Search Results - "GAGLIANI, Nicola"

CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression by Schneider, Enja, Winzer, Riekje, Rissiek, Anne, Ricklefs, Isabell, Meyer-Schwesinger, Catherine, Ricklefs, Franz L., Bauche, Andreas, Behrends, Jochen, Reimer, Rudolph, Brenna, Santra, Wasielewski, Hauke, Lauten, Melchior, Rissiek, Björn, Puig, Berta, Cortesi, Filippo, Magnus, Tim, Fliegert, Ralf, Müller, Christa E., Gagliani, Nicola, Tolosa, Eva

“…Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control…”
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Functional heterogeneity of CD4+ T cells in liver inflammation by Muscate, Franziska, Woestemeier, Anna, Gagliani, Nicola

“…CD4 + T cells play an essential role in orchestrating adequate immunity, but their overactivity has been associated with the development of immune-mediated…”
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IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo by Brockmann, Leonie, Gagliani, Nicola, Steglich, Babett, Giannou, Anastasios D, Kempski, Jan, Pelczar, Penelope, Geffken, Maria, Mfarrej, Bechara, Huber, Francis, Herkel, Johannes, Wan, Yisong Y, Esplugues, Enric, Battaglia, Manuela, Krebs, Christian F, Flavell, Richard A, Huber, Samuel

“…IL-10 is essential to maintain intestinal homeostasis. CD4 T regulatory type 1 (T 1) cells produce large amounts of this cytokine and are therefore currently…”
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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis by Nowarski, Roni, Jackson, Ruaidhrí, Gagliani, Nicola, de Zoete, Marcel R., Palm, Noah W., Bailis, Will, Low, Jun Siong, Harman, Christian C.D., Graham, Morven, Elinav, Eran, Flavell, Richard A.

“…The intestinal mucosal barrier controlling the resident microbiome is dependent on a protective mucus layer generated by goblet cells, impairment of which is a…”
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The induction and function of the anti-inflammatory fate of TH17 cells by Xu, Hao, Agalioti, Theodora, Zhao, Jun, Steglich, Babett, Wahib, Ramez, Vesely, Maria Carolina Amezcua, Bielecki, Piotr, Bailis, Will, Jackson, Ruaidhri, Perez, Daniel, Izbicki, Jakob, Licona-Limón, Paula, Kaartinen, Vesa, Geginat, Jens, Esplugues, Enric, Tolosa, Eva, Huber, Samuel, Flavell, Richard A., Gagliani, Nicola

“…T H 17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the…”
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Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis by Brockmann, Leonie, Giannou, Anastasios, Gagliani, Nicola, Huber, Samuel

“…Wound healing is a crucial process which protects our body against permanent damage and invasive infectious agents. Upon tissue damage, inflammation is an…”
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IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine by Huber, Samuel, Gagliani, Nicola, Zenewicz, Lauren A., Huber, Francis J., Bosurgi, Lidia, Hu, Bo, Hedl, Matija, Zhang, Wei, O’Connor, William, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George D., Booth, Carmen J., Cho, Judy H., Ouyang, Wenjun, Abraham, Clara, Flavell, Richard A.

“…IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via…”
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Conserved transcriptomic profile between mouse and human colitis allows unsupervised patient stratification by Czarnewski, Paulo, Parigi, Sara M., Sorini, Chiara, Diaz, Oscar E., Das, Srustidhar, Gagliani, Nicola, Villablanca, Eduardo J.

“…Clinical manifestations and response to therapies in ulcerative colitis (UC) are heterogeneous, yet patient classification criteria for tailored therapies are…”
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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer by Perez, Laura Garcia, Kempski, Jan, McGee, Heather M., Pelzcar, Penelope, Agalioti, Theodora, Giannou, Anastasios, Konczalla, Leonie, Brockmann, Leonie, Wahib, Ramez, Xu, Hao, Vesely, Maria Carolina Amezcua, Soukou, Shiwa, Steglich, Babett, Bedke, Tanja, Manthey, Carolin, Seiz, Oliver, Diercks, Björn-Philipp, Gnafakis, Stylianos, Guse, Andreas H., Perez, Daniel, Izbicki, Jakob R., Gagliani, Nicola, Flavell, Richard A., Huber, Samuel

“…IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes…”
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Roles of microbiota in pancreatic cancer development and treatment by Cruz, Mariana Santos, Tintelnot, Joseph, Gagliani, Nicola

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced…”
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Control of TH17 cells occurs in the small intestine by Esplugues, Enric, Huber, Samuel, Gagliani, Nicola, Hauser, Anja E., Town, Terrence, Wan, Yisong Y., O’Connor, William, Rongvaux, Anthony, Van Rooijen, Nico, Haberman, Ann M., Iwakura, Yoichiro, Kuchroo, Vijay K., Kolls, Jay K., Bluestone, Jeffrey A., Herold, Kevan C., Flavell, Richard A.

