Search Results - "GALLIA, Gary L"
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Evaluation and Stability Analysis of Video-Based Navigation System for Functional Endoscopic Sinus Surgery on In Vivo Clinical Data
Published in IEEE transactions on medical imaging (01-10-2018)“…Functional endoscopic sinus surgery (FESS) is one of the most common outpatient surgical procedures performed in the head and neck region. It is used to treat…”
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Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
Published in Proceedings of the National Academy of Sciences - PNAS (04-08-2015)“…Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord…”
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Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
Published in Nature genetics (01-11-2014)“…Chetan Bettegowda, Bert Vogelstein and colleagues identify somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors from individuals with and…”
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Targeting the AKT pathway in glioblastoma
Published in Current pharmaceutical design (01-08-2011)“…Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. The treatment options for patients diagnosed with GBM are limited and the…”
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A comparative analysis of the Hospital Frailty Risk Score in predicting postoperative outcomes among intracranial tumor patients
Published in Journal of neurosurgery (01-08-2023)“…In recent years, frailty indices such as the 11- and 5-factor modified frailty indices (mFI-11 and mFI-5), American Society of Anesthesiologists (ASA) physical…”
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Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
Published in Neuro-oncology (Charlottesville, Va.) (01-09-2011)“…Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine…”
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A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer
Published in Nature communications (17-08-2022)“…Despite therapeutic advancements, oral cavity squamous cell carcinoma (OCSCC) remains a difficult disease to treat. Systemic platinum-based chemotherapy often…”
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Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model
Published in Clinical cancer research (01-08-2015)“…Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma. Three different mebendazole…”
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Effects of In Utero EtOH Exposure on 18S Ribosomal RNA Processing: Contribution to Fetal Alcohol Spectrum Disorder
Published in International journal of molecular sciences (01-09-2023)“…Fetal alcohol spectrum disorders (FASD) are leading causes of neurodevelopmental disability. The mechanisms by which alcohol (EtOH) disrupts fetal brain…”
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The Relevance of Simpson Grade Resections in Modern Neurosurgical Treatment of World Health Organization Grade I, II, and III Meningiomas
Published in World neurosurgery (01-01-2018)“…The Simpson grading system has played an important role in surgical resections of meningiomas. The aim of this study was to determine if this grading system…”
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Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model
Published in PloS one (06-04-2016)“…Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes…”
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Surgical Resection for Primary Central Nervous System Lymphoma: A Systematic Review
Published in World neurosurgery (01-06-2019)“…Primary central nervous system lymphomas (PCNSLs) account for 1%–2% of primary central nervous system tumors. Until recently, treatment has centered on biopsy,…”
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Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses
Published in Journal of translational medicine (31-05-2024)“…Olfactory neuroblastoma is a rare malignancy of the anterior skull base typically treated with surgery and adjuvant radiation. Although outcomes are fair for…”
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Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Published in Cancer research (Chicago, Ill.) (15-05-2014)“…Overexpression of the antiapoptotic protein Bcl-2 is observed in the majority of small cell lung cancer (SCLC) cases and is associated with resistance to…”
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Risk Factors for Preoperative Seizures and Loss of Seizure Control in Patients Undergoing Surgery for Metastatic Brain Tumors
Published in World neurosurgery (01-08-2017)“…Abstract Objective Metastatic brain tumors are the most common brain tumors in adults. Patients with metastatic brain tumors have poor prognoses with median…”
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TLR9 is critical for glioma stem cell maintenance and targeting
Published in Cancer research (Chicago, Ill.) (15-09-2014)“…Understanding supports for cancer stem-like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the…”
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Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma
Published in Nature communications (21-12-2018)“…Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for…”
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Assessment of frozen section margin analysis during olfactory neuroblastoma surgery
Published in The Laryngoscope (01-08-2017)“…Objectives 1) assess the performance of the intraoperative frozen section procedure to correctly classify biopsies obtained during olfactory neuroblastoma…”
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