Search Results - "GALLACHER, J."

Why representativeness should be avoided by Rothman, Kenneth J, Gallacher, John E J, Hatch, Elizabeth E

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Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151) by Davies, G, Marioni, R E, Liewald, D C, Hill, W D, Hagenaars, S P, Harris, S E, Ritchie, S J, Luciano, M, Fawns-Ritchie, C, Lyall, D, Cullen, B, Cox, S R, Hayward, C, Porteous, D J, Evans, J, McIntosh, A M, Gallacher, J, Craddock, N, Pell, J P, Smith, D J, Gale, C R, Deary, I J

“…People’s differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA)…”
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Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity by Passini, Elisa, Britton, Oliver J, Lu, Hua Rong, Rohrbacher, Jutta, Hermans, An N, Gallacher, David J, Greig, Robert J H, Bueno-Orovio, Alfonso, Rodriguez, Blanca

“…Early prediction of cardiotoxicity is critical for drug development. Current animal models raise ethical and translational questions, and have limited accuracy…”
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Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology by Britton, Oliver J, Bueno-Orovio, Alfonso, Van Ammel, Karel, Lu, Hua Rong, Towart, Rob, Gallacher, David J, Rodriguez, Blanca

“…Cellular and ionic causes of variability in the electrophysiological activity of hearts from individuals of the same species are unknown. However, improved…”
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Using path signatures to predict a diagnosis of Alzheimer's disease by Moore, P J, Lyons, T J, Gallacher, J

“…The path signature is a means of feature generation that can encode nonlinear interactions in data in addition to the usual linear terms. It provides…”
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Monoenergetic beams of relativistic electrons from intense laser-plasma interactions by Mangles, S. P. D, Murphy, C. D, Najmudin, Z, Thomas, A. G. R, Collier, J. L, Dangor, A. E, Divall, E. J, Foster, P. S, Gallacher, J. G, Hooker, C. J, Jaroszynski, D. A, Langley, A. J, Mori, W. B, Norreys, P. A, Tsung, F. S, Viskup, R, Walton, B. R, Krushelnick, K

“…High-power lasers that fit into a university-scale laboratory can now reach focused intensities of more than 1019 W cm-2 at high repetition rates. Such lasers…”
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Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia by Hagenaars, S P, Harris, S E, Davies, G, Hill, W D, Liewald, D C M, Ritchie, S J, Marioni, R E, Fawns-Ritchie, C, Cullen, B, Malik, R, Worrall, B B, Sudlow, C L M, Wardlaw, J M, Gallacher, J, Pell, J, McIntosh, A M, Smith, D J, Gale, C R, Deary, I J

“…Causes of the well-documented association between low levels of cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health and…”
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The associations of socioeconomic status with incident dementia and Alzheimer’s disease are modified by leucocyte telomere length: a population-based cohort study by Lai, Ka Yan, Webster, Chris, Kumari, Sarika, Gallacher, John E. J., Sarkar, Chinmoy

“…Socio-economic status (SES) and biological aging are risk factors for dementia, including Alzheimer’s disease, however, it is less clear if the associations…”
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A compact synchrotron radiation source driven by a laser-plasma wakefield accelerator by Jaroszynski, D. A, Schlenvoigt, H.-P, Haupt, K, Debus, A, Budde, F, Jäckel, O, Pfotenhauer, S, Schwoerer, H, Rohwer, E, Gallacher, J. G, Brunetti, E, Shanks, R. P, Wiggins, S. M

“…Ultrashort light pulses are powerful tools for time-resolved studies of molecular and atomic dynamics. They arise in the visible and infrared range from…”
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Sleep disturbance and daytime sleepiness predict vascular dementia by Elwood, Peter C, Bayer, Antony J, Fish, Mark, Pickering, Janet, Mitchell, Clive, Gallacher, John E J

“…BackgroundDisturbed sleep is common throughout the community and is associated with an increase in daytime sleepiness, both of which, in turn are associated…”
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Cumulative life course adversity, mental health, and cognition in the UK biobank by Künzi, M., Gheorghe, D. A., Kliegel, M., Ballhausen, N., Gallacher, J., Bauermeister, S.

“…The association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains…”
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Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis by Olsen, J.R., Gallacher, J., Finlay, A.Y., Piguet, V., Francis, N.A.

“…Summary Background The Children's Dermatology Life Quality Index (CDLQI) is the most widely used instrument for measuring the impact of skin disease on quality…”
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Common respiratory conditions of the newborn by Gallacher, David J, Hart, Kylie, Kotecha, Sailesh

“…Respiratory distress is a common presenting feature among newborn infants.Prompt investigation to ascertain the underlying diagnosis and appropriate subsequent…”
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Impact of Treatments for Postmenopausal Osteoporosis (Bisphosphonates, Parathyroid Hormone, Strontium Ranelate, and Denosumab) on Bone Quality: A Systematic Review by Gallacher, S. J., Dixon, T.

“…The objective of this systematic review was to examine the influence of treatments for postmenopausal osteoporosis (parathyroid hormone [PTH], bisphosphonates,…”
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18F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis by Pugh, Dan, Patel, Dilip, Macnaught, Gillian, Czopek, Alicja, Bruce, Lorraine, Donachie, James, Gallacher, Peter J., Tan, Sovira, Ahlman, Mark, Grayson, Peter C., Basu, Neil, Dhaun, Neeraj

“…Disease-monitoring in large vessel vasculitis (LVV) is challenging. Simultaneous 18 F-fluorodeoxyglucose positron emission tomography with magnetic resonance…”
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Editorial: progress towards a simple tool for screening for hepatic steatosis in the general population by Gallacher, J., McPherson, S.

“…Linked ContentThis article is linked to Yip et al and Maj and Wong papers. To view these articles visit https://doi.org/10.1111/apt.14172 and…”
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High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds by Lu, Hua Rong, Whittaker, Ross, Price, Jeffrey H, Vega, Raquel, Pfeiffer, Emily R, Cerignoli, Fabio, Towart, Rob, Gallacher, David J

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are emerging as a powerful in vitro model for cardiac safety assessment which may allow…”
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Health status as a potential effect modifier of the relation between noise annoyance and incidence of ischaemic heart disease by Babisch, W, Ising, H, Gallacher, J E J

“…Aims: Traffic noise is a psychosocial stressor. Epidemiological studies suggest chronic noise stress to be a risk factor for cardiovascular disorders. Methods:…”
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Chronic drug‐induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell‐derived cardiomyocytes by Kopljar, Ivan, De Bondt, An, Vinken, Petra, Teisman, Ard, Damiano, Bruce, Goeminne, Nick, Van den Wyngaert, Ilse, Gallacher, David J, Lu, Hua Rong

“…Background and Purpose In the pharmaceutical industry risk assessments of chronic cardiac safety liabilities are mostly performed during late stages of…”
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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment by Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj

“…In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response,…”
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