Search Results - "GAMARRO, Francisco"

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge by Ponte-Sucre, Alicia, Gamarro, Francisco, Dujardin, Jean-Claude, Barrett, Michael P, López-Vélez, Rogelio, García-Hernández, Raquel, Pountain, Andrew W, Mwenechanya, Roy, Papadopoulou, Barbara

“…Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently needed on a global basis because treatment failure is an increasing…”
Get full text

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes by Mondelaers, Annelies, Sanchez-Cañete, Maria P, Hendrickx, Sarah, Eberhardt, Eline, Garcia-Hernandez, Raquel, Lachaud, Laurence, Cotton, James, Sanders, Mandy, Cuypers, Bart, Imamura, Hideo, Dujardin, Jean-Claude, Delputte, Peter, Cos, Paul, Caljon, Guy, Gamarro, Francisco, Castanys, Santiago, Maes, Louis

“…During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a…”
Get full text

Leishmania donovani develops resistance to drug combinations by García-Hernández, Raquel, Manzano, José Ignacio, Castanys, Santiago, Gamarro, Francisco

“…Drug combinations for the treatment of leishmaniasis represent a promising and challenging chemotherapeutic strategy that has recently been implemented in…”
Get full text

Complete assembly of the Leishmania donovani (HU3 strain) genome and transcriptome annotation by Camacho, Esther, González-de la Fuente, Sandra, Rastrojo, Alberto, Peiró-Pastor, Ramón, Solana, Jose Carlos, Tabera, Laura, Gamarro, Francisco, Carrasco-Ramiro, Fernando, Requena, Jose M., Aguado, Begoña

“…Leishmania donovani is a unicellular parasite that causes visceral leishmaniasis, a fatal disease in humans. In this study, a complete assembly of the genome…”
Get full text

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs by Rastrojo, Alberto, García-Hernández, Raquel, Vargas, Paola, Camacho, Esther, Corvo, Laura, Imamura, Hideo, Dujardin, Jean-Claude, Castanys, Santiago, Aguado, Begoña, Gamarro, Francisco, Requena, Jose M.

“…Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing…”
Get full text

Strasseriolides display in vitro and in vivo activity against trypanosomal parasites and cause morphological and size defects in Trypanosoma cruzi by Bosch-Navarrete, Cristina, Pérez-Moreno, Guiomar, Annang, Frederick, Diaz-Gonzalez, Rosario, García-Hernández, Raquel, Rocha, Hedy, Gamarro, Francisco, Cordón-Obras, Carlos, Navarro, Miguel, Rodriguez, Ana, Genilloud, Olga, Reyes, Fernando, Vicente, Francisca, Ruiz-Pérez, Luis M, González-Pacanowska, Dolores

“…Neglected diseases caused by kinetoplastid parasites are a health burden in tropical and subtropical countries. The need to create safe and effective medicines…”
Get full text

Fitness of Leishmania donovani parasites resistant to drug combinations by García-Hernández, Raquel, Gómez-Pérez, Verónica, Castanys, Santiago, Gamarro, Francisco

“…Drug resistance represents one of the main problems for the use of chemotherapy to treat leishmaniasis. Additionally, it could provide some advantages to…”
Get full text

Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti-Inflammatory Properties by Sánchez-Fernández, Elena M., García-Hernández, Raquel, Gamarro, Francisco, Arroba, Ana I., Aguilar-Diosdado, Manuel, Padrón, José M., García Fernández, José M., Ortiz Mellet, Carmen

“…sp2-Iminosugar glycolipids (sp2-IGLs) represent a consolidated family of glycoconjugate mimetics encompassing a monosaccharide-like glycone moiety with a…”
Get full text

The 8-Aminoquinoline Analogue Sitamaquine Causes Oxidative Stress in Leishmania donovani Promastigotes by Targeting Succinate Dehydrogenase by Carvalho, Luis, Luque-Ortega, Juan Román, López-Martín, Carmen, Castanys, Santiago, Rivas, Luis, Gamarro, Francisco

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine by YARDLEY, Vanessa, GAMARRO, Francisco, CROFT, Simon L

“…ERRATUM ( vol. 55 , p. 458 ) Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
Get full text

