Search Results - "GARIPPA, R"

The Amino Terminus of GLUT4 Functions as an Internalization Motif but Not an Intracellular Retention Signal When Substituted for the Transferrin Receptor Cytoplasmic Domain by Garippa, Ralph J., Judge, Timothy W., James, David E., McGraw, Timothy E.

“…Previous studies have demonstrated that the amino-terminal cytoplasmic domain of GLUT4 contains a phenylalanine-based targeting motif that determines its…”
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Ro 25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part I: In vitro and in vivo bronchodilator studies by O'Donnell, M, Garippa, R J, Rinaldi, N, Selig, W M, Simko, B, Renzetti, L, Tannu, S A, Wasserman, M A, Welton, A, Bolin, D R

“…Ro 25-1553, a cyclic peptide analog of vasoactive intestinal peptide (VIP), was designed to overcome many of the deficiencies inherent in this natural…”
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Structure-activity studies of vasoactive intestinal polypeptide by O'Donnell, M, Garippa, R J, O'Neill, N C, Bolin, D R, Cottrell, J M

“…This report explores the potential side-chain functional groups required for interaction of the bronchodilator neuropeptide, vasoactive intestinal peptide…”
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Ro 25-1553: a novel, long-acting vasoactive intestinal peptide agonist. Part II: Effect on in vitro and in vivo models of pulmonary anaphylaxis by O'Donnell, M, Garippa, R J, Rinaldi, N, Selig, W M, Tocker, J E, Tannu, S A, Wasserman, M A, Welton, A, Bolin, D R

“…Studies were conducted to compare the effect of native vasoactive intestinal peptide (VIP), Ro 25-1553 (a cyclic peptide analog of VIP) and salbutamol (a…”
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Transferrin Receptor Containing the SDYQRL Motif of TGN38 Causes a Reorganization of the Recycling Compartment but Is Not Targeted to the TGN by Johnson, A. O., Ghosh, R. N., Dunn, K. W., Garippa, R., Park, J., Mayor, S., Maxfield, F. R., McGraw, T. E.

“…The SDYQRL motif of the cytoplasmic domain of TGN38 is involved in targeting TGN38 from endosomes to the TGN. To create a system for studying this pathway, we…”
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The Carboxyl Terminus of GLUT4 Contains a Serine-Leucine-Leucine Sequence That Functions as a Potent Internalization Motif in Chinese Hamster Ovary Cells by Garippa, Ralph J., Johnson, Amy, Park, Juliet, Petrush, Rebecca L., McGraw, Timothy E.

“…To characterize the trafficking motifs contained in the carboxyl terminus of GLUT4, a chimera (GTCTR) was constructed in which the carboxyl-terminal 30 amino…”
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Structure-activity studies of vasoactive intestinal peptide (VIP): cyclic disulfide analogs by Bolin, D R, Cottrell, J, Garippa, R, O'Neill, N, Simko, B, O'Donnell, M

“…Analogs of vasoactive intestinal peptide with cysteine residues incorporated at selected sites within the sequence were prepared by solid phase methods,…”
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Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity by Guertin, Kevin R., Setti, Lina, Qi, Lida, Dunsdon, Rachel M., Dymock, Brian W., Jones, Philip S., Overton, Hilary, Taylor, Mathew, Williams, Glyn, Sergi, Joseph A., Wang, Karen, Peng, Ying, Renzetti, Marcia, Boyce, Rogely, Falcioni, Fiorenza, Garippa, Ralph, Olivier, Andrée R.

“…A novel series of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents have been identified. These compounds show non-selective…”
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Pharmacological profile of Ro 23-3544, a new aerosol active leukotriene receptor antagonist by O'Donnell, M, Welton, A F, Crowley, H, Brown, D, Garippa, R, Cohen, N, Weber, G, Banner, B, Lopresti, R J

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A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the ion works HTTM system by Guthrie, Heather, Livingston, Frederick S, Gubler, Ueli, Garippa, Ralph

“…Several commercially available pharmaceutical compounds have been shown to block the IKr current of the cardiac action potential. This effect can cause a…”
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Relaxant activity of atriopeptins in isolated guinea pig airway and vascular smooth muscle by O'Donnell, M, Garippa, R, Welton, A F

“…Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the…”
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3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists by Cohen, Noal, Weber, Giuseppe, Banner, Bruce L, Lopresti, Rocco J, Schaer, Beatrice, Focella, Antonino, Zenchoff, Gladys B, Chiu, Anne Marie, Todaro, Louis

“…Evaluation of a series of 3,4-dihydro-2H-1-benzopyran-2-carboxylic acids linked to the 2-hydroxyacetophenone pharmacophore present in the standard…”
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Comparison of cyclic and linear analogs of vasoactive intestinal peptide by Bolin, D R, Cottrell, J, Garippa, R, Rinaldi, N, Senda, R, Simko, B, O'Donnell, M

“…A series of i-->i + 4 side-chain to side-chain lactam analogs of vasoactive intestinal peptide has been prepared in order to study the effect of cyclization on…”
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Structure-activity studies on the vasoactive intestinal peptide pharmacophore. 1. Analogs of tyrosine by Bolin, D R, Cottrell, J, Garippa, R, Michalewsky, J, Rinaldi, N, Simko, B, O'Donnell, M

“…From previous work, the primary functional groups, i.e. side chains, of the vasoactive intestinal peptide which are responsible for interaction with the VIP…”
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Degradation of vasoactive intestinal peptide in bronchial alveolar lavage fluid by BOLIN, D. R, COTTRELL, J, MICHALEWSKY, J, GARIPPA, R, O'NEILL, N, SIMKO, B, O'DONNELL, M

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Mechanisms of methacholine-induced coronary vasospasm in an experimental model of variant angina in the anesthetized rat by Vergona, R A, Herrott, C, Garippa, R, Hirkaler, G

“…Methacholine (Mch), when injected near the ostia of the coronary arteries, induces an intense coronary vasospasm which can be measured by the degree of S wave…”
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