Search Results - "GAMARRO, F"

A New ABC Half-Transporter in Leishmania major Is Involved in Resistance to Antimony by MANZANO, J. I, GARCIA-HERNANDEZ, R, CASTANYS, S, GAMARRO, F

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease by Annang, F, Pérez-Moreno, G, García-Hernández, R, Cordon-Obras, C, Martín, J, Tormo, J R, Rodríguez, L, de Pedro, N, Gómez-Pérez, V, Valente, M, Reyes, F, Genilloud, O, Vicente, F, Castanys, S, Ruiz-Pérez, L M, Navarro, M, Gamarro, F, González-Pacanowska, D

“…African trypanosomiasis, leishmaniasis, and Chagas disease are 3 neglected tropical diseases for which current therapeutic interventions are inadequate or…”
Get more information

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use by Pérez-Victoria, F. Javier, Sánchez-Cañete, María P., Seifert, Karin, Croft, Simon L., Sundar, Shyam, Castanys, Santiago, Gamarro, Francisco

“…Miltefosine (hexadecylphosphocholine, MIL), registered as Impavido ®, has become the first oral drug for the treatment of visceral and cutaneous leishmanasis…”
Get full text

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters by Di Pietro, A, Conseil, G, Pérez-Victoria, J.M, Dayan, G, Baubichon-Cortay, H, Trompier, D, Steinfels, E, Jault, J.-M, de Wet, H, Maitrejean, M, Comte, G, Boumendjel, A, Mariotte, A.-M, Dumontet, C, McIntosh, D.B, Goffeau, A, Castanys, S, Gamarro, F, Barron, D

“…Cancer cell resistance to chemotherapy is often mediated by overexpression of P-glycoprotein, a plasma membrane ABC (ATP-binding cassette) transporter which…”
Get full text

Multidrug resistance phenotype mediated by the P-glycoprotein-like transporter in Leishmania: a search for reversal agents by Pérez-Victoria, J M, Di Pietro, A, Barron, D, Ravelo, A G, Castanys, S, Gamarro, F

“…Protozoan parasites are responsible for important diseases that threaten the lives of nearly one-quarter of the human population world-wide. Among them,…”
Get more information

Alkyl-Lysophospholipid Resistance in Multidrug-Resistant Leishmania tropica and Chemosensitization by a Novel P-Glycoprotein-Like Transporter Modulator by Pérez-Victoria, José M, Pérez-Victoria, F. Javier, Parodi-Talice, Adriana, Jiménez, Ignacio A, Ravelo, Angel G, Castanys, Santiago, Gamarro, Francisco

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Chemosensitization of a Multidrug-Resistant Leishmania tropica Line by New Sesquiterpenes from Maytenus magellanica and Maytenus chubutensis by Kennedy, María L, Cortés-Selva, Fernando, Pérez-Victoria, José M, Jiménez, Ignacio A, González, Antonio G, Muñoz, Orlando M, Gamarro, Francisco, Castanys, Santiago, Ravelo, Angel G

“…Parasite resistance to drugs has emerged as a major problem in current medicine, and therefore, there is great clinical interest in developing compounds that…”
Get full text

Protein Kinase C Effectors Bind to Multidrug ABC Transporters and Inhibit Their Activity by Conseil, Gwenaëlle, Perez-Victoria, José Maria, Jault, Jean-Michel, Gamarro, Francisco, Goffeau, André, Hofmann, Johann, Di Pietro, Attilio

“…P-Glycoprotein and homologous multidrug transporters contain a phosphorylatable linker sequence that was proposed to control drug efflux on the basis that it…”
Get full text

Correlation between the Affinity of Flavonoids Binding to the Cytosolic Site of Leishmania tropica Multidrug Transporter and Their Efficiency To Revert Parasite Resistance to Daunomycin by Pérez-Victoria, José M, Chiquero, M. Jesús, Conseil, Gwenaëlle, Dayan, Guila, Di Pietro, Attilio, Barron, Denis, Castanys, Santiago, Gamarro, Francisco

