Search Results - "GASDASKA, P"

Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia by Berggren, M, Gallegos, A, Gasdaska, J R, Gasdaska, P Y, Warneke, J, Powis, G

“…Thioredoxin and thioredoxin reductase are redox proteins that have been implicated in the control of cell proliferation and transformation. We report the…”
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Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells by GALLEGOS, A, GASDASKA, J. R, TAYLOR, C. W, PAINE-MURRIETA, G. D, GOODMAN, D, GASDASKA, P. Y, BERGGREN, M, BRIEHL, M. M, POWIS, G

“…Thioredoxin, a redox protein with growth factor activity that modulates the activity of several proteins important for cell growth, has been reported to be…”
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Dominant effects of tubulin overexpression in Saccharomyces cerevisiae by BURKE, D, GASDASKA, P, HARTWELL, L

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin by OBLONG, J. E, BERGGREN, M, GASDAKSA, P. Y, POWIS, G

“…Thioredoxin and thioredoxin reductase comprise a redox system ubiquitous in all organisms. To better understand the thiol chemistry of the mammalian…”
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Cloning and sequencing of a human thioredoxin reductase by Gasdaska, Pamela Y., Gasdaska, John R., Cochran, Shawn, Powis, Garth

“…The DNA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading…”
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Regulation of Human Thioredoxin Reductase Expression and Activity by 3′-Untranslated Region Selenocysteine Insertion Sequence and mRNA Instability Elements by Gasdaska, John R., Harney, John W., Gasdaska, Pamela Y., Powis, Garth, Berry, Marla J.

“…Thioredoxin reductases function in regulating cellular redox and function through their substrate, thioredoxin, in the proper folding of enzymes and redox…”
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Purification of human thioredoxin reductase: Properties and characterization by absorption and circular dichroism spectroscopy by Oblong, John E, Gasdaska, Pamela Y, Sherrill, Kyle, Powis, Garth

“…The flavoenzyme thioredoxin reductase (TR) and its natural substrate thioredoxin comprise a redox system generally found in all organisms. In order to better…”
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Cloning, sequencing and functional expression of a novel human thioredoxin reductase by Gasdaska, Pamela Y., Berggren, Margareta M., Berry, Marla J., Powis, Garth

“…The DNA sequence encoding a novel human thioredoxin reductase has been determined. The protein is predicted to have 524 amino acids including a conserved…”
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Human Thioredoxin Reductase Gene Localization to Chromosomal Position 12q23–q24.1 and mRNA Distribution in Human Tissue by Gasdaska, John R., Gasdaska, Pamela Y., Gallegos, Alfred, Powis, Garth

“…Thioredoxin reductase is a member of the pyridine nucleotide–disulfide oxidoreductase family of enzymes. By delivering reducing equivalents to thioredoxin,…”
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Over-expression of DT-diaphorase in transfected NIH 3T3 cells does not lead to increased anticancer quinone drug sensitivity: a questionable role for the enzyme as a target for bioreductively activated anticancer drugs by Powis, G, Gasdaska, P Y, Gallegos, A, Sherrill, K, Goodman, D

“…Murine NIH 3T3 cells were stably transfected with human NQO1 (DT-diaphorase) cDNA and clonal cell lines with up to 15-fold elevated DT-diaphorase activity were…”
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The thioredoxin/thioredoxin reductase redox system and control of cell growth by Powis, G, Oblong, J E, Gasdaska, P Y, Berggren, M, Hill, S R, Kirkpatrick, D L

“…Thioredoxin is a redox protein that is important for a variety of intracellular functions, possibly including regulation of transcription factor activity. We…”
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Cigarette smoking is a determinant of DT-diaphorase gene expression in human non-small cell lung carcinoma by GASDASKA, P. Y, POWIS, G, HYMAN, P, FISHER, H

“…The levels of NAD(P)H:(quinone-acceptor) oxidoreductase (EC.1.6.99.2) (DT-diaphorase) mRNA and enzyme activity have been studied in paired human normal lung…”
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Selenium and the thioredoxin redox system: effects on cell growth and death by Powis, G, Gasdaska, J R, Gasdaska, P Y, Berggren, M, Kirkpatrick, D L, Engman, L, Cotgreave, I A, Angulo, M, Baker, A

“…Thioredoxin is a redox protein found overexpressed in some human tumors. Thioredoxin is secreted by tumor cells and enhances the sensitivity of the cancer…”
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An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues by Gasdaska, P Y, Fisher, H, Powis, G

“…DT-diaphorase is a ubiquitously expressed flavoenzyme responsible for the two-electron reduction of a number of quinone and other anticancer drugs. The…”
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An alternatively spliced form of NQQ1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues by GASDASKA, P. Y, FISHER, H, POWIS, G

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Site-directed mutagenesis of Lys super(36) in human thioredoxin: The highly conserved residue affects reduction rates and growth stimulation but is not essential for the redox protein's biochemical or biological properties by Oblong, JE, Berggren, M, Gasdaska, P Y, Hill, SR, Powis, G

“…Previous studies have demonstrated that a recombinant form of the human redox protein thioredoxin can stimulate the growth rate of Swiss 3T3 murine fibroblasts…”
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Increased NAD(P)H : (quinone-acceptor)oxidoreductase activity is associated with density-dependent growth inhibition of normal but not transformed cells by SCHLAGER, J. J, HOERL, B. J, RIEBOW, J, SCOTT, D. P, GASDASKA, P, SCOTT, R. E, POWIS, G

“…The activity of DT-diaphorase [NAD(P)H:(quinone-acceptor)oxidoreductase] is increased 7-fold in wild-type BALB/c 3T3T cells as they reach confluence and become…”
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Site-Directed Mutagenesis of Lys36 in Human Thioredoxin: The Highly Conserved Residue Affects Reduction Rates and Growth Stimulation but Is Not Essential for the Redox Protein's Biochemical or Biological Properties by Oblong, John E, Berggren, Margareta, Gasdaska, Pamela Y, Hill, Simon R, Powis, Garth

“…Previous studies have demonstrated that a recombinant form of the human redox protein thioredoxin can stimulate the growth rate of Swiss 3T3 murine fibroblasts…”
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The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors by Gasdaska, P Y, Oblong, J E, Cotgreave, I A, Powis, G

“…The cDNA sequences of thioredoxin obtained by PCR cloning from human colon cancer cells, human lymphoblastoid cells, and human liver have been found to be…”
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