Search Results - "GALBREATH, Elizabeth J"

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors by Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H., Andrews, Kristin L., Bartberger, Michael D., Van, Gwyneth, Galbreath, Elizabeth J., Vonderfecht, Steven L., Wang, Minghan, Jordan, Steven R., Véniant, Murielle M., Hale, Clarence

“…Two small-molecule disruptors of the glucokinase–glucokinase-regulatory-protein complex, AMG-1694 and AMG-3969, are identified that decrease blood glucose…”
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Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates by Chen, Nancy, Ehmann, David E., Crooker, Robert, Derakhchan, Katayoun, Fang, Xiaodong, Felice, Brian, Galbreath, Elizabeth J., Glaus, Charles, Gu, Hongbo, Huang, Yan, Li, Christine, Li, Xing, Liu, Nan, Palmieri, Kathleen, Simic, Damir, Sypek, Joseph, Thompson, Susan, Winkelmann, Christopher T., Choi, Vivian W.

“…Mucopolysaccharidosis II (MPS II) is a rare lysosomal storage disease characterized by deficient activity of iduronate-2-sulfatase (I2S), leading to…”
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Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response by Richardson, Mark A, Gupta, Akanksha, O'Brien, Lee A, Berg, David T, Gerlitz, Bruce, Syed, Samreen, Sharma, Ganesh R, Cramer, Martin S, Heuer, Josef G, Galbreath, Elizabeth J, Grinnell, Brian W

“…The protein C (PC) pathway plays an important role in vascular and immune function, and acquired deficiency during sepsis is associated with increased…”
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Toxicologic Neuropathology of Novel Biotherapeutics by Bangari, Dinesh S., Lanigan, Lisa G., Cramer, Sarah D., Grieves, Jessica L., Meisner, René, Rogers, Arlin B., Galbreath, Elizabeth J., Bolon, Brad

“…Biotherapeutic modalities such as cell therapies, gene therapies, nucleic acids, and proteins are increasingly investigated as disease-modifying treatments for…”
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Scientific and Regulatory Policy Committee Best Practices: Recommended (“Best”) Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies by Bolon, Brad, Francke, Sabine, Caverly Rae, Jessica M., Polack, Evelyne, Regan, Karen S., McInnes, Elizabeth F., Young, Jamie K., Keane, Kevin, Perry, Rick, Romeike, Annette, Colman, Karyn, Jensen, Karl, Nakano-Ito, Kyoko, Galbreath, Elizabeth J.

“…This article describes the Society of Toxicologic Pathology’s (STP) five recommended (“best”) practices for appropriate use of informed (non-blinded) versus…”
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FGF-21 as a novel metabolic regulator by Kharitonenkov, Alexei, Shiyanova, Tatiyana L, Koester, Anja, Ford, Amy M, Micanovic, Radmila, Galbreath, Elizabeth J, Sandusky, George E, Hammond, Lisa J, Moyers, Julie S, Owens, Rebecca A, Gromada, Jesper, Brozinick, Joseph T, Hawkins, Eric D, Wroblewski, Victor J, Li, De-Shan, Mehrbod, Farrokh, Jaskunas, S Richard, Shanafelt, Armen B

“…Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here we describe a potential novel therapeutic agent for this disease,…”
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Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing by Bennet, Bindu M., Pardo, Ingrid D., Assaf, Basel T., Buza, Elizabeth, Cramer, Sarah D., Crawford, LaTasha K., Engelhardt, Jeffery A., Galbreath, Elizabeth J., Grubor, Branka, Morrison, James P., Osborne, Tanasa S., Sharma, Alok K., Bolon, Brad

“…Dorsal root ganglia (DRG), trigeminal ganglia (TG), other sensory ganglia, and autonomic ganglia may be injured by some test article classes, including…”
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Porcine circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice by Kiupel, Matti, Stevenson, Gregory W, Galbreath, Elizabeth J, North, Adam, HogenEsch, Harm, Mittal, Suresh K

“…We have previously described microscopic and electron microscopic alterations in lymphoid organs of PCV2 inoculated mice as apoptosis. In this study we wanted…”
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Opinion on Current Use of Non-Blinded Versus Blinded Histopathologic Evaluation in Animal Toxicity Studies by Bolon, Brad, Caverly Rae, Jessica M., Colman, Karyn, Francke, Sabine, Jensen, Karl, Keane, Kevin, McInnes, Elizabeth F., Nakano-Ito, Kyoko, Perry, Rick, Polack, Evelyne, Regan, Karen S., Romeike, Annette, Young, Jamie K., Galbreath, Elizabeth J.

