Search Results - "GAGNEUX, S"

Fitness cost of drug resistance in Mycobacterium tuberculosis by Gagneux, S.

“…Multidrug‐resistant (MDR) ‐ and extensively drug‐resistant (XDR) ‐ forms of tuberculosis are growing public health problems. Mathematical models predict that…”
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Infectiousness, reproductive fitness and evolution of drug-resistant Mycobacterium tuberculosis [State of the art] by BORRELL, S, GAGNEUX, S

“…Mathematical models predict that the future of the multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) epidemic will depend to a…”
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Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission by VOS, M. De, MÜLLER, B, BORRELL, S, BLACK, P. A, HELDEN, P. D. Van, WARREN, R. M, GAGNEUX, S, VICTOR, T. C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis by Borrell, S., Gagneux, S.

“…Mycobacterium tuberculosis harbours little DNA sequence diversity compared with other bacteria. However, there is mounting evidence that strain-to-strain…”
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Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis by Nahid, P, Jarlsberg, L G, Kato-Maeda, M, Segal, M R, Osmond, D H, Gagneux, S, Dobos, K, Gold, M, Hopewell, P C, Lewinsohn, D M

“…The roles of host and pathogen factors in determining innate immune responses to M. tuberculosis are not fully understood. In this study, we examined host…”
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Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria by Andre, E., Goeminne, L., Cabibbe, A., Beckert, P., Kabamba Mukadi, B., Mathys, V., Gagneux, S., Niemann, S., Van Ingen, J., Cambau, E.

“…The rpoB gene codes for the RNA polymerase β subunit, which is the target of rifampicin, an essential drug in the treatment of tuberculosis and other…”
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Clinical implications of molecular drug resistance testing for Mycobacterium tuberculosis: a TBNET/RESIST-TB consensus statement by Domínguez, J., Boettger, E. C., Cirillo, D., Cobelens, F., Eisenach, K. D., Gagneux, S., Hillemann, D., Horsburgh, R., Molina-Moya, B., Niemann, S., Tortoli, E., Whitelaw, A., Lange, C., for the TBNET and RESIST-TB networks

“…The emergence of drug-resistant strains of Mycobacterium tuberculosis is a challenge to global tuberculosis (TB) control. Although culture-based methods have…”
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Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex by Chiner-Oms, Á, Sánchez-Busó, L, Corander, J, Gagneux, S, Harris, S R, Young, D, González-Candelas, F, Comas, I

“…Models on how bacterial lineages differentiate increase our understanding of early bacterial speciation events and the genetic loci involved. Here, we analyze…”
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Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study by Mhimbira, F., Hiza, H., Mbuba, E., Hella, J., Kamwela, L., Sasamalo, M., Ticlla, M., Said, K., Mhalu, G., Chiryamkubi, M., Schindler, C., Reither, K., Gagneux, S., Fenner, L.

“…To describe the prevalence of respiratory pathogens in tuberculosis (TB) patients and in their household contact controls, and to determine the clinical…”
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Detection and characterization of drug-resistant conferring genes in Mycobacterium tuberculosis complex strains: A prospective study in two distant regions of Ghana by Otchere, I.D, Asante-Poku, A, Osei-Wusu, S, Baddoo, A, Sarpong, E, Ganiyu, A.H, Aboagye, S.Y, Forson, A, Bonsu, F, Yahayah, A.I, Koram, K, Gagneux, S, Yeboah-Manu, D

“…Summary We spoligotyped and screened 1490 clinical Mycobacterium tuberculosis complex strains from Northern and Greater Accra regions of Ghana against INH and…”
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Evaluation of GenoType® MTBDRplus for the rapid detection of drug-resistant tuberculosis in Ghana by Asante-Poku, A., Otchere, I. D., Danso, E., Mensah, D. D., Bonsu, F., Gagneux, S., Yeboah-Manu, D.

