Search Results - "GAO, Geli"

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia by González-Juarbe, Norberto, Gilley, Ryan Paul, Hinojosa, Cecilia Anahí, Bradley, Kelley Margaret, Kamei, Akinobu, Gao, Geli, Dube, Peter Herman, Bergman, Molly Ann, Orihuela, Carlos Javier

“…Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL. We report that…”
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Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium by Kietzman, Colin C., Gao, Geli, Mann, Beth, Myers, Lance, Tuomanen, Elaine I.

“…Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes…”
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Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae by Rosch, Jason W, Gao, Geli, Ridout, Granger, Wang, Yong-Dong, Tuomanen, Elaine I

“…The ability of bacteria to sense and respond to both environmental and intracellular metal concentrations plays an important role in pathogenesis. The…”
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Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid—CbpA Peptide Recombinant Fusion Protein by Mann, Beth, Thornton, Justin, Heath, Richard, Wade, Kristin R., Tweten, Rodney K., Gao, Geli, Kasmi, Karim El, Jordan, John B., Mitrea, Diana M., Kriwacki, Richard, Maisonneuve, Jeff, Alderson, Mark, Tuomanen, Elaine I.

“…Background. Pneumococcus, meningococcus, and Haemophilus influenzas cause a similar spectrum of infections in the ear, lung, blood, and brain. They share…”
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Dissecting Bacterial Cell Wall Entry and Signaling in Eukaryotic Cells: an Actin-Dependent Pathway Parallels Platelet-Activating Factor Receptor-Mediated Endocytosis by Loh, Lip Nam, Gao, Geli, Tuomanen, Elaine I

“…The Gram-positive bacterial cell wall (CW) peptidoglycan-teichoic acid complex is released into the host environment during bacterial metabolism or death. It…”
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Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex by Mann, Beth, Crawford, Jeremy Chase, Reddy, Kavya, Lott, Josi, Youn, Yong Ha, Gao, Geli, Guy, Cliff, Chou, Ching-Heng, Darnell, Daniel, Trivedi, Sanchit, Bomme, Perrine, Loughran, Allister J, Thomas, Paul G, Han, Young-Goo, Tuomanen, Elaine I

“…Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that…”
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Tissue-Specific Contributions of Pneumococcal Virulence Factors to Pathogenesis by Orihuela, Carlos J., Gao, Geli, Francis, Kevin P., Yu, Jun, Tuomanen, Elaine I.

“…We assessed the ability of Streptococcus pneumoniae mutants deficient in either choline binding protein A (CbpA), pneumolysin (Pln), pyruvate oxidase (SpxB),…”
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A Perfect Storm: Increased Colonization and Failure of Vaccination Leads to Severe Secondary Bacterial Infection in Influenza Virus-Infected Obese Mice by Karlsson, Erik A, Meliopoulos, Victoria A, van de Velde, Nicholas C, van de Velde, Lee-Ann, Mann, Beth, Gao, Geli, Rosch, Jason, Tuomanen, Elaine, McCullers, Jon, Vogel, Peter, Schultz-Cherry, Stacey

“…Obesity is a risk factor for developing severe disease following influenza virus infection; however, the comorbidity of obesity and secondary bacterial…”
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Calcium efflux is essential for bacterial survival in the eukaryotic host by Rosch, Jason W, Sublett, Jack, Gao, Geli, Wang, Yong-Dong, Tuomanen, Elaine I

“…In dynamic environments, intracellular homeostasis is maintained by transport systems found in all cells. While bacterial influx systems for essential trace…”
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Microarray Analysis of Pneumococcal Gene Expression during Invasive Disease by ORIHUELA, Carlos J, RADIN, Jana N, SUBLETT, Jack E, GAO, Geli, KAUSHAL, Deepak, TUOMANEN, Elaine I

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin by Lebensburger, Jeffrey D., Howard, Thad, Hu, Yunming, Pestina, Tamara I., Gao, Geli, Johnson, Melissa, Zakharenko, Stanislav S., Ware, Russell E., Tuomanen, Elaine I., Persons, Derek A., Rosch, Jason W.

“…Sickle cell anemia is characterized by chronic hemolysis coupled with extensive vascular inflammation. This inflammatory state also mechanistically promotes a…”
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A live‐attenuated pneumococcal vaccine elicits CD4+ T‐cell dependent class switching and provides serotype independent protection against acute otitis media by Rosch, Jason W, Iverson, Amy R, Humann, Jessica, Mann, Beth, Gao, Geli, Vogel, Peter, Mina, Michael, Murrah, Kyle A, Perez, Antonia C, Edward Swords, W, Tuomanen, Elaine I, McCullers, Jonathan A

“…Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A…”
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Hypersusceptibility to Invasive Pneumococcal Infection in Experimental Sickle Cell Disease Involves Platelet-Activating Factor Receptor by Miller, Martha L., Gao, Geli, Pestina, Tamara, Persons, Derek, Tuomanen, Elaine

“…Children with sickle cell disease have a 600-fold increased incidence of invasive pneumococcal disease. Platelet-activating factor receptor (PAFr) mediates…”
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Preparation of Purified Gram-positive Bacterial Cell Wall and Detection in Placenta and Fetal Tissues by Mann, Beth, Loh, Lip Nam, Gao, Geli, Tuomanen, Elaine

“…Cell wall is a complex biopolymer on the surface of all Gram-positive bacteria. During infection, cell wall is recognized by the innate immune receptor…”
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Cell Wall-Mediated Neuronal Damage in Early Sepsis by Orihuela, Carlos J, Fillon, Sophie, Smith-Sielicki, S. Hope, El Kasmi, Karim C, Gao, Geli, Soulis, Konstantinos, Patil, Avinash, Murray, Peter J, Tuomanen, Elaine I

“…Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within…”
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Pneumolysin, a Protein Toxin of Streptococcus pneumoniae, Induces Nitric Oxide Production from Macrophages by BRAUN, J. S, NOVAK, R, GAO, G, MURRAY, P. J, SHENEP, J. L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cephalosporin-resistant pneumococci and sickle cell disease by Miller, Martha L, Obert, Caroline A, Gao, Geli, Daw, Najat C, Flynn, Patricia, Tuomanen, Elaine

“…Sickle cell anemia patients have 600 times the risk for invasive pneumococcal disease than their healthy peers. High-level cephalosporin resistance was…”
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Pneumococcal neuraminidase activates TGF-β signalling by Gratz, Nina, Loh, Lip Nam, Mann, Beth, Gao, Geli, Carter, Robert, Rosch, Jason, Tuomanen, Elaine I

“…Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates. We noted…”
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Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function by Brown, Armand O, Mann, Beth, Gao, Geli, Hankins, Jane S, Humann, Jessica, Giardina, Jonathan, Faverio, Paola, Restrepo, Marcos I, Halade, Ganesh V, Mortensen, Eric M, Lindsey, Merry L, Hanes, Martha, Happel, Kyle I, Nelson, Steve, Bagby, Gregory J, Lorent, Jose A, Cardinal, Pablo, Granados, Rosario, Esteban, Andres, LeSaux, Claude J, Tuomanen, Elaine I, Orihuela, Carlos J

“…Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily…”
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Exogenous remodeling of lung resident macrophages protects against infectious consequences of bone marrow-suppressive chemotherapy by Kamei, Akinobu, Gao, Geli, Neale, Geoffrey, Loh, Lip Nam, Vogel, Peter, Thomas, Paul G., Tuomanen, Elaine I., Murray, Peter J.

“…Infection is the single greatest threat to survival during cancer chemotherapy because of depletion of bone marrow-derived immune cells. Phagocytes, especially…”
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