Search Results - "GARBAY, Serge"

Stat3 Controls Tubulointerstitial Communication during CKD by Bienaimé, Frank, Muorah, Mordi, Yammine, Lucie, Burtin, Martine, Nguyen, Clément, Baron, Willian, Garbay, Serge, Viau, Amandine, Broueilh, Mélanie, Blanc, Thomas, Peters, Dorien, Poli, Valeria, Anglicheau, Dany, Friedlander, Gérard, Pontoglio, Marco, Gallazzini, Morgan, Terzi, Fabiola

“…In CKD, tubular cells may be involved in the induction of interstitial fibrosis, which in turn, leads to loss of renal function. However, the molecular…”
Get full text

Human mutations affect the epigenetic/bookmarking function of HNF1B by Lerner, Jonathan, Bagattin, Alessia, Verdeguer, Francisco, Makinistoglu, Munevver P, Garbay, Serge, Felix, Tristan, Heidet, Laurence, Pontoglio, Marco

“…Bookmarking factors are transcriptional regulators involved in the mitotic transmission of epigenetic information via their ability to remain associated with…”
Get full text

A mitotic transcriptional switch in polycystic kidney disease by Pontoglio, Marco, Le Corre, Stephanie, Callens, Celine, Terzi, Fabiola, Igarashi, Peter, Fischer, Evelyne, Doyen, Antonia, Verdeguer, Francisco, Garbay, Serge

“…Deficiency of the transcription factor HNF-1β results in kidney cyst formation. Marco Pontoglio and his colleagues now show that HNF-1β normally remains bound…”
Get full text

MITF - A controls branching morphogenesis and nephron endowment by Phelep, Aurélie, Laouari, Denise, Bharti, Kapil, Burtin, Martine, Tammaccaro, Salvina, Garbay, Serge, Nguyen, Clément, Vasseur, Florence, Blanc, Thomas, Berissi, Sophie, Langa-Vives, Francina, Fischer, Evelyne, Druilhe, Anne, Arnheiter, Heinz, Friedlander, Gerard, Pontoglio, Marco, Terzi, Fabiola

“…Congenital nephron number varies widely in the human population and individuals with low nephron number are at risk of developing hypertension and chronic…”
Get full text

A transcriptional network in polycystic kidney disease by Gresh, Lionel, Fischer, Evelyne, Reimann, Andreas, Tanguy, Myriam, Garbay, Serge, Shao, Xinli, Hiesberger, Thomas, Fiette, Laurence, Igarashi, Peter, Yaniv, Moshe, Pontoglio, Marco

“…Mutations in cystic kidney disease genes represent a major genetic cause of end‐stage renal disease. However, the molecular cascades controlling the expression…”
Get full text

Genome-Wide Discovery of Functional Transcription Factor Binding Sites by Comparative Genomics: The Case of Stat3 by Vallania, Francesco, Schiavone, Davide, Dewilde, Sarah, Pupo, Emanuela, Garbay, Serge, Calogero, Raffaele, Pontoglio, Marco, Provero, Paolo, Poli, Valeria, Darnell, James E.

“…The identification of direct targets of transcription factors is a key problem in the study of gene regulatory networks. However, the use of high throughput…”
Get full text

A suppressor locus for MODY3-diabetes by Garcia-Gonzalez, Miguel A., Carette, Claire, Bagattin, Alessia, Chiral, Magali, Makinistoglu, Munevver Parla, Garbay, Serge, Prévost, Géraldine, Madaras, Cécile, Hérault, Yann, Leibovici, Michel, Pontoglio, Marco

“…Maturity Onset Diabetes of the Young type 3 (MODY3), linked to mutations in the transcription factor HNF1A, is the most prevalent form of monogenic diabetes…”
Get full text

A specific molecular signature in SARS-CoV-2-infected kidney biopsies by Isnard, Pierre, Vergnaud, Paul, Garbay, Serge, Jamme, Matthieu, Eloudzeri, Maeva, Karras, Alexandre, Anglicheau, Dany, Galantine, Valérie, Jalal Eddine, Arwa, Gosset, Clément, Pourcine, Franck, Zarhrate, Mohammed, Gibier, Jean-Baptiste, Rensen, Elena, Pietropaoli, Stefano, Barba-Spaeth, Giovanna, Duong-Van-Huyen, Jean-Paul, Molina, Thierry J, Mueller, Florian, Zimmer, Christophe, Pontoglio, Marco, Terzi, Fabiola, Rabant, Marion

“…Acute kidney injury is one of the most important complications in patients with COVID-19 and is considered a negative prognostic factor with respect to patient…”
Get full text

A genomic map of p53 binding sites identifies novel p53 targets involved in an apoptotic network by MILED, Chaouki, PONTOGLIO, Marco, GARBAY, Serge, YANIV, Moshe, WEITZMAN, Jonathan B

