Search Results - "GARNER, R. C"

Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing by Combes, R.D, Berridge, T, Connelly, J, Eve, M.D, Garner, R.C, Toon, S, Wilcox, P

“…Testing the safety and efficacy of a successful human medicine involves many laboratory animals, which can sometimes be subjected to considerable suffering and…”
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Pediatric microdose and microtracer studies using 14C in Europe by Turner, MA, Mooij, MG, Vaes, WHJ, Windhorst, AD, Hendrikse, NH, Knibbe, CAJ, Kõrgvee, LT, Maruszak, W, Grynkiewicz, G, Garner, RC, Tibboel, D, Park, BK, de Wildt, SN

“…Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and…”
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Accelerator Mass Spectrometry Measurement of Intracellular Concentrations of Active Drug Metabolites in Human Target Cells In Vivo by Chen, J, Garner, R C, Lee, L S, Seymour, M, Fuchs, E J, Hubbard, W C, Parsons, T L, Pakes, G E, Fletcher, C V, Flexner, C

“…Accelerator mass spectrometry (AMS) is an ultrasensitive technique to detect radiolabeled compounds. We administered a microdose (100 µg) of 14C‐labeled…”
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Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry by Beumer, J H, Garner, R C, Cohen, M B, Galbraith, S, Duncan, G F, Griffin, T, Beijnen, J H, Schellens, J H M

“…Ixabepilone (BMS-247550) is a semi-synthetic, microtubule stabilizing epothilone B analogue which is more potent than taxanes and has displayed activity in…”
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Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom by Barker, J., Garner, R. C.

“…Accelerator mass spectrometry (AMS) is a nuclear physics technique developed about twenty years ago, that uses the high energy (several MeV) of a tandem Van de…”
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Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein by Lappin, G., Garner, R.C., Meyers, T., Powell, J., Varley, P.

“…Although 14C-labelling has been routinely used for small molecules, this technique is not routinely applied to therapeutic proteins due to difficulties of…”
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Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer by Barrett, J.H., Smith, G., Waxman, R., Gooderham, N., Lightfoot, T., Garner, R.C., Augustsson, K., Wolf, C.R., Bishop, D.T., Forman, D.

“…Fast N-acetyltransferase 2 (NAT2) acetylators may be at increased risk of colorectal cancer through the activation of carcinogenic heterocyclic amines (HA),…”
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Determination of the Bioavailability of [14C]-Hexaminolevulinate Using Accelerator Mass Spectrometry After Intravesical Administration to Human Volunteers by Klem, B., Lappin, G., Nicholson, S., van de Wetering, J., de Vries, D. E., Oosterhuis, B., Garner, R. C.

“…Hexaminolevulinate (HAL) is a diagnostic agent that allows the visualization of tumor tissue in the bladder by fluorescence cystoscopy. It is administered…”
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Accelerator mass spectrometry in pharmaceutical research and development--a new ultrasensitive analytical method for isotope measurement by Garner, R C

“…Accelerator mass spectrometry (AMS) permits the measurement of elemental isotopes at the individual atom level. The main application of AMS in drug discovery…”
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Analysis of DNA adducts by accelerator mass spectrometry in human breast tissue after administration of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine and benzo[a]pyrene by Lightfoot, T.J, Coxhead, J.M, Cupid, B.C, Nicholson, S, Garner, R.C

“…Epidemiological evidence has suggested an association between meat consumption and the risk of breast cancer. 2-Amino-1-methyl-6-phenylimidazo[4,5- b]pyridine…”
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Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses by Turteltaub, Kenneth W, Dingley, Karen H, Curtis, Kellie D, Malfatti, Michael A, Turesky, Robert J, Colin Garner, R, Felton, James S, Lang, Nicholas P

“…2-Amino-3,8-dimethylimidazo[4,5- f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) are heterocyclic amines formed during the…”
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Comparative biotransformation studies of MeIQx and PhIP in animal models and humans by Garner, R.C, Lightfoot, T.J, Cupid, B.C, Russell, D, Coxhead, J.M, Kutschera, W, Priller, A, Rom, W, Steier, P, Alexander, D.J, Leveson, S.H, Dingley, K.H, Mauthe, R.J, Turteltaub, K.W

“…MeIQx and PhIP are putative carcinogenic heterocyclic amines formed during the cooking of meat and fish. Using accelerator mass spectrometry, we have…”
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Molecular screening of multifocal transitional cell carcinoma of the bladder using p53 mutations as biomarkers by XU, X, STOWER, M. J, REID, I. N, GARNER, R. C, BURNS, P. A

“…Thirteen of 28 patients (46%) with grade 2-3 multifocal transitional cell carcinoma (TCC) of the bladder were found to have p53 mutations using DNA sequence…”
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O20 Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children by van Groen, BD, Vaes, WHJ, Park, BK, Krekels, EHJ, van Duijn, E, Kõrgvee, L-T, Maruszak, W, Grynkiewicz, G, Garner, RC, Knibbe, C, Tibboel, D, de Wildt, SN, Turner, MA

“…BackgroundDrug disposition in children may vary from adults due to age-related variation in drug metabolism, but paediatric pharmacokinetic (PK) studies are…”
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Mutations in APC, Kirsten-Ras, and p53-Alternative Genetic Pathways to Colorectal Cancer by Smith, Gillian, Carey, Francis A., Beattie, Julie, Murray J. V. Wilkie, Lightfoot, Tracy J., Coxhead, Jonathan, Garner, R. Colin, Robert J. C. Steele, Wolf, C. Roland

“…Colorectal cancer is one of the most significant causes of cancer death. A genetic model for colorectal cancer has been proposed in which the sequential…”
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Smoking-related DNA adducts in human gastric cancers by Dyke, G W, Craven, J L, Hall, R, Garner, R C

“…DNA was extracted from the tumour tissue of 26 patients (18 smokers, 8 non-smokers) undergoing surgery for gastric cancer, and analyzed for the presence of DNA…”
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Correlation of DNA adduct levels in human lung with cigarette smoking by Phillips, David H, Hewer, Alan, Martin, Carl N, Garner, R. Colin, King, Maureen M

“…Lung cancer is the most common cancer in men in the United Kingdom and the second most common in women, accounting for between 25 and 40% of all cancer deaths…”
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PS-128 The Ethics Of Microdosing Studies In Children: The Experience Of The Era-net Priomedchild Project Pamper by Crawley, F, Vaes, WHJ, Selby, A, Varendi, H, Turner, M, Park, BK, Byrne, L, Garner, RC

“…Abstract only…”
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Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses : Comparison of human subjects and F344 rats by DINGLEY, K. H, FREEMAN, S. P. H. T, NELSON, D. O, GARNER, R. C, TURTELTAUB, K. W

“…Covalent binding of the food-borne heterocyclic amine 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) to albumin and hemoglobin (Hb), 3.5-6.0 hr after…”
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Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting by Garner, R C, Garner, J V, Gregory, S, Whattam, M, Calam, A, Leong, D

“…Daflon 500 mg, is a micronized purified flavonoid fraction, containing 90% w/w diosmin and 10% w/w of flavonoids expressed as hesperidin, used clinically in…”
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