromolar to millimolar concentrations of cardiac glycosides inhibit Na/K pump activity, however, some early reports suggested nanomolar…”
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Myocardial Recovery from Ischemia Is Impaired in CD36-Null Mice and Restored by Myocyte CD36 Expression or Medium-Chain Fatty Acids by Irie, Hiroshi, Krukenkamp, Irvin B., Joep F. F. Brinkmann, Gaudette, Glenn R., Saltman, Adam E., Jou, William, Jan F. C. Glatz, Abumrad, Nada A., Ibrahimi, Azeddine

“…Long-chain fatty acid uptake, which provides a large part of myocardial energy, is impaired in human and murine hearts deficient in the membrane fatty acid…”
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Accuracy and reproducibility of a subpixel extended phase correlation method to determine micron level displacements in the heart by Kelly, Damon J, Azeloglu, Evren U, Kochupura, Paul V, Sharma, Gaurav S, Gaudette, Glenn R

“…Abstract Future treatment of heart disease may involve local perturbations of mechanical function, such as intramyocardial injections of angiogenic growth…”
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