Search Results - "GANDHI, Sonia"

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases by Choi, Minee L., Gandhi, Sonia

“…Misfolding and aggregation of the proteins amyloid‐β, tau and alpha‐synuclein is the predominant pathology underlying the neurodegenerative disorders,…”
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Mechanism of Oxidative Stress in Neurodegeneration by Gandhi, Sonia, Abramov, Andrey Y.

“…Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may…”
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Radiation-induced inflammatory cascade and its reverberating crosstalks as potential cause of post-radiotherapy second malignancies by Gandhi, Sonia, Chandna, Sudhir

“…The disease-free survival following radiotherapy is often limited by the development of second/secondary cancers. This significant impediment to effective…”
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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans by Ng, Kevin W, Faulkner, Nikhil, Cornish, Georgina H, Rosa, Annachiara, Harvey, Ruth, Hussain, Saira, Ulferts, Rachel, Earl, Christopher, Wrobel, Antoni G, Benton, Donald J, Roustan, Chloe, Bolland, William, Thompson, Rachael, Agua-Doce, Ana, Hobson, Philip, Heaney, Judith, Rickman, Hannah, Paraskevopoulou, Stavroula, Houlihan, Catherine F, Thomson, Kirsty, Sanchez, Emilie, Shin, Gee Yen, Spyer, Moira J, Joshi, Dhira, O'Reilly, Nicola, Walker, Philip A, Kjaer, Svend, Riddell, Andrew, Moore, Catherine, Jebson, Bethany R, Wilkinson, Meredyth, Marshall, Lucy R, Rosser, Elizabeth C, Radziszewska, Anna, Peckham, Hannah, Ciurtin, Coziana, Wedderburn, Lucy R, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Stockinger, Brigitta, McCauley, John, Gamblin, Steve J, McCoy, Laura E, Cherepanov, Peter, Nastouli, Eleni, Kassiotis, George

“…Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins,…”
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α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease by Ludtmann, Marthe H. R., Angelova, Plamena R., Horrocks, Mathew H., Choi, Minee L., Rodrigues, Margarida, Baev, Artyom Y., Berezhnov, Alexey V., Yao, Zhi, Little, Daniel, Banushi, Blerida, Al-Menhali, Afnan Saleh, Ranasinghe, Rohan T., Whiten, Daniel R., Yapom, Ratsuda, Dolt, Karamjit Singh, Devine, Michael J., Gissen, Paul, Kunath, Tilo, Jaganjac, Morana, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation causes α-synuclein to switch from its physiological role to a pathological toxic gain of function. Under physiological conditions,…”
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation by Angelova, Plamena R., Choi, Minee L., Berezhnov, Alexey V., Horrocks, Mathew H., Hughes, Craig D., De, Suman, Rodrigues, Margarida, Yapom, Ratsuda, Little, Daniel, Dolt, Karamjit S., Kunath, Tilo, Devine, Michael J., Gissen, Paul, Shchepinov, Mikhail S., Sylantyev, Sergiy, Pavlov, Evgeny V., Klenerman, David, Abramov, Andrey Y., Gandhi, Sonia

“…Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that…”
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Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase by Ludtmann, Marthe H R, Angelova, Plamena R, Ninkina, Natalia N, Gandhi, Sonia, Buchman, Vladimir L, Abramov, Andrey Y

“…Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded…”
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Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis by Hughes, Craig D., Choi, Minee L., Ryten, Mina, Hopkins, Lee, Drews, Anna, Botía, Juan A., Iljina, Maria, Rodrigues, Margarida, Gagliano, Sarah A., Gandhi, Sonia, Bryant, Clare, Klenerman, David

“…Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial molecular events are unknown. Using LD score regression…”
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SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies by Ng, Kevin W, Faulkner, Nikhil, Finsterbusch, Katja, Wu, Mary, Harvey, Ruth, Hussain, Saira, Greco, Maria, Liu, Yafei, Kjaer, Svend, Swanton, Charles, Gandhi, Sonia, Beale, Rupert, Gamblin, Steve J, Cherepanov, Peter, McCauley, John, Daniels, Rodney, Howell, Michael, Arase, Hisashi, Wack, Andreas, Bauer, David L V, Kassiotis, George

“…Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged during the current coronavirus disease 2019 (COVID-19) pandemic…”
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Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading by Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christopher M., Knowles, Tuomas P. J., Klenerman, David

“…The protein alpha-synuclein (αS) self-assembles into small oligomeric species and subsequently into amyloid fibrils that accumulate and proliferate during the…”
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PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death by Gandhi, Sonia, Wood-Kaczmar, Alison, Yao, Zhi, Plun-Favreau, Helene, Deas, Emma, Klupsch, Kristina, Downward, Julian, Latchman, David S., Tabrizi, Sarah J., Wood, Nicholas W., Duchen, Michael R., Abramov, Andrey Y.