“…The C-terminal nucleotide-binding domain (NBD2) of a P-glycoprotein-like transporter, encoded by the ltrmdr1 gene in Leishmania tropica and involved in…”
Get full text

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin by PEREZ-VICTORIA, Jose M, PEREZ-VICTORIA, F. Javier, CONSEIL, Gwenaëlle, MAITREJEAN, Mathias, COMTE, Gilles, BARRON, Denis, DI PIETRO, Attilio, CASTANYS, Santiago, GAMARRO, Francisco

“…In order to overcome the multidrug resistance mediated by P-glycoprotein-like transporters in Leishmania spp., we have studied the effects produced by…”
Get full text

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance by Perez-Victorias, F J, Conseil, G, Munoz-Martinez, F, Perez-Victoria, J M, Dayan, G, Marsaud, V, Castanys, S, Gamarro, F, Renoir, J M, Di Pietro, A

“…Progesterone and the antiprogestin RU38486 have been reported as non-transported modulators of P-glycoprotein-mediated drug efflux. However, their hormonal…”
Get full text

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi by Dallagiovanna, Bruno, Gamarro, Francisco, Castanys, Santiago

“…We have cloned, sequenced and characterized a gene from Trypanosoma cruzi (Y strain), termed tcpgp2, which encodes a member of the ABC (ATP-binding cassette)…”
Get full text

Increased P-type ATPase activity in Leishmania tropica resistant to methotrexate by Sanchez, A, Castanys, S, Gamarro, F

“…In the present report, we show evidence that the membrane from the protozoan parasite Leishmania tropica (LRC-L39), in vitro resistant to 1 mM of methotrexate…”
Get more information

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance by Pérez-Victoria, F Javier, Gamarro, Francisco, Ouellette, Marc, Castanys, Santiago

“…The antitumor drug miltefosine (hexadecylphosphocholine, MIL) has recently been approved as the first oral agent for the treatment of visceral leishmaniasis…”
Get full text

Leishmania donovani Resistance to Miltefosine Involves a Defective Inward Translocation of the Drug by Pérez-Victoria, F Javier, Castanys, Santiago, Gamarro, Francisco

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2 by AHMED-BELKACEM, Abdelhakim, POZZA, Alexandre, MUNOZ-MARTINEZ, Francisco, BATES, Susan E, CASTANYS, Santiago, GAMARRO, Francisco, DI PIETRO, Attilio, PEREZ-VICTORIA, José M

“…Overexpression of breast cancer resistance protein ABCG2 confers multidrug resistance in cancer cells. The GF120918-sensitive drug efflux activity of human…”
Get full text

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening by Manzano, José Ignacio, Lecerf-Schmidt, Florine, Lespinasse, Marie-Ange, Di Pietro, Attilio, Castanys, Santiago, Boumendjel, Ahcène, Gamarro, Francisco

“…To identify reversal agents for the Leishmania ABCI4 transporter that confers resistance to antimony. Selective ABCI4 inhibitors among a series of 15 flavonoid…”
Get full text

Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene by Dallagiovanna, B, Castanys, S, Gamarro, F

Get more information

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine) by Seifert, Karin, Matu, Sangeeta, Javier Pérez-Victoria, F., Castanys, Santiago, Gamarro, Francisco, Croft, Simon L.

“…Leishmania donovani promastigote lines resistant to hexadecylphosphocholine (HePC, miltefosine) at 2.5, 5.0, 10.0, 20.0 and 40.0 μM were developed in vitro by…”
Get full text

Trypanosoma cruzi: calcium ion movement during internalization in host HeLa cells by Osuna, A, Castanys, S, Rodriguez-Cabezas, M N, Gamarro, F

“…The role of cytosolic Ca2+ and cytoplasmic calcium movement during the parasitization of HeLa cells by T. cruzi were studied. The level of calcium in…”
Get more information