Search Results - "GATES, S. B"

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes by SHIH, C, CHEN, V. J, ANDIS, S. L, BEWLEY, J. R, RAYL, E. A, MOROSON, B. A, BEARDSLEY, G. P, KOHLER, W, RATNAM, M, SCHULTZ, R. M, GOSSETT, L. S, GATES, S. B, MACKELLAR, W. C, HABECK, L. L, SHACKELFORD, K. A, MENDELSOHN, L. G, SOOSE, D. J, PATEL, V. F

“…N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyrimidine-based…”
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Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis by Mendelsohn, L G, Shih, C, Chen, V J, Habeck, L L, Gates, S B, Shackelford, K A

“…The pyrrolopyrimidine-based antifolate, N-¿4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]benzoyl¿glutamic acid, LY231514 (MTA) has…”
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Sulfonimidamide analogs of oncolytic sulfonylureas by TOTH, J. E, GRINDEY, G. B, WEIR, L. C, WORZALLA, J. F, EHLHARDT, W. J, RAY, J. E, BODER, G. B, BEWLEY, J. R, KLINGERMAN, K. K, GATES, S. B, RINZEL, S. M, SCHULTZ, R. M

“…A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in…”
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Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression by GATES, S. B, MENDELSOHN, L. G, SHACKELFORD, K. A, HABECK, L. L, KURSAR, J. D, GOSSETT, L. S, WORZALLA, J. F, SHIH, C, GRINDEY, G. B

“…Membrane-associated folate receptors (FRs) have been detected in many mammalian species, and multiple isoforms have been identified. The pharmacological…”
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Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts by Gates, Susan B., Worzalla, John F., Shih, Chuan, Grindey, Gerald B., Mendelsohn, Laurane G.

“…The importance of polyglutamation for the activation of natural folates and classical antifolates and recent evidence for the role of dietary folate as a…”
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Effect of endogenous and exogenous polyamines on organic cation transport in rabbit renal plasma membrane vesicles by Sokol, P P, Gates, S B

“…The effect of several polyamines on the transport of organic cations [N1-[3H]methylnicotinamide (NMN), [3H]NMN and 3H-tetraethylammonium, ([3H]TEA)] in rabbit…”
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The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3- D]pyrimidine based antifolates as antineoplastic and antiarthritic agents by Gossett, Lynn S., Habeck, Lillian L., Shackelford, Katherine A., Mendelsohn, Laurane G., Gates, Susan B., Worzalla, John F., Self, Tracy D., Theobald, Karla S., Andis, Sherri L., Schultz, Richard M., Shih, Chuan

“…A new series of 2,4-diaminopyrido[2,3- d]pyrimidine based antifolates 1–3 were synthesized through an efficient conversion of…”
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Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases by Sayre, Peter H, Finer-Moore, Janet S, Fritz, Timothy A, Biermann, Donna, Gates, Susan B, MacKellar, Warren C, Patel, Vinod F, Stroud, Robert M

“…Crystal structures of four pyrrolo(2,3-d)pyrimidine-based antifolate compounds, developed as inhibitors of thymidylate synthase (TS) in a strategy to…”
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Role of membrane-associated folate binding protein in the cytotoxicity of antifolates in KB, IGROV1, and L1210A cells by Schultz, R M, Andis, S L, Shackelford, K A, Gates, S B, Ratnam, M, Mendelsohn, L G, Shih, C, Grindey, G B

“…Based on differential levels of membrane-associated folate binding protein (mFBP) expression, murine L1210 leukemia, human KB epidermoid carcinoma, and human…”
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Trailing‐edge Flaps: A General Review of the Purpose of Flaps and How, and How Far, They Achieve It by Gates, S.B.

“…THE reader who asks for more wood and less trees in technical discussions of wing flaps has my sympathy, since I have myself been responsible for some…”
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The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol by Mendelsohn, Laurane G., Gates, Susan B., Habeck, Lillian L., Shackelford, Katherine A., Worzalla, John, Shih, Chuan, Grindey, Gerald B.

“…We have studied the molecular effects of a LFD in a murine model in order to better define the biochemical changes associated with folate deficiency. In…”
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The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine by Tonkinson, J L, Habeck, L L, Toth, J E, Mendelsohn, L G, Bewley, J, Shackelford, K A, Gates, S B, Ray, J, Chen, V J

“…5,6,7,8-Tetrahydro-N5,N10-carbonylfolic acid (LY354899) has been demonstrated to inhibit the dehydrogenase activity of C1-tetrahydrofolate synthase. This…”
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Longitudinal Stability and Control: A Simple Exposition of the Fundamentals Employed in this Aspect of Design by Gates, S.B.

“…IN these notes I have attempted to describe the main features of longitudinal stability and control in the simplest possible terms, omitting the mathematical…”
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Herbert Brian Squire. 1909-1961 by Gates, S. B., Young, A. D.

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Herbert Brian Squire by Gates, S B, Young, A D

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Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure by Gossett, Lynn S., Habeck, Lillian L., Gates, Susan B., Andis, Sherri L., Worzalla, John F., Schultz, Richard M., Mendelsonn, Laurane G., Kohler, William, Ratnam, Manohar, Grindey, Gerald B., Shih, Chuan

“…A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological…”
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Defensive Social Workers by Gates, Bruce S.

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