Search Results - "GARLAND, R. B"

Differential protein acetylation induced by novel histone deacetylase inhibitors by Glaser, K.B., Li, J., Pease, L.J., Staver, M.J., Marcotte, P.A., Guo, J., Frey, R.R., Garland, R.B., Heyman, H.R., Wada, C.K., Vasudevan, A., Michaelides, M.R., Davidsen, S.K., Curtin, M.L.

“…Histone deacetylase (HDAC) inhibitors induce the hyperacetylation of nucleosomal histones in carcinoma cells resulting in the expression of repressed genes…”
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Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor by Zablocki, Jeffery A, Miyano, Masateru, Garland, Robert B, Pireh, Daisy, Schretzman, Lori, Rao, Shashidhar N, Lindmark, Richard J, Panzer-Knodle, Susan G, Nicholson, Nancy S

“…Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in…”
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The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors by Steinman, Douglas H., Curtin, Michael L., Garland, Robert B., Davidsen, Steven K., Heyman, H.Robin, Holms, James H., Albert, Daniel H., Magoc, Terry J., Nagy, Ildiko B., Marcotte, Patrick A., Li, Junling, Morgan, Douglas W., Hutchins, Charles, Summers, James B.

“…A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix…”
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A stereospecific total synthesis of the anthracyclinones (.+-.)-daunomycinone and (.+-.)-isodaunomycinone by Hansen, D. W, Pappo, R, Garland, R. B

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Phenoxyphenyl Sulfone N-Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase Inhibitors by Wada, Carol K, Holms, James H, Curtin, Michael L, Dai, Yujia, Florjancic, Alan S, Garland, Robert B, Guo, Yan, Heyman, H. Robin, Stacey, Jamie R, Steinman, Douglas H, Albert, Daniel H, Bouska, Jennifer J, Elmore, Ildiko N, Goodfellow, Carole L, Marcotte, Patrick A, Tapang, Paul, Morgan, Douglas W, Michaelides, Michael R, Davidsen, Steven K

“…A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of…”
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Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770 by Curtin, Michael L., Florjancic, Alan S., Heyman, H.Robin, Michaelides, Michael R., Garland, Robert B., Holms, James H., Steinman, Douglas H., Dellaria, Joseph F., Gong, Jane, Wada, Carol K., Guo, Yan, Elmore, Ildiko B., Tapang, Paul, Albert, Daniel H., Magoc, Terrance J., Marcotte, Patrick A., Bouska, Jennifer J., Goodfellow, Carole L., Bauch, Joy L., Marsh, Kennan C., Morgan, Douglas W., Davidsen, Steven K.

“…Modification of the biphenyl portion of MMP inhibitor 2a gave analogue 2i which is greater than 1000-fold selective against MMP-2 versus MMP-1. The…”
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Broad spectrum matrix metalloproteinase inhibitors : An examination of succinamide hydroxamate inhibitors with p1 Cα gem-disubstitution by CURTIN, M. L, GARLAND, R. B, DAVIDSEN, S. K, MARCOTTE, P. A, ALBERT, D. H, MAGOC, T. J, HUTCHINS, C

“…A series of P1 C alpha gem-disubstituted succinamide hydroxamate matrix metalloproteinase inhibitors were prepared stereoselectively and evaluated in vitro for…”
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Design of orally active, non-peptide fibrinogen receptor antagonists. An evolutionary process from the RGD sequence to novel anti-platelet aggregation agents by Bovy, P R, Tjoeng, F S, Rico, J G, Rogers, T E, Lindmark, R J, Zablocki, J A, Garland, R B, McMackins, D E, Dayringer, H, Tóth, M V

“…The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an…”
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A Study of Price Accuracy in the New Zealand Supermarket Industry by Garland, B.R, McGuinness, D.E

“…The advent of optical scanning technology at supermarket checkouts has meant the replacement of item pricing by shelf pricing and an accompanied concern about…”
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A novel series of orally active antiplatelet agents by Zablocki, Jeffery A., Tjoeng, Foe S., Bovy, Philippe R., Miyano, Masateru, Garland, Robert B., Williams, Kenneth, Schretzman, Lori, Zupec, Mark E., Rico, Joseph G., Lindmark, Richard J., Toth, Mihaly V., McMackins, Dudley E., Adams, Steven P., Panzer-Knodle, Susan G., Nicholson, Nancy S., Taite, Beatrice B., Salyers, Anita K., King, Lucy W., Campion, James G., Feigen, Larry P.

