Search Results - "GARDAI, Shyra J"

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte by Gardai, Shyra J., McPhillips, Kathleen A., Frasch, S. Courtney, Janssen, William J., Starefeldt, Anna, Murphy-Ullrich, Joanne E., Bratton, Donna L., Oldenborg, Per-Arne, Michalak, Marek, Henson, Peter M.

“…Apoptotic-cell removal is critical for development, tissue homeostasis, and resolution of inflammation. Although many candidate systems exist, only…”
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Recognition ligands on apoptotic cells: a perspective by Gardai, Shyra J., Bratton, Donna L., Ogden, Carole Anne, Henson, Peter M.

“…The process of apoptosis includes critically important changes on the cell surface that lead to its recognition and removal. The recognition also generates a…”
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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms by Riley, Brigit E, Gardai, Shyra J, Emig-Agius, Dorothea, Bessarabova, Marina, Ivliev, Alexander E, Schüle, Birgitt, Schüle, Birgit, Alexander, Jeff, Wallace, William, Halliday, Glenda M, Langston, J William, Braxton, Scott, Yednock, Ted, Shaler, Thomas, Johnston, Jennifer A

“…Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum, and cortex…”
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Nonfucosylation of an anti-TIGIT antibody enhances FcγR engagement, driving innate immune activation and antitumor activity by Smith, Alyson J, Thurman, Robert E, Zeng, Weiping, Grogan, Bryan, Lucas, Sasha, Gutierrez, Guadalupe, Heiser, Ryan A, Wo, Serena W, Blackmarr, Amber, Peterson, Scott, Gardai, Shyra J

“…TIGIT is an immune checkpoint receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells, and natural killer (NK) cells. TIGIT…”
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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease by Gardai, Shyra J, Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P, Schenk, Dale B, Bard, Frederique, Langston, J William, Yednock, Ted, Johnston, Jennifer A

“…Alpha-synuclein protein is strongly implicated in the pathogenesis Parkinson's disease. Increased expression of α-synuclein due to genetic multiplication or…”
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ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages by Jehle, Andreas W, Gardai, Shyra J, Li, Suzhao, Linsel-Nitschke, Patrick, Morimoto, Konosuke, Janssen, William J, Vandivier, R. William, Wang, Nan, Greenberg, Steven, Dale, Benjamin M, Qin, Chunbo, Henson, Peter M, Tall, Alan R

“…The mammalian ATP-binding cassette transporters A1 and A7 (ABCA1 and -A7) show sequence similarity to CED-7, a Caenorhabditis elegans gene that mediates the…”
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SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models by Gray, Elizabeth, Ulrich, Michelle, Epp, Angela, Younan, Patrick, Sahetya, Disha, Hensley, Kelly, Allred, Sean, Huang, Li-Ya, Hahn, Julie, Gahnberg, Kristen, Treuting, Piper M, Trueblood, Esther S, Gosink, John J, Thurman, Robert, Wo, Serena, Spahr, Kellie, Haass, Evgenia Jane, Snead, Katie, Miller, Dannah, Padilla, Mary, Smith, Alyson J, Frantz, Chris, Schrum, Jason P, Nazarenko, Natalya, Gardai, Shyra J

“…BackgroundSGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the…”
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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth by Ameshima, Shingo, Golpon, Heiko, Cool, Carlyne D, Chan, Daniel, Vandivier, R William, Gardai, Shyra J, Wick, Marilee, Nemenoff, Raphael A, Geraci, Mark W, Voelkel, Norbert F

“…ABSTRACT—PPARγ is a member of a family of nuclear receptors/ligand–dependent transcription factors, which bind to hormone response elements on target gene…”
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Oxidants Inhibit ERK/MAPK and Prevent Its Ability to Delay Neutrophil Apoptosis Downstream of Mitochondrial Changes and at the Level of XIAP by Gardai, Shyra J, Whitlock, Ben B, Xiao, Yi Qun, Bratton, Donna B, Henson, Peter M

“…Normal spontaneous apoptosis in neutrophils is enhanced by “stress” stimuli such as tumor necrosis factor-α, Fas ligand, and oxidants, and this effect is…”
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Brentuximab Vedotin-Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity by Heiser, Ryan A, Cao, Anthony T, Zeng, Weiping, Ulrich, Michelle, Younan, Patrick, Anderson, Martha E, Trueblood, Esther S, Jonas, Mechthild, Thurman, Robert, Law, Che-Leung, Gardai, Shyra J

“…Brentuximab vedotin, a CD30-directed antibody-drug conjugate (ADC), is approved for clinical use in multiple CD30-expressing lymphomas. The cytotoxic payload…”
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Targeting the Intrinsically Disordered Structural Ensemble of [alpha]-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson's Disease by Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P. J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa

“…The misfolding of intrinsically disordered proteins such as [alpha]-synuclein, tau and the A[beta] peptide has been associated with many highly debilitating…”
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Apoptotic Cells, through Transforming Growth Factor-β, Coordinately Induce Anti-inflammatory and Suppress Pro-inflammatory Eicosanoid and NO Synthesis in Murine Macrophages by Freire-de-Lima, Celio G., Xiao, Yi Qun, Gardai, Shyra J., Bratton, Donna L., Schiemann, William P., Henson, Peter M.

