Search Results - "GATENBY, Robert"

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand by Epstein, Tamir, Gatenby, Robert A, Brown, Joel S

“…To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term…”
Get full text

A change of strategy in the war on cancer by Gatenby, Robert A

“…Patients and politicians anxiously await and increasingly demand a 'cure' for cancer. But trying to control the disease may prove a better plan than striving…”
Get full text

Integrating evolutionary dynamics into cancer therapy by Gatenby, Robert A., Brown, Joel S.

“…Many effective drugs for metastatic and/or advanced-stage cancers have been developed over the past decade, although the evolution of resistance remains the…”
Get full text

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work by Gillies, Robert J., Verduzco, Daniel, Gatenby, Robert A.

“…All malignant cancers, whether inherited or sporadic, are fundamentally governed by Darwinian dynamics and consist of dynamically evolving clades of cells…”
Get full text

Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer by Zhang, Jingsong, Cunningham, Jessica J., Brown, Joel S., Gatenby, Robert A.

“…Abiraterone treats metastatic castrate-resistant prostate cancer by inhibiting CYP17A, an enzyme for testosterone auto-production. With standard dosing,…”
Get full text

Quantitative imaging in cancer evolution and ecology by Gatenby, Robert A, Grove, Olya, Gillies, Robert J

“…Cancer therapy, even when highly targeted, typically fails because of the remarkable capacity of malignant cells to evolve effective adaptations. These…”
Get full text

The Role of Cell Membrane Information Reception, Processing, and Communication in the Structure and Function of Multicellular Tissue by Gatenby, Robert A

“…Investigations of information dynamics in eukaryotic cells focus almost exclusively on heritable information in the genome. Gene networks are modeled as…”
Get full text

The Evolution and Ecology of Resistance in Cancer Therapy by Gatenby, Robert, Brown, Joel

“…Despite continuous deployment of new treatment strategies and agents over many decades, most disseminated cancers remain fatal. Cancer cells, through their…”
Get full text

Characterizing the ecological and evolutionary dynamics of cancer by Zahir, Nastaran, Sun, Ruping, Gallahan, Daniel, Gatenby, Robert A., Curtis, Christina

“…Tumor initiation and progression are somatic evolutionary processes driven by the accumulation of genetic alterations, some of which confer selective fitness…”
Get full text

Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer by Gatenby, Robert A., Brown, Joel

“…The origin and progression of cancer is widely viewed as “somatic evolution” driven by the accumulation of random genetic changes. This theoretical model,…”
Get full text

Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy by Strobl, Maximilian A R, West, Jeffrey, Viossat, Yannick, Damaghi, Mehdi, Robertson-Tessi, Mark, Brown, Joel S, Gatenby, Robert A, Maini, Philip K, Anderson, Alexander R A

“…Adaptive therapy seeks to exploit intratumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising…”
Get full text

Quantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinoma by Grove, Olya, Berglund, Anders E, Schabath, Matthew B, Aerts, Hugo J W L, Dekker, Andre, Wang, Hua, Velazquez, Emmanuel Rios, Lambin, Philippe, Gu, Yuhua, Balagurunathan, Yoganand, Eikman, Edward, Gatenby, Robert A, Eschrich, Steven, Gillies, Robert J

“…Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density…”
Get full text

First Strike-Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction by Gatenby, Robert A, Zhang, Jingsong, Brown, Joel S

“…While clinical cancer research has produced many highly effective drugs, the diversity and evolutionary capacity of most cancer populations remain…”
Get full text

Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes by Zhang, Jingsong, Cunningham, Jessica, Brown, Joel, Gatenby, Robert

“…Abiraterone acetate is an effective treatment for metastatic castrate-resistant prostate cancer (mCRPC), but evolution of resistance inevitably leads to…”
Get full text

Acidity Generated by the Tumor Microenvironment Drives Local Invasion by ESTRELLA, Veronica, TINGAN CHEN, JOHNSON, Joseph, GATENBY, Robert A, GILLIES, Robert J, LLOYD, Mark, WOJTKOWIAK, Jonathan, CORNNELL, Heather H, IBRAHIM-HASHIM, Arig, BAILEY, Kate, BALAGURUNATHAN, Yoganand, ROTHBERG, Jennifer M, SLOANE, Bonnie F

“…The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive…”
Get full text

Is the Genetic Paradigm of Cancer Complete? by Gatenby, Robert A

Get full text

Beyond Mammography: New Frontiers in Breast Cancer Screening by Drukteinis, Jennifer S., MD, Mooney, Blaise P., MD, Flowers, Chris I., MBBS, Gatenby, Robert A., MD

“…Abstract Breast cancer screening remains a subject of intense and, at times, passionate debate. Mammography has long been the mainstay of breast cancer…”
Get full text

Causes and consequences of increased glucose metabolism of cancers by Gillies, Robert J, Robey, Ian, Gatenby, Robert A

“…In this review we examine the mechanisms (causes) underlying the increased glucose consumption observed in tumors within a teleological context (consequences)…”
Get full text

Optimal control to develop therapeutic strategies for metastatic castrate resistant prostate cancer by Cunningham, Jessica J., Brown, Joel S., Gatenby, Robert A., Staňková, Kateřina

“…•Optimal control is applied to a game theoretic model of prostate cancer treatment.•Current clinical treatment schedules are compared to novel optimized…”
Get full text

Application of Evolutionary Principles to Cancer Therapy by Enriquez-Navas, Pedro M, Wojtkowiak, Jonathan W, Gatenby, Robert A

“…The dynamic cancer ecosystem, with its rich temporal and spatial diversity in environmental conditions and heritable cell phenotypes, is remarkably robust to…”
Get full text