“…Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and…”
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Dopamine Induces Ca2+ Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase by Vaarmann, Annika, Gandhi, Sonia, Abramov, Andrey Y.

“…Dopamine is a neurotransmitter that plays a major role in a variety of brain functions, as well as in disorders such as Parkinson disease and schizophrenia. In…”
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PINK1 cleavage at position A103 by the mitochondrial protease PARL by DEAS, Emma, PLUN-FAVREAU, Helene, ABRAMOV, Andrey Y, WOOD, Nicholas W, GANDHI, Sonia, DESMOND, Howard, KJAER, Svend, LOH, Samantha H. Y, RENTON, Alan E. M, HARVEY, Robert J, WHITWORTH, Alexander J, MARTINS, L. Miguel

“…Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a…”
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Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation by Angelova, Plamena R., Barilani, Mario, Lovejoy, Christopher, Dossena, Marta, Viganò, Mariele, Seresini, Agostino, Piga, Daniela, Gandhi, Sonia, Pezzoli, Gianni, Abramov, Andrey Y., Lazzari, Lorenza

“…Sporadic cases account for 90–95% of all patients with Parkinson's Disease (PD). Atypical Parkinsonism comprises approximately 20% of all patients with…”
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Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach by Gandhi, Sonia, Chinnadurai, Vijayakumar, Bhadra, Kuntal, Gupta, Isha, Kanwar, Ratnesh Singh

“…The main physiological challenge in high altitude environment is hypoxia which affects the aerobic metabolism reducing the energy supply. These changes may…”
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Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS by Hall, Claire E., Yao, Zhi, Choi, Minee, Tyzack, Giulia E., Serio, Andrea, Luisier, Raphaelle, Harley, Jasmine, Preza, Elisavet, Arber, Charlie, Crisp, Sarah J., Watson, P. Marc D., Kullmann, Dimitri M., Abramov, Andrey Y., Wray, Selina, Burley, Russell, Loh, Samantha H.Y., Martins, L. Miguel, Stevens, Molly M., Luscombe, Nicholas M., Sibley, Christopher R., Lakatos, Andras, Ule, Jernej, Gandhi, Sonia, Patani, Rickie

“…Motor neurons (MNs) and astrocytes (ACs) are implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), but their interaction and the sequence of…”
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Improved antioxidant activities of spice require enrichment of distinct yet closely-related metabolic pathways by Gandhi, Sonia, Saha, Manas Ranjan, Dey, Priyankar

“…Improved biosynthesis of commercially and pharmacologically relevant phytometabolites through genetic and metabolic engineering is a lucrative strategy for…”
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 by Martins, L. Miguel, Downward, Julian, Plun-Favreau, Hélène, Klupsch, Kristina, Moisoi, Nicoleta, Gandhi, Sonia, Kjaer, Svend, Frith, David, Harvey, Kirsten, Deas, Emma, Harvey, Robert J, McDonald, Neil, Wood, Nicholas W

“…In mice, targeted deletion of the serine protease HtrA2 (also known as Omi) causes mitochondrial dysfunction leading to a neurodegenerative disorder with…”
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Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease by Tufi, Roberta, Gandhi, Sonia, de Castro, Inês P., Lehmann, Susann, Angelova, Plamena R., Dinsdale, David, Deas, Emma, Plun-Favreau, Hélène, Nicotera, Pierluigi, Abramov, Andrey Y., Willis, Anne E., Mallucci, Giovanna R., Loh, Samantha H. Y., Martins, L. Miguel

“…Mutations in PINK1 cause early-onset Parkinson’s disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1…”
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Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson’s disease by Devito, Liani G., Zanjani, Zeinab Shadman, Evans, James R., Scardamaglia, Annarita, Houlden, Henry, Gandhi, Sonia, Healy, Lyn

“…Mutations or multiplications of the SNCA (Synuclein Alpha) gene cause rare autosomal dominant Parkinson’s disease (PD). The SNCA G51D missense mutation is…”
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