Search Results - "GALLO, James M"

Epigenetic instability may alter cell state transitions and anticancer drug resistance by Saini, Anshul, Gallo, James M

“…Drug resistance is a significant obstacle to successful and durable anti-cancer therapy. Targeted therapy is often effective during early phases of treatment;…”
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Hybrid physiologically‐based pharmacokinetic model for remdesivir: Application to SARS‐CoV‐2 by Gallo, James M.

“…A novel coronavirus, severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) or coronavirus disease 2019 (COVID‐19), has caused a pandemic that continues…”
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Impact of Angiogenesis Inhibition by Sunitinib on Tumor Distribution of Temozolomide by QINGYU ZHOU, PING GUO, GALLO, James M

“…Purpose: As combination chemotherapy of antiangiogenic agents with conventional chemotherapeutic drugs continues to evolve, an understanding of the…”
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Cell state‐directed therapy – epigenetic modulation of gene transcription demonstrated with a quantitative systems pharmacology model of temozolomide by Saini, Anshul, Ballesta, Annabelle, Gallo, James M.

“…Cancer therapy continues to be plagued by modest therapeutic advances. This is particularly evident in glioblastoma multiforme (GBM) wherein treatment failures…”
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New strategies to deliver anticancer drugs to brain tumors by Laquintana, Valentino, Trapani, Adriana, Denora, Nunzio, Wang, Fan, Gallo, James M, Trapani, Giuseppe

“…Malignant brain tumors are among the most challenging to treat and at present there are no uniformly successful treatment strategies. Standard treatment…”
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Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity by van Hasselt, J. G. Coen, Rahman, Rayees, Hansen, Jens, Stern, Alan, Shim, Jaehee V., Xiong, Yuguang, Pickard, Amanda, Jayaraman, Gomathi, Hu, Bin, Mahajan, Milind, Gallo, James M., Goldfarb, Joseph, Sobie, Eric A., Birtwistle, Marc R., Schlessinger, Avner, Azeloglu, Evren U., Iyengar, Ravi

“…Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although cardiotoxicity is a serious adverse event associated with several KIs, the…”
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Multiscale mapping of transcriptomic signatures for cardiotoxic drugs by Hansen, Jens, Xiong, Yuguang, Siddiq, Mustafa M., Dhanan, Priyanka, Hu, Bin, Shewale, Bhavana, Yadaw, Arjun S., Jayaraman, Gomathi, Tolentino, Rosa E., Chen, Yibang, Martinez, Pedro, Beaumont, Kristin G., Sebra, Robert, Vidovic, Dusica, Schürer, Stephan C., Goldfarb, Joseph, Gallo, James M., Birtwistle, Marc R., Sobie, Eric A., Azeloglu, Evren U., Berger, Seth I., Chan, Angel, Schaniel, Christoph, Dubois, Nicole C., Iyengar, Ravi

“…Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved…”
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Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models by Tiwari, Amit K, Sodani, Kamlesh, Dai, Chun-ling, Abuznait, Alaa H, Singh, Satyakam, Xiao, Zhi-Jie, Patel, Atish, Talele, Tanaji T, Fu, Liwu, Kaddoumi, Amal, Gallo, James M, Chen, Zhe-Sheng

“…Highlights ► Nilotinib compared to panel of tyrosine kinase inhibitors most potently reverse ABCB1, ABCG2 and ABCC10 transporters mediated drug resistance. ►…”
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Modulation of Cell State to Improve Drug Therapy by Gallo, James M.

“…A mainstay of drug therapy for brain tumors is the alkylating agent TMZ that invariably losses its effectiveness due to adaptive resistance. [...]the interplay…”
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Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity by Liu, Zhen, Yao, Yuan, Kogiso, Mari, Zheng, Baisong, Deng, Lisheng, Qiu, Jihui J, Dong, Shuo, Lv, Hua, Gallo, James M, Li, Xiao-Nan, Song, Yongcheng

“…Mutations of isocitrate dehydrogenase 1 (IDH1) are frequently found in certain cancers such as glioma. Different from the wild-type (WT) IDH1, the mutant…”
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Quantification of sunitinib in mouse plasma, brain tumor and normal brain using liquid chromatography–electrospray ionization-tandem mass spectrometry and pharmacokinetic application by Zhou, Qingyu, Gallo, James M.

“…The primary challenge associated with the development of an assay method for the determination of drug concentrations in relatively small amount of mouse…”
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A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients by ROSSO, Lula, BROCK, Cathryn S, GALLO, James M, SALEEM, Azeem, PRICE, Patricia M, TURKHEIMER, Federico E, ABOAGYE, Eric O

“…Difficulties in direct measurement of drug concentrations in human tissues have hampered the understanding of drug accumulation in tumors and normal tissues…”
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The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain by Sane, Ramola, Wu, Shu-Pei, Zhang, Rong, Gallo, James M

“…Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the blood-brain barrier (BBB) efflux transporters…”
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Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer by Bouhaddou, Mehdi, Yu, Li J., Lunardi, Serena, Stamatelos, Spyros K., Mack, Fiona, Gallo, James M., Birtwistle, Marc R., Walz, Antje‐Christine

“…Reliably predicting in vivo efficacy from in vitro data would facilitate drug development by reducing animal usage and guiding drug dosing in human clinical…”
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Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models by Tiwari, Amit K, Zhang, Rong, Gallo, James M

“…It is established that efflux transporters of the ATP-binding cassette (ABC) superfamily can affect the pharmacokinetics of drugs through mechanisms pertaining…”
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Quantitative Systems Pharmacology: A Foundation To Establish Precision Medicine–Editorial by Ballesta, Annabelle, Gallo, James M.

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Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib by Wang, Shining, Zhou, Qingyu, Gallo, James M

“…The goals of this investigation were to illustrate the use of pharmacokinetic (PK)/pharmacodynamic (PD) modeling strategies in drug development based on a…”
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Activation of alternate prosurvival pathways accounts for acquired sunitinib resistance in U87MG glioma xenografts by Zhou, Qingyu, Lv, Hua, Mazloom, Amin R, Xu, Huilei, Ma'ayan, Avi, Gallo, James M

“…Acquired drug resistance represents a major obstacle to using sunitinib for the treatment of solid tumors. Here, we examined the cellular and molecular…”
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Preclinical pharmacokinetic/pharmacodynamic models of gefitinib and the design of equivalent dosing regimens in EGFR wild-type and mutant tumor models by Wang, Shining, Guo, Ping, Wang, Xiaomin, Zhou, Qingyu, Gallo, James M

“…Epidermal growth factor receptor (EGFR) inhibitors, such as gefitinib, are examples of targeted anticancer drugs whose drug sensitivity is related to gene…”
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Predicting Human Tumor Drug Concentrations from a Preclinical Pharmacokinetic Model of Temozolomide Brain Disposition by QINGYU ZHOU, PING GUO, KRUH, Gary D, VICINI, Paolo, XIAOMIN WANG, GALLO, James M

“…Purpose: Knowledge of drug concentrations in tumors is critical for understanding the determinants of drug accumulation in tumors. Because significant…”
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