Search Results - "GARCIA GRAVALOS, D"

Bioactive humulene derivatives from Asteriscus vogelii by Rauter, Amélia P, Branco, Isabel, Bermejo, Jaime, González, Antonio G, Garcı́a-Grávalos, Maria D, Feliciano, Arturo San

“…The bioactive fractions obtained from the extract of Asteriscus vogelii afforded a new humulene derivative, the 8-oxo-6,7,9,10-tetrahydrohumulen-1,12-olide (…”
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Sodwanones G, H, and I, New Cytotoxic Triterpenes from a Marine Sponge by Rudi, Amira, Goldberg, Israel, Stein, Zafra, Kashman, Yoel, Benayahu, Yehuda, Schleyer, Michael, Gravalos, M. D. Garcia

“…Three cytotoxic triterpenes, sodwanones G [5], H [6], and I [7], have been isolated from a marine sponge. The three structures were determined by…”
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New antineoplastic prenylhydroquinones. Synthesis and evaluation by MOLINARI, A, OLIVA, A, AGUILERA, A. N, MIGUEL DEL CORRAL, J. M, CASTRO, M. A, GORDALIZA, M, GARCIA-GRAVALOS, D, SAN FELICIANO, A

“…Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their…”
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Synthesis and antitumour activity of fluorinated 1-aza and 1,8-diazaanthraquinones by Ramos, M T, Díaz-Guerra, L M, García-Copín, S, Avendaño, C, García-Grávalos, D, García de Quesada, T

“…A series of 3-fluoro-1-aza- and 1,8-diazaanthraquinones, structurally related to the antitumour antibiotic diazaquinomycin A, have been prepared by Diels-Alder…”
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Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15 by GARCIA-ROCHA, M, GARCIA-GRAVALOS, M. D, AVILA, J

“…The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in…”
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PM-94128, a new isocoumarin antitumor agent produced by a marine bacterium by Cañedo, L M, Fernández Puentes, J L, Pérez Baz, J, Acebal, C, de la Calle, F, García Grávalos, D, García de Quesada, T

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Polyaromatic alkaloids from marine invertebrates as cytotoxic compounds and inhibitors of multidrug resistance caused by P-glycoprotein by QUESADA, A. R, GARCIA GRAVALOS, M. D, FERNANDEZ PUENTES, J. L

“…The effects of several members of the family of lamellarins, polyaromatic alkaloids isolated from tunicates belonging to the genus Didemnum, on the growth of…”
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Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues by Tardy, Christelle, Facompré, Michaël, Laine, William, Baldeyrou, Brigitte, Garcı́a-Gravalos, Dolores, Francesch, Andrés, Mateo, Cristina, Pastor, Alfredo, Jiménez, José A, Manzanares, Ignacio, Cuevas, Carmen, Bailly, Christian

“…The marine alkaloid lamellarin D (LAM-D) has been recently characterized as a potent poison of human topoisomerase I endowed with remarkable cytotoxic…”
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New Selective Cytotoxic Diterpenylquinones and Diterpenylhydroquinones by Miguel del Corral, José Ma, Gordaliza, Marina, Castro, Ma Angeles, Mahiques, Ma Mar, Chamorro, Pablo, Molinari, Aurora, García-Grávalos, Ma Dolores, Broughton, Howard B, San Feliciano, Arturo

“…A new series of diterpenylquinone/hydroquinones has been prepared by Diels−Alder cycloaddition between three labdanic diterpenoids (myrceocommunic acid, methyl…”
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Further antineoplastic terpenylquinones and terpenylhydroquinones by Miguel del Corral, JoséM., Gordaliza, Marina, Angeles Castro, M., Mahiques, M.Mar, San Feliciano, Arturo, García-Grávalos, M.Dolores

“…Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of…”
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Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring by Castro, Angeles, del Corral, José M.Miguel, Gordaliza, Marina, Grande, Concepción, Gómez-Zurita, Antonia, Garcı́a-Grávalos, Dolores, San Feliciano, Arturo

“…Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been…”
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A comparison between two brine shrimp assays to detect in vitro cytotoxicity in marine natural products by Carballo, José Luis, Hernández-Inda, Zaira L, Pérez, Pilar, García-Grávalos, María D

“…The brine shrimp lethality assay is considered a useful tool for preliminary assessment of toxicity. It has also been suggested for screening pharmacological…”
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Synthesis and antineoplastic activity of combretastatin analogues: Heterocombretastatins by Medarde, Manuel, Ramos, Angel, Caballero, Esther, Clairac, Rafael Peláez-Lamamié de, López, Jose Luis, Grávalos, Dolores García, Feliciano, Arturo San

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Antineoplastic and antiviral activities of podophyllotoxin related lignans by Gordaliza, M, Castro, M A, García-Grávalos, M D, Ruiz, P, Miguel del Corral, J M, San Feliciano, A

“…28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to…”
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Synthesis and antineoplastic activity of cyclolignan aldehydes by Gordaliza, Marina, Castro, M a Angeles, Miguel del Corral, José M a, López-Vázquez, M a Luisa, A. García, Pablo, García-Grávalos, M a Dolores, San Feliciano, Arturo

“…Several aldehydes related to methyl 9-deoxy-9-oxo-α-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared…”
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4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain by Hernández, L M, Blanco, J A, Baz, J P, Puentes, J L, Millán, F R, Vázquez, F E, Fernández-Chimeno, R I, Grávalos, D G

“…Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine…”
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Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa by CHAVEZ, H, RODRIGUEZ, G, ESTEVEZ-BRAUN, A, RAVELO, A. G, ESTEVEZ-REYES, R, GONZALEZ, A. G, FDEZ-PUENTE, J. L, GARCIA-GRAVALOS, D

“…Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established…”
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Structure-activity relationships of the didemnins1,2 by SAKAI, R, RINEHART, K. L, GARCIA GRAVALOS, D, GARCIA DE QUESADA, T, WILSON, G. R, HEID, R. M, KISHORE, V, KUNDU, B, FAIRCLOTH, G, GLOER, J. B, CARNEY, J. R, NAMIKOSHI, M, SUN, F, HUGHES, R. G

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Antineoplastic and antiviral activities of some cyclolignans by San Feliciano, A, Gordaliza, M, Miguel del Corral, J M, Castro, M A, García-Grávalos, M D, Ruiz-Lázaro, P

“…Nineteen cyclolignans of varied structures, most of them isolated from Juniperus sabina leaves, were evaluated for their antineoplastic and antiviral…”
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Two new antitumoral polyether squalene derivatives by Norte, Manuel, Fernández, JoséJ., Souto, María L., García-Grávalos, María D.

“…Two new polyether squalene derivatives isodehydrothyrsiferol 2 and 10-epidehydrothyrsiferol 3 have been isolated from the red alga Laurencia viridis. Their…”
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