Search Results - "GAUDET, Rachelle"

Advances in TRP channel drug discovery: from target validation to clinical studies by Koivisto, Ari-Pekka, Belvisi, Maria G., Gaudet, Rachelle, Szallasi, Arpad

“…Transient receptor potential (TRP) channels are multifunctional signalling molecules with many roles in sensory perception and cellular physiology. Therefore,…”
Get full text

Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters by Srikant, Sriram, Gaudet, Rachelle

“…Much structural information has been amassed on ATP-binding cassette (ABC) transporters, including hundreds of structures of isolated domains and an increasing…”
Get full text

TRP channels entering the structural era by Gaudet, Rachelle

“…Transient receptor potential (TRP) channels are important in many neuronal and non-neuronal physiological processes. The past 2 years have seen much progress…”
Get full text

Molecular Mechanism of Nramp-Family Transition Metal Transport by Bozzi, Aaron T., Gaudet, Rachelle

“…[Display omitted] •Nramp transporters import transition metal ions in many physiological contexts.•Nramps adopt a LeuT fold with adaptations including an…”
Get full text

A primer on ankyrin repeat function in TRP channels and beyond by Gaudet, Rachelle

“…Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues…”
Get more information

Structural and functional diversity calls for a new classification of ABC transporters by Thomas, Christoph, Aller, Stephen G., Beis, Konstantinos, Carpenter, Elisabeth P., Chang, Geoffrey, Chen, Lei, Dassa, Elie, Dean, Michael, Duong Van Hoa, Franck, Ekiert, Damian, Ford, Robert, Gaudet, Rachelle, Gong, Xin, Holland, I. Barry, Huang, Yihua, Kahne, Daniel K., Kato, Hiroaki, Koronakis, Vassilis, Koth, Christopher M., Lee, Youngsook, Lewinson, Oded, Lill, Roland, Martinoia, Enrico, Murakami, Satoshi, Pinkett, Heather W., Poolman, Bert, Rosenbaum, Daniel, Sarkadi, Balazs, Schmitt, Lutz, Schneider, Erwin, Shi, Yigong, Shyng, Show‐Ling, Slotboom, Dirk J., Tajkhorshid, Emad, Tieleman, D. Peter, Ueda, Kazumitsu, Váradi, András, Wen, Po‐Chao, Yan, Nieng, Zhang, Peng, Zheng, Hongjin, Zimmer, Jochen, Tampé, Robert

“…Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous…”
Get full text

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? by Perálvarez‐Marín, Alex, Doñate‐Macian, Pau, Gaudet, Rachelle

“…Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by…”
Get full text

Applications of sequence coevolution in membrane protein biochemistry by Nicoludis, John M., Gaudet, Rachelle

“…Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global…”
Get full text

Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction by Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.

“…A combination of structural, computational and biophysical tools is used to characterize the bond between tip-link proteins protocadherin 15 and cadherin 23,…”
Get full text

Sorting out a promiscuous superfamily: towards cadherin connectomics by Sotomayor, Marcos, Gaudet, Rachelle, Corey, David P

“…Highlights • Cadherin proteins and their interactions are essential for multicellular life. • Physical interaction among cadherins is more complex than…”
Get full text

Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel by Inada, Hitoshi, Procko, Erik, Sotomayor, Marcos, Gaudet, Rachelle

“…The TRPV4 calcium-permeable cation channel plays important physiological roles in osmosensation, mechanosensation, cell barrier formation, and bone…”
Get full text

Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel by Lau, Sze-Yi, Procko, Erik, Gaudet, Rachelle

“…Transient receptor potential (TRP) vanilloid 1 (TRPV1) is a molecular pain receptor belonging to the TRP superfamily of nonselective cation channels. As a…”
Get full text

Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter by Bozzi, Aaron T, Zimanyi, Christina M, Nicoludis, John M, Lee, Brandon K, Zhang, Casey H, Gaudet, Rachelle

“…Nramp family transporters-expressed in organisms from bacteria to humans-enable uptake of essential divalent transition metals via an alternating-access…”
Get full text

Advances in TRP channel drug discovery: from target validation to clinical studies by Koivisto, Ari-Pekka, Belvisi, Maria G., Gaudet, Rachelle, Szallasi, Arpad

Get full text

Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters by Bozzi, Aaron T., Bane, Lukas B., Weihofen, Wilhelm A., McCabe, Anne L., Singharoy, Abhishek, Chipot, Christophe J., Schulten, Klaus, Gaudet, Rachelle

“…Natural resistance-associated macrophage protein (Nramp) family transporters catalyze uptake of essential divalent transition metals like iron and manganese…”
Get full text

The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity by Lishko, Polina V., Procko, Erik, Jin, Xiangshu, Phelps, Christopher B., Gaudet, Rachelle

“…TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation. We describe the…”
Get full text

High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter by Ray, Shamayeeta, Berry, Samuel P, Wilson, Eric A, Zhang, Casey H, Shekhar, Mrinal, Singharoy, Abhishek, Gaudet, Rachelle

“…Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By…”
Get full text

Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain by Phelps, Christopher B., Wang, Ruiqi R., Choo, Shelly S., Gaudet, Rachelle

“…Transient receptor potential vanilloid (TRPV) channels, which include the thermosensitive TRPV1–V4, have large cytoplasmic regions flanking the transmembrane…”
Get full text

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli by Garcia-Elias, Anna, Mrkonjic, Sanela, Pardo-Pastor, Carlos, Inada, Hitoshi, Hellmich, Ute A., Rubio-Moscardó, Fanny, Plata, Cristina, Gaudet, Rachelle, Vicente, Rubén, Valverde, Miguel A.

“…Most transient receptor potential (TRP) channels are regulated by phosphatidylinositol-4,5-biphosphate (PIP ₂), although the structural rearrangements…”
Get full text

Structural Determinants of Cadherin-23 Function in Hearing and Deafness by Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.

“…The hair-cell tip link, a fine filament directly conveying force to mechanosensitive transduction channels, is composed of two proteins, protocadherin-15 and…”
Get full text