Arylthiosemicarbazones as antileishmanial agents by Manzano, José Ignacio, Cochet, Florent, Boucherle, Benjamin, Gómez-Pérez, Verónica, Boumendjel, Ahcène, Gamarro, Francisco, Peuchmaur, Marine

“…Based on a screening process, we targeted substituted thiosemicarbazone as potential antileishmanial agents. Our objective was to identify the key structural…”
Get full text

The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei by Carvalho, Luis, Martínez-García, Marta, Pérez-Victoria, Ignacio, Manzano, José Ignacio, Yardley, Vanessa, Gamarro, Francisco, Pérez-Victoria, José M

“…The protozoan parasite Trypanosoma brucei causes human African trypanosomiasis, or sleeping sickness, a neglected tropical disease that requires new, safer,…”
Get full text

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis by CARVALHO, Luis, LUQUE-ORTEGA, Juan Román, MANZANO, José Ignacio, CASTANYS, Santiago, RIVAS, Luis, GAMARRO, Francisco

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development by Cavazzuti, Antonio, Paglietti, Giuseppe, Hunter, William N, Gamarro, Francisco, Piras, Sandra, Loriga, Mario, Allecca, Sergio, Corona, Paola, McLuskey, Karen, Tulloch, Lindsay, Gibellini, Federica, Ferrari, Stefania, Costi, Maria Paola

“…Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. To…”
Get full text

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes by Ferrins, Lori, Buskes, Melissa J, Kapteyn, Madison M, Engels, Hannah N, Enos, Suzanne E, Lu, Chenyang, Klug, Dana M, Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F, Spaulding, Andrew E, Forbes, Katherine C, Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R, Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P, Kyle, Dennis E, Rice, Christopher A

“…species, , and are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic…”
Get full text

Modulation of Cholesterol Pathways in Human Macrophages Infected by Clinical Isolates of Leishmania infantum by Manzano, José Ignacio, Perea-Martínez, Ana, García-Hernández, Raquel, Andrés-León, Eduardo, Terrón-Camero, Laura C, Poveda, José Antonio, Gamarro, Francisco

“…To increase our understanding of factors contributing to therapeutic failure (TF) in leishmaniasis, we have studied some plasma membrane features of host THP-1…”
Get full text

Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes by Ferrins, Lori, Buskes, Melissa J., Kapteyn, Madison M., Engels, Hannah N., Enos, Suzanne E., Lu, Chenyang, Klug, Dana M., Singh, Baljinder, Quotadamo, Antonio, Bachovchin, Kelly, Tear, Westley F., Spaulding, Andrew E., Forbes, Katherine C., Bag, Seema, Rivers, Mitch, LeBlanc, Catherine, Burchfield, Erin, Armand, Jeremy R., Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, García-Hernández, Raquel, Pérez-Moreno, Guiomar, Bosch-Navarrete, Cristina, Gómez-Liñán, Claudia, Ruiz-Pérez, Luis Miguel, Gamarro, Francisco, González-Pacanowska, Dolores, Navarro, Miguel, Mensa-Wilmot, Kojo, Pollastri, Michael P., Kyle, Dennis E., Rice, Christopher A.

“…[This corrects the article DOI: 10.3389/fmicb.2023.1149145.]…”
Get full text

Phospholipid Translocation and Miltefosine Potency Require Both L. donovani Miltefosine Transporter and the New Protein LdRos3 in Leishmania Parasites by Pérez-Victoria, F. Javier, Sánchez-Cañete, María P., Castanys, Santiago, Gamarro, Francisco

“…The antitumor drug miltefosine has been recently approved as the first oral drug active against visceral leishmaniasis. We have previously identified the L…”
Get full text

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit by García-Sánchez, Sebastián, Sánchez-Cañete, María P, Gamarro, Francisco, Castanys, Santiago

“…Cdc50 (cell-cycle control protein 50) is a family of conserved eukaryotic proteins that interact with P4-ATPases (phospholipid translocases). Cdc50 association…”
Get more information

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids by Sánchez-Fernández, Elena M., García-Moreno, M. Isabel, García-Hernández, Raquel, Padrón, José M., García Fernández, José M., Gamarro, Francisco, Ortiz Mellet, Carmen

“…The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical…”
Get full text