“…BACKGROUND: Rapid but simple diagnostic tools for the detection of drug-resistant (DR) tuberculosis (TB) have been acknowledged as being important for its…”
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Strain classification of Mycobacterium tuberculosis: congruence between large sequence polymorphisms and spoligotypes [Short communication] by KATO-MAEDA, M, GAGNEUX, S, FLORES, L. L, KIM, E. Y, SMALL, P. M, DESMOND, E. P, HOPEWELL, P. C

“…Spoligotyping is used in molecular epidemiological studies, and signature patterns have identified strain families. However, homoplasy occurs in the markers…”
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Genetic diversity of Mycobacterium tuberculosis in Madang, Papua New Guinea by Ballif, M., Harino, P., Ley, S., Carter, R., Coulter, C., Niemann, S., Borrell, S., Fenner, L., Siba, P., Phuanukoonnon, S., Gagneux, S., Beck, H-P.

“…SETTING: Madang and surroundings, Papua New Guinea (PNG).OBJECTIVE: To characterise the genetic diversity and drug susceptibility of Mycobacterium tuberculosis…”
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Prospective Study of a Serogroup X Neisseria meningitidis Outbreak in Northern Ghana by Gagneux, Sébastien P., Hodgson, Abraham, Smith, Tom A., Wirth, Thierry, Ehrhard, Ingrid, Morelli, Giovanna, Genton, Blaise, Binka, Fred N., Achtman, Mark, Pluschke, Gerd

“…After an epidemic of serogroup A meningococcal meningitis in northern Ghana, a gradual disappearance of the epidemic strain was observed in a series of five…”
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 by Blondiaux, Nicolas, Moune, Martin, Desroses, Matthieu, Frita, Rosangela, Flipo, Marion, Mathys, Vanessa, Soetaert, Karine, Kiass, Mehdi, Delorme, Vincent, Djaout, Kamel, Trebosc, Vincent, Kemmer, Christian, Wintjens, René, Wohlkönig, Alexandre, Antoine, Rudy, Huot, Ludovic, Hot, David, Coscolla, Mireia, Feldmann, Julia, Gagneux, Sebastien, Locht, Camille, Brodin, Priscille, Gitzinger, Marc, Déprez, Benoit, Willand, Nicolas, Baulard, Alain R.

“…Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium…”
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Fitness cost of drug resistance in Mycobacterium tuberculosis: Environmental changes, microbial systems and infections by GAGNEUX, S

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Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis : Tuberculosis: an unpredictable long-standing human companion still in need of rapid diagnostic tests by BORRELL, S, GAGNEUX, S

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Variable Host-Pathogen Compatibility in Mycobacterium tuberculosis by Gagneux, Sebastien, DeRiemer, Kathryn, Van, Tran, Kato-Maeda, Midori, de Jong, Bouke C., Narayanan, Sujatha, Nicol, Mark, Niemann, Stefan, Kremer, Kristin, Gutierrez, M. Cristina, Hilty, Markus, Hopewell, Philip C., Small, Peter M.

“…Mycobacterium tuberculosis remains a major cause of morbidity and mortality worldwide. Studies have reported human pathogens to have geographically structured…”
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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase by Ezewudo, Matthew, Borens, Amanda, Chiner-Oms, Álvaro, Miotto, Paolo, Chindelevitch, Leonid, Starks, Angela M., Hanna, Debra, Liwski, Richard, Zignol, Matteo, Gilpin, Christopher, Niemann, Stefan, Kohl, Thomas Andreas, Warren, Robin M., Crook, Derrick, Gagneux, Sebastien, Hoffner, Sven, Rodrigues, Camilla, Comas, Iñaki, Engelthaler, David M., Alland, David, Rigouts, Leen, Lange, Christoph, Dheda, Keertan, Hasan, Rumina, McNerney, Ruth, Cirillo, Daniela M., Schito, Marco, Rodwell, Timothy C., Posey, James

“…Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize…”
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Drug susceptibility testing and mortality in patients treated for tuberculosis in high-burden countries: a multicentre cohort study: Lancet Infect Dis by Zurcher, K., Ballif, M., Fenner, L., Borrell, S., Keller, P. M., Gnokoro, J., Marcy, Olivier, Yotebieng, M., Diero, L., Carter, E. J., Rockwood, N., Wilkinson, R. J., Cox, H., Ezati, N., Abimiku, A. G., Collantes, J., Avihingsanon, A., Kawkitinarong, K., Reinhard, M., Homke, R., Huebner, R., Gagneux, S., Bottger, E. C., Egger, M.

“…BACKGROUND: Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden…”
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