“…Keeping T H 17 cells under wraps Interleukin-17-producing T helper (T H 17) cells serve an important role in the immune system, but are strongly implicated in…”
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DISCERN: deep single-cell expression reconstruction for improved cell clustering and cell subtype and state detection by Hausmann, Fabian, Ergen, Can, Khatri, Robin, Marouf, Mohamed, Hänzelmann, Sonja, Gagliani, Nicola, Huber, Samuel, Machart, Pierre, Bonn, Stefan

“…Abstract Background Single-cell sequencing provides detailed insights into biological processes including cell differentiation and identity. While providing…”
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The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer by Geginat, Jens, Larghi, Paola, Paroni, Moira, Nizzoli, Giulia, Penatti, Alessandra, Pagani, Massimiliano, Gagliani, Nicola, Meroni, Pierluigi, Abrignani, Sergio, Flavell, Richard A

“…Highlights • IL-10 produced by regulatory T-cells has a non-redundant role to maintain intestinal immune homeostasis and to prevent colitis. • IL-10 produced…”
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Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney by Krebs, Christian F., Paust, Hans-Joachim, Krohn, Sonja, Koyro, Tobias, Brix, Silke R., Riedel, Jan-Hendrik, Bartsch, Patricia, Wiech, Thorsten, Meyer-Schwesinger, Catherine, Huang, Jiabin, Fischer, Nicole, Busch, Philipp, Mittrücker, Hans-Willi, Steinhoff, Ulrich, Stockinger, Brigitta, Perez, Laura Garcia, Wenzel, Ulrich O., Janneck, Matthias, Steinmetz, Oliver M., Gagliani, Nicola, Stahl, Rolf A.K., Huber, Samuel, Turner, Jan-Eric, Panzer, Ulf

“…Th17 cells are most abundant in the gut, where their presence depends on the intestinal microbiota. Here, we examined whether intestinal Th17 cells contribute…”
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The spatial transcriptomic landscape of the healing mouse intestine following damage by Parigi, Sara M., Larsson, Ludvig, Das, Srustidhar, Ramirez Flores, Ricardo O., Frede, Annika, Tripathi, Kumar P., Diaz, Oscar E., Selin, Katja, Morales, Rodrigo A., Luo, Xinxin, Monasterio, Gustavo, Engblom, Camilla, Gagliani, Nicola, Saez-Rodriguez, Julio, Lundeberg, Joakim, Villablanca, Eduardo J.

“…The intestinal barrier is composed of a complex cell network defining highly compartmentalized and specialized structures. Here, we use spatial transcriptomics…”
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Purinergic enzymes on extracellular vesicles: immune modulation on the go by Winzer, Riekje, Nguyen, Du Hanh, Schoppmeier, Felix, Cortesi, Filippo, Gagliani, Nicola, Tolosa, Eva

“…An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent…”
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Commensal Bacteria-Specific CD4 + T Cell Responses in Health and Disease by Sorini, Chiara, Cardoso, Rebeca F, Gagliani, Nicola, Villablanca, Eduardo J

“…Over the course of evolution, mammalian body surfaces have adapted their complex immune system to allow a harmless coexistence with the commensal microbiota…”
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Life, death, and miracles: Th17 cells in the intestine by Huber, Samuel, Gagliani, Nicola, Flavell, Richard A.

“…Th17 cells, a distinct subset of CD4+ T‐helper cells, are commonly associated with chronic inflammatory and autoimmune diseases; however, Th17 cells also…”
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Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza by Hartmann, Wiebke, Brunn, Marie-Luise, Stetter, Nadine, Gagliani, Nicola, Muscate, Franziska, Stanelle-Bertram, Stephanie, Gabriel, Gülsah, Breloer, Minka

“…Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we…”
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MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis by Pan, Wen, Zhu, Shu, Dai, Dai, Liu, Zheng, Li, Dan, Li, Bin, Gagliani, Nicola, Zheng, Yunjiang, Tang, Yuanjia, Weirauch, Matthew T., Chen, Xiaoting, Zhu, Wei, Wang, Yue, Chen, Bo, Qian, Youcun, Chen, Yingxuan, Fang, Jingyuan, Herbst, Ronald, Richman, Laura, Jallal, Bahija, Harley, John B., Flavell, Richard A., Yao, Yihong, Shen, Nan

“…Although different autoimmune diseases show discrete clinical features, there are common molecular pathways intimately involved. Here we show that miR-125a is…”
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