Search Results - "GAMMELTOFT, S"

Do microRNAs target hypocretin? by Holm, A, Thomas, J, Gammeltoft, S, Jennum, P, Kornum, B

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Intravenous immunoglobulin treatment and screening for hypocretin neuron-specific autoantibodies in recent onset childhood narcolepsy with cataplexy by Knudsen, S, Mikkelsen, J D, Bang, B, Gammeltoft, S, Jennum, P J

“…Narcolepsy with cataplexy (NC) is caused by substantial loss of hypocretin neurons. NC patients carry the HLA-DQB1*0602 allele suggesting that hypocretin…”
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EIF3G is associated to narcolepsy by Holm, A, Mostafavi, S, Gammeltoft, S, Jennum, P, Kornum, B, Mignot, E

“…Introduction A previous GWA study found an association between narcolepsy and SNPs in P2RY11. Later a missense mutation in DNMT1 was discovered to cause a rare…”
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miRNA profiling in plasma from patients with sleep disorders reveals dysregulation of miRNAs in narcolepsy and other central hypersomnias by Holm, A, Bang-Berthelsen, C, Knudsen, S, Kornum, B, Jennum, P, Gammeltoft, S

“…Introduction miRNAs have been implicated in the pathogenesis of human diseases including neurological disorders. The aim is to address the involvement of…”
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β‐Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high‐affinity conformations by Sanni, SJ, Hansen, JT, Bonde, MM, Speerschneider, T, Christensen, GL, Munk, S, Gammeltoft, S, Hansen, JL

“…BACKGROUND AND PURPOSE The angiotensin II type 1 (AT1) receptor belongs to family A of 7 transmembrane (7TM) receptors. The receptor has important roles in the…”
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P9-10 REM sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency by Knudsen, S, Gammeltoft, S, Jennum, P

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P9-11 Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population by Knudsen, S, Jennum, P, Alving, J, Sheikh, S, Gammeltoft, S

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Insulin receptors: binding kinetics and structure-function relationship of insulin by Gammeltoft, S

“…During the last decade, earlier suggestions that insulin acts at the plasma membrane level via combination with receptors have been amply confirmed in studies…”
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Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis by Knudsen, S, Jennum, PJ, Korsholm, K, Sheikh, SP, Gammeltoft, S, Frederiksen, JL

“…There is emerging evidence that multiple sclerosis (MS), the hypothalamic sleep-wake regulating neuropeptide hypocretin-1 (hcrt-1) and the sleep disorder…”
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Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function by Nielsen, L. B, Mortensen, H. B, Chiarelli, F, Holl, R, Swift, P, de Beaufort, C, Pociot, F, Hougaard, P, Gammeltoft, S, Knip, M, Hansen, L

“…Aims/hypothesis The insulin-dependent diabetes mellitus 2 gene (IDDM2) is a type 1 diabetes susceptibility locus contributed to by the variable number of…”
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Translational discrimination of mRNAs coding for human insulin-like growth factor II by NIELSEN, F. C, GAMMELTOFT, S, CHRISTIANSEN, J

“…Sucrose gradient and Northern analyses were used to study the translational status of endogenous multiple mRNAs encoding the prepropeptide for human…”
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Insulin-Like Growth Factors Act Synergistically with Basic Fibroblast Growth Factor and Nerve Growth Factor to Promote Chromaffin Cell Proliferation by Frodin, Morten, Gammeltoft, Steen

“…We have investigated the effects of insulin-like growth factors (IGFs), basic fibroblast growth factor (bFGF), and nerve growth factor (NGF) on DNA synthesis…”
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Neuronal localization of pituitary adenylate cyclase-activating polypeptide 38 in the adrenal medulla and growth-inhibitory effect on chromaffin cells by Frödin, M., Hannibal, J., Wulff, B.S., Gammeltoft, S., Fahrenkrug, J.

“…The chromaffin cells of the adult rat adrenal medulla are essentially growth arrested in situ, but can proliferate in vitro, suggesting the existence of growth…”
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Deletion of V335 from the L2 Domain of the Insulin Receptor Results in a Conformationally Abnormal Receptor That Is Unable to Bind Insulin and Causes Donohue’s Syndrome in a Human Subject by George, S, Johansen, A, Soos, M. A, Mortensen, H, Gammeltoft, S, Saudek, V, Siddle, K, Hansen, L, O’Rahilly, S

“…An infant with Donohue’s syndrome (leprechaunism) was found to be homozygous for an in-frame trinucleotide deletion within the insulin receptor gene resulting…”
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Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency by Knudsen, Stine, Gammeltoft, Steen, Jennum, Poul J.

“…Rapid eye movement sleep behaviour disorder is characterized by dream-enacting behaviour and impaired motor inhibition during rapid eye movement sleep. Rapid…”
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Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells by Drejer, K., Kruse, V., Larsen, U. D., Hougaard, P., Bjorn, S., Gammeltoft, S.

“…Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells. K Drejer , V Kruse , U D…”
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Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase by Grønborg, M, Wulff, B.S., Rasmussen, J.S., Kjeldsen, T, Gammeltoft, S

“…Insulin-like growth factor I (IGF-I) and insulin receptors are structurally similar with ligand-stimulated tyrosine kinase activity in their cytoplasmic…”
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Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence by Blom, Nikolaj, Sicheritz-Pontén, Thomas, Gupta, Ramneek, Gammeltoft, Steen, Brunak, Søren

“…Post‐translational modifications (PTMs) occur on almost all proteins analyzed to date. The function of a modified protein is often strongly affected by these…”
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Serotonin metabolism in chronic tension-type headache by Bendtsen, L, Jensen, R, Hindberg, I, Gammeltoft, S, Olesen, J

“…Serotonergic neurons play a major role in the regulation of pain and may therefore also be involved in the pathophysiology of tension-type headache. Platelets…”
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Sequence and structure-based prediction of eukaryotic protein phosphorylation sites by Blom, Nikolaj, Gammeltoft, Steen, Brunak, Søren

“…Protein phosphorylation at serine, threonine or tyrosine residues affects a multitude of cellular signaling processes. How is specificity in substrate…”
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