Search Results - "GALE, M. JR"

Translational Control of Viral Gene Expression in Eukaryotes by GALE, M. JR, TAN, S.-L, KATZE, M. G

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Evolution of hepatitis C virus NS5A region in breakthrough patients during pegylated interferon and ribavirin therapy by Yuan, H. J., Jain, M., Snow, K. K., Gale Jr, M., Lee, W. M.

“…Investigating the evolution of the hepatitis C viral (HCV) genome in the small number of patients that experience viral breakthrough might shed light on the…”
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Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation by Gale, Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

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Translational control mediates the developmental regulation of the Trypanosoma brucei Nrk protein kinase by Gale, M, Carter, V, Parsons, M

“…The expression and function of eukaryotic protein kinases is highly regulated, primarily through transcriptional and post-translational processes. In this…”
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Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase by Gale, Jr, M, Kwieciszewski, B, Dossett, M, Nakao, H, Katze, M G

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Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway by Green, R.R., Wilkins, C., Pattabhi, S., Dong, R., Loo, Y., Gale, M.

“…The recognition of pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRR) during viral infection initiates the induction of…”
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Immune Signaling by RIG-I-like Receptors by Loo, Yueh-Ming, Gale, Michael

“…The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity…”
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Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein by Gale, Michael J., Korth, Marcus J., Tang, Norina M., Tan, Seng-Lai, Hopkins, Deborah A., Dever, Thomas E., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

“…Hepatitis C virus (HCV) is the major cause of non-A non-B hepatitis and a leading cause of liver dysfunction worldwide. While the current therapy for chronic…”
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Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease by Gall, Alevtina, Treuting, Piper, Elkon, Keith B., Loo, Yueh-Ming, Gale, Michael, Barber, Glen N., Stetson, Daniel B.

“…The type I interferon (IFN) response initiated by detection of nucleic acids is important for antiviral defense but is also associated with specific autoimmune…”
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Cell cycle-specific induction of an 89 kDa serine/threonine protein kinase activity in Trypanosoma brucei by GALE, M. JR, CARTER, V, PARSONS, M

“…The cell cycle compartmentalization of specific activities of the protozoan parasite Trypanosoma brucei has remained unexplored due to the lack of a cell…”
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A Trypanosoma brucei gene family encoding protein kinases with catalytic domains structurally related to Nek1 and NIMA by Gale, Jr, M, Parsons, M

“…Using polymerase chain reaction technology we cloned a Trypanosoma brucei gene fragment that has a deduced amino acid sequence with a high degree of homology…”
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Intracellular innate immune cascades and interferon defenses that control hepatitis C virus by Horner, Stacy M, Gale, Jr, Michael

“…Hepatitis C virus (HCV) is a global public health problem that mediates a persistent infection in nearly 200 million people. HCV is efficient in establishing…”
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Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease by Foy, Eileen, Li, Kui, Wang, Chunfu, Sumpter, Rhea, Ikeda, Masanori, Lemon, Stanley M., Gale, Michael

“…Persistent infections with hepatitis C virus (HCV) are likely to depend on viral inhibition of host defenses. We show that the HCV NS3/4A serine protease…”
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Disruption of Hepatitis C Virus RNA Replication through Inhibition of Host Protein Geranylgeranylation by Ye, Jin, Wang, Chunfu, Sumpter, Rhea, Brown, Michael S., Goldstein, Joseph L., Gale, Michael

“…Hepatitis C virus (HCV) RNA replication depends on viral protein association with intracellular membranes, but the influence of membrane composition on viral…”
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RIG-I like receptors in antiviral immunity and therapeutic applications by Ireton, Reneé C, Gale, Jr, Michael

“…The RNA helicase family of RIG-I-like receptors (RLRs) is a key component of host defense mechanisms responsible for detecting viruses and triggering innate…”
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Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein Kinase by Gale, Michael, Katze, Michael G

“…The interferon (IFN)-induced cellular antiviral response is the first line of defense against viral infection within an animal host. In order to establish a…”
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Interaction of the interferon-induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation by Gale, Michael, Tan, Seng-Lai, Wambach, Marlene, Katze, Michael G.

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Structural Basis of RNA Recognition and Activation by Innate Immune Receptor RIG-I by Jiang F., Ramanathan, A, Miller, M, Tang, G, Gale, Jr., M, Patel, S, Marcotrigiano, J

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Alpha Interferon Induces Distinct Translational Control Programs To Suppress Hepatitis C Virus RNA Replication by Wang, Chunfu, Pflugheber, Jill, Sumpter, Jr, Rhea, Sodora, Donald L, Hui, Daniel, Sen, Ganes C, Gale, Jr, Michael

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Viral evasion of the interferon system by Gale, Jr, Michael, Sen, Ganes C

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