Search Results - "GATBONTON, Tonibelle"

Current Landscape of NRF2 Biomarkers in Clinical Trials by Yagishita, Yoko, Gatbonton-Schwager, Tonibelle N, McCallum, Melissa L, Kensler, Thomas W

“…The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by ) plays a critical role in the maintenance of cellular redox and metabolic homeostasis,…”
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Identification of 1600 replication origins in S. cerevisiae by Foss, Eric J, Lichauco, Carmina, Gatbonton-Schwager, Tonibelle, Gonske, Sara J, Lofts, Brandon, Lao, Uyen, Bedalov, Antonio

“…There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well…”
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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes by HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

“…SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of…”
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Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast by Gatbonton, Tonibelle, Imbesi, Maria, Nelson, Melisa, Akey, Joshua M, Ruderfer, Douglas M, Kruglyak, Leonid, Simon, Julian A, Bedalov, Antonio

“…Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72…”
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Hst3 Is Regulated by Mec1-dependent Proteolysis and Controls the S Phase Checkpoint and Sister Chromatid Cohesion by Deacetylating Histone H3 at Lysine 56 by Thaminy, Safia, Newcomb, Benjamin, Kim, Jessica, Gatbonton, Tonibelle, Foss, Eric, Simon, Julian, Bedalov, Antonio

“…The SIR2 homologues HST3 and HST4 have been implicated in maintenance of genome integrity in the yeast Saccharomyces cerevisiae. We find that Hst3 has…”
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Identification of a Small Molecule Inhibitor of Sir2p by Bedalov, Antonio, Gatbonton, Tonibelle, Irvine, William P., Gottschling, Daniel E., Simon, Julian A.

“…Sir2p is an NAD+-dependent histone deacetylase required for chromatin-dependent silencing in yeast. In a cell-based screen for inhibitors of Sir2p, we…”
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Chromosomal Mcm2-7 distribution and the genome replication program in species from yeast to humans by Foss, Eric J, Sripathy, Smitha, Gatbonton-Schwager, Tonibelle, Kwak, Hyunchang, Thiesen, Adam H, Lao, Uyen, Bedalov, Antonio

“…The spatio-temporal program of genome replication across eukaryotes is thought to be driven both by the uneven loading of pre-replication complexes (pre-RCs)…”
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Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats by Foss, Eric J, Gatbonton-Schwager, Tonibelle, Thiesen, Adam H, Taylor, Erin, Soriano, Rafael, Lao, Uyen, MacAlpine, David M, Bedalov, Antonio

“…Repetitive DNA sequences within eukaryotic heterochromatin are poorly transcribed and replicate late in S-phase. In Saccharomyces cerevisiae, the histone…”
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Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion by Adrianse, Robin L, Smith, Kaleb, Gatbonton-Schwager, Tonibelle, Sripathy, Smitha P, Lao, Uyen, Foss, Eric J, Boers, Ruben G, Boers, Joachim B, Gribnau, Joost, Bedalov, Antonio

“…The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear…”
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Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal by Gatbonton-Schwager, Tonibelle N, Sadhukhan, Sushabhan, Zhang, Guo-Fang, Letterio, John J, Tochtrop, Gregory P

“…4-Hydroxy-2-(E)-nonenal (4-HNE) is one of the major lipid peroxidation product formed during oxidative stress. At high concentrations, 4-HNE is cytotoxic and…”
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Bryonolic Acid Transcriptional Control of Anti-inflammatory and Antioxidant Genes in Macrophages in Vitro and in Vivo by Gatbonton-Schwager, Tonibelle N, Letterio, John J, Tochtrop, Gregory P

“…Bryonolic acid (BA) (1) is a naturally occurring triterpenoid with pleiotropic properties. This study characterizes the mechanisms mediating the…”
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Correction: Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast by Gatbonton, Tonibelle, Imbesi, Maria, Nelson, Melisa, Akey, Joshua M, Ruderfer, Douglas M, Kruglyak, Leonid, Simon, Julian A, Bedalov, Antonio

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Bryonolic Acid: A Large-Scale Isolation and Evaluation of Heme Oxygenase 1 Expression in Activated Macrophages by Barker, Emily C, Gatbonton-Schwager, Tonibelle N, Han, Yong, Clay, Jennifer E, Letterio, John J, Tochtrop, Gregory P

“…Bryonolic acid (BA) is a triterpenoid found in the Cucurbitaceae family of plants. Our interests in the immunomodulatory effects of this class of natural…”
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A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me) by Gatbonton-Schwager, Tonibelle, Yagishita, Yoko, Joshi, Tanvi, Wakabayashi, Nobunao, Srinivasan, Harini, Suzuki, Takafumi, Yamamoto, Masayuki, Kensler, Thomas W

“…Bardoxolone methyl (CDDO-Me) is an oleanane triterpenoid in late-stage clinical development for the treatment of patients with diabetic kidney disease…”
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Identification of 1600 replication origins in S. cerevisiae by Foss, Eric J, Lichauco, Carmina, Gatbonton-Schwager, Tonibelle, Gonske, Sara J, Lofts, Brandon, Lao, Uyen, Bedalov, Antonio

“…There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well…”
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Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression by Sripathy, Smitha, Leko, Vid, Adrianse, Robin L., Loe, Taylor, Foss, Eric J., Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T., Payer, Bernhard, Paddison, Patrick J., Grady, William M., Lee, Jeannie T., Bartolomei, Marisa S., Bedalov, Antonio

“…Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with heterozygous mutations in the gene encoding the methyl-CpG–binding…”
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Abstract 3225: Profiling the DNA regulome to discover direct inhibitors of the brachyury transcription factor by Federation, Alexander Joel, Gao, Yang, McEllin, Brian, Gatbonton-Schwager, Tonibelle, Gutierrez, Andrea, Robbins, Julia, Hueffmeier, Bodhi, Broderick, Erin, Canzani, Daniele, Fondrie, William, Pino, Lindsay

“…Abstract Background: The human genome encodes more than 1,600 transcription factors (TFs), along with additional cofactors, chromatin regulators, and…”
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Correction: telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast by Gatbonton, Tonibelle, Imbesi, Maria, Nelson, Melisa, Akey, Joshua M, Ruderfer, Douglas M, Kruglyak, Leonid, Simon, Julian A, Bedalov, Antonio

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Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-[Beta] superfamily as a regulator of XIST expression by Sripathy, Smitha, Leko, Vid, Adrianse, Robin L, Loe, Taylor, Foss, Eric J, Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T, Payer, Bernhard, Paddison, Patrick J, Grady, William M, Lee, Jeannie T, Bartolomei, Marisa S, Bedalov, Antonio

“…Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with heterozygous mutations in the gene encoding the methyl-CpG-binding…”
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Biological and Chemical Analysis of Small Molecule Activators of Anti-Inflammatory and Antioxidant Nrf2-Keap1 Signaling by Gatbonton-Schwager, Tonibelle Nicolay

“…The immune system provides a cellular defense mechanism against harmful agents in the form of inflammatory and antioxidant responses mediated by the Nrf2-Keap1…”
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