Search Results - "GAN, K. K"

Antibody-Drug Conjugates for Cancer Therapy by Hafeez, Umbreen, Parakh, Sagun, Gan, Hui K, Scott, Andrew M

“…Antibody-drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells…”
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Demonstration of the propagation of errors using resistors by Gan, K. K.

“…We present a simple experiment to demonstrate the concept of propagation of errors by measuring resistors on printed circuit boards (PCBs). We devise a method…”
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The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered by Gan, Hui K., Cvrljevic, Anna N., Johns, Terrance G.

“…The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with…”
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A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors by Arnaud‐Coffin, Patrick, Maillet, Denis, Gan, Hui K., Stelmes, Jean‐Jacques, You, Benoit, Dalle, Stephane, Péron, Julien

“…The advent of immune checkpoint‐inhibitors (CPI) has transformed treatment for several cancer types. This review was performed to assess the rate of adverse…”
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A long-pulse high-confinement plasma regime in the Experimental Advanced Superconducting Tokamak by Li, J., Guo, H. Y., Wan, B. N., Gong, X. Z., Liang, Y. F., Xu, G. S., Gan, K. F., Hu, J. S., Wang, H. Q., Wang, L., Zeng, L., Zhao, Y. P., Denner, P., Jackson, G. L., Loarte, A., Maingi, R., Menard, J. E., Rack, M., Zou, X. L.

“…High-performance and long-pulse operation is a crucial goal of current magnetic fusion research. Here, we demonstrate a high-confinement plasma regime known as…”
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Adherence to CONSORT Adverse Event Reporting Guidelines in Randomized Clinical Trials Evaluating Systemic Cancer Therapy: A Systematic Review by PERON, Julien, MAILLET, Denis, GAN, Hui K, CHEN, Eric X, YOU, Benoit

“…The Consolidated Standards of Reporting Trials (CONSORT) guidance was extended in 2004 to provide a set of 10 specific and comprehensive guidelines regarding…”
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Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells by Gan, Hui K., van den Bent, Martin, Lassman, Andrew B., Reardon, David A., Scott, Andrew M.

“…Key Points Cell-surface antigens expressed on glioblastoma cells that have proven resistant to signalling inhibition approaches — whether by tyrosine-kinase…”
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The EGFRvIII variant in glioblastoma multiforme by Gan, Hui K, Kaye, Andrew H, Luwor, Rodney B

“…Abstract Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst prognosis. Epidermal growth factor receptor (EGFR) gene amplification,…”
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Targeting of a Conformationally Exposed, Tumor-Specific Epitope of EGFR as a Strategy for Cancer Therapy by GAN, Hui K, BURGESS, Antony W, CLAYTON, Andrew H. A, SCOTT, Andrew M

“…Epidermal growth factor receptor (EGFR) and its most common extracellular mutant, EGFRvIII, are important therapeutic targets in multiple cancer types. A…”
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The effects of acute hyponatraemia on bone turnover in patients with subarachnoid haemorrhage: A preliminary report by Garrahy, Aoife, Galloway, Iona, Hannon, Anne Marie, Dineen, Rosemary, Javadpour, Mohsen, Tormey, William P., Gan, KJ, Twomey, Patrick J., Mc Kenna, Malachi J., Kilbane, Mark, Crowley, Rachel K., Sherlock, Mark, Thompson, Christopher J.

“…Context Animal data and cross‐sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute…”
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An atomtronic flux qubit: a ring lattice of Bose-Einstein condensates interrupted by three weak links by Aghamalyan, D, Nguyen, N T, Auksztol, F, Gan, K S, Valado, M Martinez, Condylis, P C, Kwek, L-C, Dumke, R, Amico, L

“…We study a physical system consisting of a Bose-Einstein condensate confined to a ring shaped lattice potential interrupted by three weak links. The system is…”
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Consistency in the Analysis and Reporting of Primary End Points in Oncology Randomized Controlled Trials From Registration to Publication: A Systematic Review by YOU, Benoit, GAN, Hui K, POND, Gregory, CHEN, Eric X