“…The Society of Toxicologic Pathology (STP) explored current institutional practices for selecting between non-blinded versus blinded histopathologic evaluation…”
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Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor by Searfoss, George H., Jordan, William H., Calligaro, David O., Galbreath, Elizabeth J., Schirtzinger, Linda M., Berridge, Brian R., Gao, Hong, Higgins, Marnie A., May, Patrick C., Ryan, Timothy P.

“…Functional γ-secretase inhibitors (FGSIs) can block the cleavage of several transmembrane proteins including amyloid precursor protein (APP), and the cell fate…”
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Use of Tissue Cross-reactivity Studies in the Development of Antibody-based Biopharmaceuticals: History, Experience, Methodology, and Future Directions by Leach, Michael W., Halpern, Wendy G., Johnson, Carol W., Rojko, Jennifer L., MacLachlan, Tim K., Chan, Curtis M., Galbreath, Elizabeth J., Ndifor, Anthony M., Blanset, Diann L., Polack, Evelyne, Cavagnaro, Joy A.

“…Tissue cross-reactivity (TCR) studies are screening assays recommended for antibody and antibody-like molecules that contain a complementarity-determining…”
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Properties of Bisphosphonates in the 13762 Rat Mammary Carcinoma Model of Tumor-Induced Bone Resorption by ALVAREZ, Enrique, WESTMORE, Michael, ZAMBRANO, Carmen, MA, Linda, SATO, Masahiko, MARTIN, T. John, TEICHER, Beverly A, GALBREATH, Elizabeth J, SELLS GALVIN, Rachelle J, CLAPP, Crystal L, CONSIDINE, Eileen L, SMITH, Shawn J, KEYES, Kristan, IVERSEN, Philip W, DELAFUENTE, Dawn M, SULAIMON, Shola

“…Bone metastasis from primary tumors is a clinically important complication of neoplastic progression. The role of parathyroid hormone-related protein (PTHrP)…”
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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia by Dubus, Pierre, Mettus, Richard V, Boden, Guenther, Rane, Sushil G, Galbreath, Elizabeth J, Barbacid, Mariano, Reddy, E. Premkumar

“…To ascertain the role of cyclin-dependent kinase 4 (Cdk4) in vivo, we have targeted the mouse Cdk4 locus by homologous recombination to generate two strains of…”
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Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury by GUPTA, Akanksha, GERLITZ, Bruce, RICHARDSON, Mark A, BULL, Christopher, BERG, David T, SYED, Samreen, GALBREATH, Elizabeth J, SWANSON, Barbara A, JONES, Bryan E, GRINNELL, Brian W

“…Administration of activated protein C (APC) protects from renal dysfunction, but the underlying mechanism is unknown. APC exerts both antithrombotic and…”
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Role of protein C in renal dysfunction after polymicrobial sepsis by GUPTA, Akanksha, BERG, David T, GERLITZ, Bruce, SHARMA, Ganesh R, SYED, Samreen, RICHARDSON, Mark A, SANDUSKY, George, HEUER, Josef G, GALBREATH, Elizabeth J, GRINNELL, Brian W

“…Protein C (PC) plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased mortality in both animal models…”
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Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice by Messing, A, Head, MW, Galles, K, Galbreath, EJ, Goldman, JE, Brenner, M

“…Increased expression of glial fibrillary acidic protein (GFAP) is a hallmark of gliosis, the astrocytic hypertrophy that occurs during a wide variety of…”
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Activated protein C modulates chemokine response and tissue injury in experimental sepsis by Sharma, Ganesh R, Gerlitz, Bruce, Berg, David T, Cramer, Martin S, Jakubowski, Joseph A, Galbreath, Elizabeth J, Heuer, Josef G, Grinnell, Brian W

“…The protein C (PC) pathway plays an important role in vascular function, and acquired deficiency during sepsis is associated with increased mortality. We have…”
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Disease pathology in the iduronate-2-sulfatase KO mouse: Opportunities for novel endpoints for second generation enzyme replacement strategies by Modi, Meera E., Derakhchan, Katayoun, Winkelmann, Christopher T., Galbreath, Elizabeth J., Ehmann, David E.

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OVEREXPRESSION OF GFAP IN TRANSGENIC MICE by Messing, Albee, Galbreath, Elizabeth J, Sijapati, Karuna K, Brenner, Michael

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Peripheral neuroblastoma in a dog by Forrest, L.J, Galbreath, E.J, Dubielzig, R.R, MacEwen, E.G

“…Primitive neuroectodermal tumors are composed of primitive neuroepithelial cells and include tumors of the central and peripheral nervous system…”
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