“…The transcriptional activity of the p53 protein is central to its role in tumor suppression. Identification of the complete repertoire of p53-regulated genes…”
Get full text

The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation by Gresh, Lionel, Bourachot, Brigitte, Reimann, Andreas, Guigas, Bruno, Fiette, Laurence, Garbay, Serge, Muchardt, Christian, Hue, Louis, Pontoglio, Marco, Yaniv, Moshe, Klochendler-Yeivin, Agnès

“…Regulation of gene expression underlies cell differentiation and organogenesis. Both transcription factors and chromatin modifiers are crucial for this…”
Get full text

Papillomavirus E2 induces p53-independent apoptosis in HeLa cells by DESAINTES, C, GOYAT, S, GARBAY, S, YANIV, M, THIERRY, F

“…We have previously shown that expression of the papillomavirus E2 protein in HeLa cells induces p53 accumulation and causes both cell cycle arrest and…”
Get full text

HNF1β bookmarking involves Topoisomerase 1 activation and DNA topology relaxation in mitotic chromatin by Bagattin, Alessia, Tammaccaro, Salvina Laura, Chiral, Magali, Makinistoglu, Munevver Parla, Zimmermann, Nicolas, Lerner, Jonathan, Garbay, Serge, Kuperwasser, Nicolas, Pontoglio, Marco

“…HNF1β (HNF1B) is a transcription factor frequently mutated in patients with developmental renal disease. It binds to mitotic chromatin and reactivates gene…”
Get full text

Hepatocyte nuclear factor 1β controls nephron tubular development by Massa, Filippo, Garbay, Serge, Bouvier, Raymonde, Sugitani, Yoshinobu, Noda, Tetsuo, Gubler, Marie-Claire, Heidet, Laurence, Pontoglio, Marco, Fischer, Evelyne

“…Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures…”
Get full text

5399 VONAFEXOR AS A NOVEL THERAPY FOR CHRONIC KIDNEY DISEASE by Yang, Jiufang, Vasseur, Florence, Burtin, Martine, Nguyen, Clement, Pelosi, Michele, Garbay, Serge, Mallinjoud, Pierre, De Chassey, Benoit, Vonderscher, Jacky, Dartell, Raphael, Pontoglio, Marco, Terzi, Fabiola

Get full text

Hepatocyte nuclear factor 1α and β control terminal differentiation and cell fate commitment in the gut epithelium by D'Angelo, Anna, Bluteau, Olivier, Garcia-Gonzalez, Miguel A., Gresh, Lionel, Doyen, Antonia, Garbay, Serge, Robine, Sylvie, Pontoglio, Marco

“…The intestinal epithelium is a complex system characterized by massive and continuous cell renewal and differentiation. In this context, cell-type-specific…”
Get full text

Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease by Fiorentino, Arianna, Christophorou, Armelle, Massa, Filippo, Garbay, Serge, Chiral, Magali, Ramsing, Mette, Rasmussen, Maria, Gubler, Marie-Claire, Bessieres, Bettina, Heidet, Laurence, Fischer, Evelyne, Pontoglio, Marco

“…The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial…”
Get full text

Developmental Renal Glomerular Defects at the Origin of Glomerulocystic Disease by Fiorentino, Arianna, Christophorou, Armelle, Massa, Filippo, Garbay, Serge, Chiral, Magali, Ramsing, Mette, Rasmussen, Maria, Gubler, Marie-Claire, Bessieres, Bettina, Heidet, Laurence, Fischer, Evelyne, Pontoglio, Marco

“…Highlights d Renal glomerulogenesis implies the separation of vascular and urinary poles (VP/UP) d Pole separation is due to a protuberance whose emergence is…”
Get full text

Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule by Terryn, Sara, Tanaka, Karo, Lengelé, Jean-Philippe, Olinger, Eric, Dubois-Laforgue, Danièle, Garbay, Serge, Kozyraki, Renata, Van Der Smissen, Patrick, Christensen, Erik I, Courtoy, Pierre J, Bellanné-Chantelot, Christine, Timsit, José, Pontoglio, Marco, Devuyst, Olivier

“…Hepatocyte nuclear factor 1α (HNF1α) is a transcription factor expressed in the liver, pancreas, and proximal tubule of the kidney. Mutations of HNF1α cause an…”
Get more information

SO056NOVEL MECHANISM OF GLOMERULAR CYST FORMATION IN HNF1B DEFICIENCY by Fiorentino, Arianna, Grevellec, Armelle, Massa, Filippo, Garbay, Serge, Fischer, Evelyne, Pontoglio, Marco

Get full text

The transcription factor HNF1α regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule by Tanaka, Karo, Terryn, Sara, Geffers, Lars, Garbay, Serge, Pontoglio, Marco, Devuyst, Olivier

“…The Cl(-)/H(+) exchanger ClC-5 is essential for the endocytic activity of the proximal tubule cells and the tubular clearance of proteins filtered in the…”
Get more information