“…To improve the quality of reporting of randomized clinical trials (RCTs), international registries for RCTs and guidelines for primary end point (PEP) analysis…”
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Antibody Targeting of Eph Receptors in Cancer by Janes, Peter W, Vail, Mary E, Gan, Hui K, Scott, Andrew M

“…The Eph subfamily of receptor tyrosine kinases mediate cell-cell communication controlling cell and tissue patterning during development. While generally less…”
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Changes in the Use of Comprehensive Geriatric Assessment in Clinical Trials for Older Patients with Cancer over Time by Le Saux, Olivia, Falandry, Claire, Gan, Hui K., You, Benoit, Freyer, Gilles, Péron, Julien

“…Background The objective of this study was to describe the implementation of comprehensive geriatric assessment (CGA) in clinical trials dedicated to older…”
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A Phase I, First‐in‐Human Study of GSK2849330, an Anti‐HER3 Monoclonal Antibody, in HER3‐Expressing Solid Tumors by Gan, Hui K., Millward, Michael, Jalving, Mathilde, Garrido‐Laguna, Ignacio, Lickliter, Jason D., Schellens, Jan H.M., Lolkema, Martijn P., Van Herpen, Carla L.M., Hug, Bruce, Tang, Lihua, O'Connor‐Semmes, Robin, Gagnon, Robert, Ellis, Catherine, Ganji, Gopinath, Matheny, Christopher, Drilon, Alexander

“…Background GSK2849330, an anti‐HER3 monoclonal antibody that blocks HER3/Neuregulin 1 (NRG1) signaling in cancer cells, is engineered for enhanced…”
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Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer by GAN, Hui K, YOU, Benoit, POND, Gregory R, CHEN, Eric X

“…In designing phase III randomized clinical trials (RCTs), the expected magnitude of the benefit of the experimental therapy (δ) determines the number of…”
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Beyond standard data collection - the promise and potential of BRAIN (Brain tumour Registry Australia INnovation and translation registry) by Gately, Lucy, Drummond, Katharine, Rosenthal, Mark, Harrup, Rosemary, Dowling, Anthony, Gogos, Andrew, Lwin, Zarnie, Collins, Ian, Campbell, David, Ahern, Elizabeth, Phillips, Claire, Gan, Hui K, Bennett, Iwan, Sieber, Oliver M, Gibbs, Peter

“…Real-world data (RWD) is increasingly being embraced as an invaluable source of information to address clinical and policy-relevant questions that are unlikely…”
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Texture-based classification of liver fibrosis using MRI by House, Michael J., Bangma, Sander J., Thomas, Mervyn, Gan, Eng K., Ayonrinde, Oyekoya T., Adams, Leon A., Olynyk, John K., St. Pierre, Tim G.

“…Purpose To investigate the ability of texture analysis of MRI images to stage liver fibrosis. Current noninvasive approaches for detecting liver fibrosis have…”
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Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography by Dickmann, Catherine G Fitzgerald, McDonald, Alexander F, Huynh, Nhi, Rigopoulos, Angela, Liu, Zhanqi, Guo, Nancy, Osellame, Laura D, Gorman, Michael A, Parker, Michael W, Gan, Hui K, Scott, Andrew M, Ackermann, Uwe, Burvenich, Ingrid J G, White, Jonathan M

“…Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. BET proteins have not been…”
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Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug Conjugate by Phillips, Andrew C, Boghaert, Erwin R, Vaidya, Kedar S, Falls, Hugh D, Mitten, Michael J, DeVries, Peter J, Benatuil, Lorenzo, Hsieh, Chung-Ming, Meulbroek, Jonathan A, Panchal, Sanjay C, Buchanan, Fritz G, Durbin, Kenneth R, Voorbach, Martin J, Reuter, David R, Mudd, Sarah R, Loberg, Lise I, Ralston, Sherry L, Cao, Diana, Gan, Hui K, Scott, Andrew M, Reilly, Edward B

“…Depatuxizumab mafodotin (depatux-m, ABT-414) is a tumor-selective antibody drug conjugate (ADC) comprised of the anti-EGFR antibody ABT-806 and the monomethyl…”
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