Search Results - "GALLANT, ESTHER M."

Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins by Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F., Dulhunty, Angela F.

“…We recently reported the isolation of a scorpion toxin named U₁-liotoxin-Lw1a (U₁-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed…”
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Flecainide Paradoxically Activates Cardiac Ryanodine Receptor Channels under Low Activity Conditions: A Potential Pro-Arrhythmic Action by Salvage, Samantha C, Gallant, Esther M, Fraser, James A, Huang, Christopher L-H, Dulhunty, Angela F

“…Cardiac ryanodine receptor (RyR2) mutations are implicated in the potentially fatal catecholaminergic polymorphic ventricular tachycardia (CPVT) and in atrial…”
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Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment by Hanna, Amy D, Lam, Alex, Thekkedam, Chris, Gallant, Esther M, Beard, Nicole A, Dulhunty, Angela F

“…Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in…”
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Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse by Salvage, Samantha C, Gallant, Esther M, Beard, Nicole A, Ahmad, Shiraz, Valli, Haseeb, Fraser, James A, Huang, Christopher L-H, Dulhunty, Angela F

“…Mutations in the cardiac ryanodine receptor Ca release channel (RyR2) can cause deadly ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S…”
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The elusive role of the SPRY2 domain in RyR1 by Tae, HanShen, Wei, Lan, Willemse, Hermia, Mirza, Shamaruh, Gallant, Esther M., Board, Philip G., Dirksen, Robert T., Casarotto, Marco Giovani, Dulhunty, Angela

“…The second of three SPRY domains (SPRY2, S1085 V1208) located in the skeletal muscle ryanodine receptor (RyR1) is contained within regions of RyR1 that…”
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Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding by Richardson, Spencer J, Steele, Gregory A, Gallant, Esther M, Lam, Alexander, Schwartz, Charles E, Board, Philip G, Casarotto, Marco G, Beard, Nicole A, Dulhunty, Angela F

“…Ryanodine receptor (RyR) Ca channels are central to striated muscle function and influence signalling in neurons and other cell types. Beneficially low RyR…”
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A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels by Li, Linwei, Mirza, Shamaruh, Richardson, Spencer J, Gallant, Esther M, Thekkedam, Chris, Pace, Suzy M, Zorzato, Francesco, Liu, Dan, Beard, Nicole A, Dulhunty, Angela F

“…Junctin, a non-catalytic splice variant encoded by the aspartate-β-hydroxylase (Asph) gene, is inserted into the membrane of the sarcoplasmic reticulum (SR)…”
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Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin by Wei, Lan, Gallant, Esther M., Dulhunty, Angela F., Beard, Nicole A.

“…Normal Ca2+ signalling in skeletal muscle depends on the membrane associated proteins triadin and junctin and their ability to mediate functional interactions…”
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Correction: Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment by Hanna, Amy D, Lam, Alex, Thekkedam, Chris, Gallant, Esther M, Beard, Nicole A, Dulhunty, Angela F

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The β1a Subunit of the Skeletal DHPR Binds to Skeletal RyR1 and Activates the Channel via Its 35-Residue C-Terminal Tail by Rebbeck, Robyn T., Karunasekara, Yamuna, Gallant, Esther M., Board, Philip G., Beard, Nicole A., Casarotto, Marco G., Dulhunty, Angela F.

“…Although it has been suggested that the C-terminal tail of the β 1a subunit of the skeletal dihyropyridine receptor (DHPR) may contribute to voltage-activated…”
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Redox potential and the response of cardiac ryanodine receptors to CLIC-2, a member of the glutathione S-transferase structural family by Jalilian, Chris, Gallant, Esther M, Board, Philip G, Dulhunty, Angela F

“…The type 2 chloride intracellular channel, CLIC-2, is a member of the glutathione S-transferase structural family and a suppressor of cardiac ryanodine…”
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Dissection of the inhibition of cardiac ryanodine receptors by human glutathione transferase GSTM2-2 by Liu, Dan, Hewawasam, Ruwani, Pace, Suzy M., Gallant, Esther M., Casarotto, Marco G., Dulhunty, Angela F., Board, Philip G.

“…The muscle specific glutathione transferase GSTM2-2 inhibits the activity of cardiac ryanodine receptor (RyR2) calcium release channels with high affinity and…”
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Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity by Wei, Lan, Abdellatif, Yasser A., Liu, Dan, Kimura, Takashi, Coggan, Marjorie, Gallant, Esther M., Beard, Nicole A., Board, Philip G., Dulhunty, Angela F.

“…We show that a glutathione transferase (GST) protein, which is recognised by an antibody against the muscle-specific human GSTM2-2 (hGSTM2-2), is associated…”
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The Mu class glutathione transferase is abundant in striated muscle and is an isoform-specific regulator of ryanodine receptor calcium channels by Abdellatif, Yasser, Liu, Dan, Gallant, Esther M, Gage, Peter W, Board, Philip G, Dulhunty, Angela F

“…Abstract Members of the glutathione transferase (GST) structural family are novel regulators of cardiac ryanodine receptor (RyR) calcium channels. We present…”
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Exclusion of linkage of the RYR1, CACNA1S, and ATP2A1 genes to recurrent exertional rhabdomyolysis in Thoroughbreds by Dranchak, P.K, Valberg, S.J, Onan, G.W, Gallant, E.M, Binns, M.M, Swinburne, J.E, Mickelson, J.R

“…To determine whether there was genetic linkage between the recurrent exertional rhabdomyolysis (RER) trait in Thoroughbred horse pedigrees and DNA markers in…”
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Inheritance of recurrent exertional rhabdomyolysis in Thoroughbreds by Dranchak, P.K, Valberg, S.J, Onan, G.W, Gallant, E.M, MacLeay, J.M, McKenzie, E.C, De La Corte, F.D, Ekenstedt, K, Mickelson, J.R

“…To develop a diagnostic test for recurrent exertional rhabdomyolysis (RER) in Thoroughbreds that relied on in vitro contracture of muscle biopsy specimens and…”
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Effects of an α-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: Modulation by Homer by Pouliquin, Pierre, Pace, Suzy M., Curtis, Suzanne M., Harvey, Peta J., Gallant, Esther M., Zorzato, Francesco, Casarotto, Marco G., Dulhunty, Angela F.

“…We have determined the structure of a domain peptide corresponding to the extreme 19 C-terminal residues of the ryanodine receptor Ca 2+ release channel. We…”
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Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide by Gallant, Esther M, Hart, James, Eager, Kevin, Curtis, Suzanne, Dulhunty, Angela F

“…Enhanced sensitivity to caffeine is part of the standard tests for susceptibility to malignant hyperthermia (MH) in humans and pigs. The caffeine sensitivity…”
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Myoplasmic calcium regulation in myotubes from horses with recurrent exertional rhabdomyolysis by Lentz, Linnea R, Valberg, Stephanie J, Herold, Lee V, Onan, Gary W, Mickelson, James R, Gallant, Esther M

“…Objective-To determine whether alterations in myoplasmic calcium regulation can be identified in muscle cell cultures (myotubes) and intact muscle fiber…”
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Activation and Inhibition of Skeletal RyR Channels by a Part of the Skeletal DHPR II-III Loop: Effects of DHPR Ser 687 and FKBP12 by Dulhunty, Angela F., Laver, Derek R., Gallant, Esther M., Casarotto, Marco G., Pace, Suzy M., Curtis, Suzanne

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