“…A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet…”
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Studies in the synthesis of the thromboxane receptor antagonist EP 092 and its enantiomers by Garland, Robert B, Miyano, Masateru, Pireh, Daisy, Clare, Michael, Finnegan, Patricia M, Swenton, Lydia

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Evaluation of the inhibition of other metalloproteinases by matrix metalloproteinase inhibitors by Marcotte, P A, Elmore, I N, Guan, Z, Magoc, T J, Albert, D H, Morgand, D W, Curtin, M L, Garland, R B, Guo, Y, Heyman, H R, Holms, J H, Sheppard, G S, Steinman, D H, Wada, C K, Davidsen, S K

“…Two series of compounds synthesized as specific matrix metalloproteinase (MMP) inhibitors have been evaluated for their inhibition of non-MMPs. In a series of…”
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Occupying the Crease: An Exploration of Youth Cricket in New Zealand by Gaskin, C J, Garland, B R

“…Recruiting and retaining participants is a challenge that most sport administrators face. The present study examined motives for participation/discontinuation…”
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Total synthesis of 11.beta.-methyl-19-norsteroids by Garland, R. B, Palmer, J. R, Pappo, R

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Synthesis of 5-fluoroprostacyclin by Djuric, Stevan W, Garland, Robert B, Nysted, Leonard N, Pappo, Raphael, Plume, Gatis, Swenton, Lydia

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Trifluoromethyl ketones as inhibitors of histone deacetylase by Frey, Robin R., Wada, Carol K., Garland, Robert B., Curtin, Michael L., Michaelides, Michael R., Li, Junling, Pease, Lori J., Glaser, Keith B., Marcotte, Patrick A., Bouska, Jennifer J., Murphy, Shannon S., Davidsen, Steven K.

“…Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar…”
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Potent in Vitro and in Vivo Inhibitors of Platelet Aggregation Based Upon the Arg-Gly-Asp Sequence of Fibrinogen. (Aminobenzamidino)succinyl (ABAS) Series of Orally Active Fibrinogen Receptor Antagonists by Zablocki, Jeffery A, Rico, Joseph G, Garland, Robert B, Rogers, Thomas E, Williams, Kenneth, Schretzman, Lori A, Rao, Shashidhar A, Bovy, Philippe R, Tjoeng, Foe S

“…Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our i.v. antiplatelet…”
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Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC) by CURTIN, Michael L, GARLAND, Robert B, HEYMAN, H. Robin, FREY, Robin R, MICHAELIDES, Michael R, JUNLING LI, PEASE, Lori J, GLASER, Keith B, MARCOTTE, Patrick A, DAVIDSEN, Steven K

“…A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original…”
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α-Keto amides as inhibitors of histone deacetylase by Wada, Carol K., Frey, Robin R., Ji, Zhiqin, Curtin, Michael L., Garland, Robert B., Holms, James H., Li, Junling, Pease, Lori J., Guo, Jun, Glaser, Keith B., Marcotte, Patrick A., Richardson, Paul L., Murphy, Shannon S., Bouska, Jennifer J., Tapang, Paul, Magoc, Terrance J., Albert, Daniel H., Davidsen, Steven K., Michaelides, Michael R.

“…α-Keto ester and amides were found to be potent inhibitors of histone deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar…”
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A stereospecific total synthesis of the antracyclinones (±)-daunomycinone and (±)-isodaunomycinone by HANSEN, D. W. JR, PAPPO, R, GARLAND, R. B

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