Search Results - "GALLENNE, Tristan"

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis by Desmet, Christophe J., Gallenne, Tristan, Prieur, Alexandre, Reyal, Fabien, Visser, Nils L., Wittner, Ben S., Smit, Marjon A., Geiger, Thomas R., Laoukili, Jamila, Iskit, Sedef, Rodenko, Boris, Zwart, Wilbert, Evers, Bastiaan, Horlings, Hugo, Ajouaou, Abderrahrim, Zevenhoven, John, van Vliet, Martin, Ramaswamy, Sridhar, Wessels, Lodewyk F. A., Peeper, Daniel S.

“…Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are…”
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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members by Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A, Geneste, Olivier, Cartron, Pierre-François, Vallette, François M, Manon, Stephen, Juin, Philippe

“…It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding…”
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Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade by Geuijen, Cecile A.W., De Nardis, Camilla, Maussang, David, Rovers, Eric, Gallenne, Tristan, Hendriks, Linda J.A., Visser, Therese, Nijhuis, Roy, Logtenberg, Ton, de Kruif, John, Gros, Piet, Throsby, Mark

“…HER2-driven cancers require phosphatidylinositide-3 kinase (PI3K)/Akt signaling through HER3 to promote tumor growth and survival. The therapeutic benefit of…”
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Abstract 957: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signalling in tumor cells by docking on HER2 by Geuijen, Cecile, Maussang-Detaille, David, Gallenne, Tristan, Hendriks, Linda, Kramer, Arjen, Gerlach, Jan, Throsby, Mark, de Kruif, John

“…Abstract HER2-driven cancers require phosphatidylinositide-3 kinase (PI3K)/Akt signaling through HER3 to promote tumor growth and survival. The HER2/HER3…”
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Abstract 952: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP by de Gorter, David J., Deshiere, Alexandre, van Rosmalen, Martijn, Wohn, Christian, Eppink, Berina, Gallenne, Tristan, Klooster, Rinse, Mao, Li, Xu, Wenxin, Deng, Liang, Shu, Qingyu, Liu, Wei, de Kruif, John, Matteo, Mario Di, Mazzone, Massimiliano, Throsby, Mark, Geuijen, Cecile A.

“…Abstract MCLA-129 is an ADCC-enhanced common light chain bispecific human IgG1 Biclonics® antibody specifically targeting the receptor tyrosine kinases EGFR…”
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Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade by Geuijen, Cecile A.W., De Nardis, Camilla, Maussang, David, Rovers, Eric, Gallenne, Tristan, Hendriks, Linda J.A., Visser, Therese, Nijhuis, Roy, Logtenberg, Ton, de Kruif, John, Gros, Piet, Throsby, Mark

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Abstract LB-C07: Preclinical evaluation of MCLA-129: A bispecific antibody targeting c-MET and EGFR by Geuijen, Cecile, Matteo, Mario di, Gallenne, Tristan, Cafarello, Sarah Trusso, Nijhuis, Roy, Visser, Therese, Bartelink, Willem, Bartelink-Clements, Carina, Eppink, Berina, Klooster, Rinse, dekruif, John, Mazzone, Massimiliano, Throsby, Mark

“…Abstract NSCLC is the most common form of cancer. Approximately 20% of NSCLC patients have mutations in the growth factor (GF) receptor EGFR. These patients…”
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Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer by Gallenne, Tristan, Ross, Kenneth N, Visser, Nils L, Salony, Desmet, Christophe J, Wittner, Ben S, Wessels, Lodewyk F A, Ramaswamy, Sridhar, Peeper, Daniel S

“…Prognostic classifiers conceivably comprise biomarker genes that functionally contribute to the oncogenic and metastatic properties of cancer, but this has not…”
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The First α Helix of Bax Plays a Necessary Role in Its Ligand-Induced Activation by the BH3-Only Proteins Bid and PUMA by Cartron, Pierre-François, Gallenne, Tristan, Bougras, Gwenola, Gautier, Fabien, Manero, Florence, Vusio, Patricia, Meflah, Khaled, Vallette, François M., Juin, Philippe

“…The mechanism by which some BH3-only proteins of the Bcl-2 family directly activate the “multidomain” proapoptotic member Bax is poorly characterized. We…”
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Abstract 33: The binding mode of the bispecific anti-HER2xHER3 antibody MCLA-128 is responsible for its potent inhibition of HRG-driven tumorigenesis by Maussang-Detaille, David, Nardis, Camilla de, Hendriks, Linda, Bartelink-Clements, Carina, Rovers, Eric, Gallenne, Tristan, Doornbos, Robert, Bakker, Lex, Kruif, John de, Logtenberg, Ton, Gros, Piet, Geuijen, Cecile, Throsby, Mark

“…Abstract Introduction: MCLA-128 is as an ADCC-enhanced IgG1 bispecific antibody that targets the HER2:HER3 dimer and is currently being tested in Phase I/II…”
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The small organic compound HA14-1 prevents Bcl-2 interaction with bax to sensitize malignant glioma cells to induction of cell death by MANERO, Florence, GAUTIER, Fabien, GALLENNE, Tristan, CAUQUIL, Nicolas, GREE, Danielle, CARTRON, Pierre-Francois, GENESTE, Olivier, GREE, René, VALLETTE, Francois M, JUIN, Philippe

“…A functional imbalance between proapoptotic Bax and antiapoptotic Bcl-2 is likely to participate in the resistance of cancer cells to therapy. We show here…”
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Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer by Geuijen, Cecile, Rovers, Eric, Gallenne, Tristan, Maussang-Detaille, David, Kramer, Arjen, Nieuwenhuizen, Nellie, Clements, Carina, van Zoest, Katinka, Nijhuis, Roy, Visser, Therese, Den Blanken-Smit, Renate, Bartelink, Willem, Zondag-van der Zande, Vanessa, Kaldenberg, Linda, van Loo, Pieter-Fokko, Roovers, Rob, Doornbos, Robert, Price, Leo, Braam, Stefan, van Driel, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark

“…Abstract Background: MCLA-128 is an ADCC-enhanced humanized common light chain bispecific IgG1 antibody that targets the HER2:HER3 dimer with nanomolar…”
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Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer by Geuijen, Cecile, Rovers, Eric, Nijhuis, Roy, den Blanken-Smit, Renate, Visser, Therese, Bartelink, Willem, Kramer, Arjen, Zondag-van der Zande, Vanessa, Clements, Carina, Kaldenberg, Linda, Nieuwenhuizen, Nellie, van Loo, Pieter Fokko, Roovers, Rob, Gallenne, Tristan, Price, Leo, Van Driel Shamsili, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark

“…Abstract only…”
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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members by Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A., Geneste, Olivier, Cartron, Pierre-François, Vallette, François M., Manon, Stephen, Juin, Philippe

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