“…Apoptotic cells are rapidly engulfed by adjacent tissue cells or macrophages before they can release pro-inflammatory/proimmunogenic intracellular contents. In…”
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Reversible Chemical Modification of Antibody Effector Function Mitigates Unwanted Systemic Immune Activation by Moquist, Philip N., Zhang, Xinqun, Leiske, Chris I., Eng-Duncan, Nicole M.-L., Zeng, Weiping, Bindman, Noah A., Wo, Serena W., Wong, Abbie, Henderson, Clark M., Crowder, Karalyne, Lyon, Robert, Doronina, Svetlana O., Senter, Peter D., Neff-LaFord, Haley D., Sussman, Django, Gardai, Shyra J., Levengood, Matthew R.

“…Antibody effector functions including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) are mediated through the interaction of the…”
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Therapeutic and Prophylactic Antitumor Activity of an Oral Inhibitor of Fucosylation in Spontaneous Mammary Cancers by Disis, Mary L, Corulli, Lauren R, Gad, Ekram A, Koehnlein, Marlese R, Cecil, Denise L, Senter, Peter D, Gardai, Shyra J, Okeley, Nicole M

“…2-fluorofucose (2FF) inhibits protein and cellular fucosylation. Afucosylation of IgG antibodies enhances antibody-dependent cell-mediated cytotoxicity by…”
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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease by Tóth, Gergely, Gardai, Shyra J, Zago, Wagner, Bertoncini, Carlos W, Cremades, Nunilo, Roy, Susan L, Tambe, Mitali A, Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steven, Bova, Michael, Regnstrom, Karin, Chiou, San-San, Johnston, Jennifer, Callaway, Kari, Anderson, John P, Jobling, Michael F, Buell, Alexander K, Yednock, Ted A, Knowles, Tuomas P J, Vendruscolo, Michele, Christodoulou, John, Dobson, Christopher M, Schenk, Dale, McConlogue, Lisa

“…The misfolding of intrinsically disordered proteins such as α-synuclein, tau and the Aβ peptide has been associated with many highly debilitating…”
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Abstract 4914: Auristatin-based antibody drug conjugates activate multiple ER stress response pathways resulting in immunogenic cell death and amplified T-cell responses by Cao, Anthony, Heiser, Ryan, Law, Che-Leung, Gardai, Shyra J.

“…Brentuximab vedotin (ADCETRIS®) is an antibody-drug conjugate (ADC) directed against CD30. This ADC consists of monoclonal antibodies conjugated to the…”
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Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα by JANSSEN, William J, MCPHILLIPS, Kathleen A, DICKINSON, Matthew G, LINDERMAN, Derek J, MORIMOTO, Konosuke, YI QUN XIAO, OLDHAM, Kelly M, VANDIVIER, R. William, HENSON, Peter M, GARDAI, Shyra J

“…Efficient removal of apoptotic cells is essential for the resolution of acute pulmonary inflammation. Alveolar macrophages ingest apoptotic cells less avidly…”
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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific by Zago, Wagner, Buttini, Manuel, Comery, Thomas A, Nishioka, Christopher, Gardai, Shyra J, Seubert, Peter, Games, Dora, Bard, Frédérique, Schenk, Dale, Kinney, Gene G

“…Several anti-amyloid β (Aβ) antibodies are under evaluation for the treatment of Alzheimer's disease (AD). Clinical studies using the N-terminal-directed…”
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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions by Tóth, Gergely, Neumann, Thomas, Berthet, Amandine, Masliah, Eliezer, Spencer, Brian, Tao, Jiahui, Jobling, Michael F., Gardai, Shyra J., Bertoncini, Carlos W., Cremades, Nunilo, Bova, Michael, Ballaron, Stephen, Chen, Xiao-Hua, Mao, Wenxian, Nguyen, Phuong, Tabios, Mariano C., Tambe, Mitali A., Rochet, Jean-Christophe, Junker, Hans-Dieter, Schwizer, Daniel, Sekul, Renate, Ott, Inge, Anderson, John P., Szoke, Balazs, Hoffman, Wherly, Christodoulou, John, Yednock, Ted, Agard, David A., Schenk, Dale, McConlogue, Lisa

“…The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and pathology of Parkinson’s disease. Native monomeric αSyn exists in an…”
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Abstract 4994: SEA-CD40: from bench to bedside by Gardai, Shyra J., Neff-LaFord, Haley, Epp, Angela, Yang, Jing, Manley, Thomas, Law, Che-Leung

“…SEA-CD40 is a non-fucosylated, humanized IgG1 monoclonal antibody directed against human CD40, a co-stimulatory receptor of the TNF receptor superfamily. The…”
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