Search Results - "GABRILOVICH, D. I"

Decreased antigen presentation by dendritic cells in patients with breast cancer by GABRILOVICH, D. I, CORAK, J, CIERNIK, I. F, KAVANAUGH, D, CARBONE, D. P

“…We evaluated T-cell responses to mitogens and to defined antigens in breast cancer patients. Significant defects in responses to tetanus toxoid and influenza…”
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Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer by Almand, Bond, Clark, Joseph I, Nikitina, Ekaterina, van Beynen, James, English, Nicholas R, Knight, Stella C, Carbone, David P, Gabrilovich, Dmitry I

“…Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control…”
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Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells by Gabrilovich, Dmitry I, Velders, Markwin P, Sotomayor, Eduardo M, Kast, W. Martin

“…The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of tumor immunology. Development of T cell defects in tumor-bearing hosts…”
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Antibodies to Vascular Endothelial Growth Factor Enhance the Efficacy of Cancer Immunotherapy by Improving Endogenous Dendritic Cell Function by GABRILOVICH, D. I, ISHIDA, T, NADAF, S, OHM, J. E, CARBONE, D. P

“…Inadequate function of dendritic cells (DCs) in tumor-bearing hosts is one mechanism of tumor escape from immune system control and may compromise the efficacy…”
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An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53 by NIKITINA, E. Y, CHADA, S, MURO-CACHO, C, FANG, B, ZHANG, R, ROTH, J. A, GABRILOVICH, D. I

“…P53-based immunization is an attractive approach to cancer immunotherapy due to the accumulation of p53 protein in tumor, but not in normal cells. However, it…”
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Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death by Kagan, V.E., Tyurina, Y.Y., Sun, W.Y., Vlasova, I.I., Dar, H., Tyurin, V.A., Amoscato, A.A., Mallampalli, R., van der Wel, P.C.A., He, R.R., Shvedova, A.A., Gabrilovich, D.I., Bayir, H.

“…High fidelity and effective adaptive changes of the cell and tissue metabolism to changing environments require strict coordination of numerous biological…”
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Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells by Lisziewicz, J, Gabrilovich, D I, Varga, G, Xu, J, Greenberg, P D, Arya, S K, Bosch, M, Behr, J P, Lori, F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dendritic cells transduced with wild‐type p53 gene elicit potent anti‐tumour immune responses by ISHIDA, T, CHADA, S, STIPANOV, M, NADAF, S, CIERNIK, F. I, GABRILOVICH, D. I, CARBONE, D. P

“…In this study we have tested the concept of using wild‐type p53 gene for immunotherapy of cancer. Dendritic cells (DC) were transduced with a human wild‐type…”
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Clinical Significance of Defective Dendritic Cell Differentiation in Cancer by Almand, B, Resser, J R, Lindman, B, Nadaf, S, Clark, J I, Kwon, E D, Carbone, D P, Gabrilovich, D I

“…Defective dendritic cell (DC) function has been described previously in cancer patients and tumor-bearing mice. It can be an important factor in the escape of…”
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Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells by Oyama, T, Ran, S, Ishida, T, Nadaf, S, Kerr, L, Carbone, D P, Gabrilovich, D I

“…Vascular endothelial growth factor (VEGF), produced by almost all tumor cells, affects the ability of hemopoietic progenitor cells (HPC) to differentiate into…”
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Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells by Gabrilovich, Dmitry I, Chen, Hailei L, Girgis, Khaled R, Cunningham, H. Thomas, Meny, Geralyn M, Nadaf, Sorena, Kavanaugh, Denise, Carbone, David P

“…Inadequate presentation of tumor antigens by host professional antigen-presenting cells (APCs), including dendritic cells (DCs), is one potential mechanism for…”
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Combination of γ‐irradiation and dendritic cell administration induces a potent antitumor response in tumor‐bearing mice: Approach to treatment of advanced stage cancer by Nikitina, Ekaterina Yu, Gabrilovich, Dmitry I.

“…We investigated a new approach to the treatment of advanced stage cancer, a combination of apoptosis‐inducing therapy and dendritic cell (DC) administration…”
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IL-12 and mutant P53 peptide-pulsed dendritic cells for the specific immunotherapy of cancer by Gabrilovich, D I, Cunningham, H T, Carbone, D P

“…Mice bearing palpable tumors expressing a mutant p53 gene were treated with intravenous injection of mutant p53-specific peptide-pulsed dendritic cells (DCs)…”
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Retrovirus-induced immunosuppression via blocking of dendritic cell migration and down-regulation of adhesion molecules by Gabrilovich, D I, Woods, G M, Patterson, S, Harvey, J J, Knight, S C

“…Dendritic cells (DC) within tissues may acquire and process antigens, carry them into lymph nodes and cluster and activate T cells. The ability of DC to…”
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Dendritic Cells in Antitumor Immune Responses: I. Defective Antigen Presentation in Tumor-Bearing Hosts by Gabrilovich, Dmitry I., Ciernik, I.Frank, Carbone, David P.

“…Induction of specific antitumor cytotoxic T cell responses was studied in BALB/c mice bearing tumors transfected with a mutant human p53 minigene. We observed…”
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Defective Function of Langerhans Cells in Tumor-Bearing Animals Is the Result of Defective Maturation from Hemopoietic Progenitors by Ishida, Tadao, Oyama, Tsunehiro, Carbone, David P, Gabrilovich, Dmitry I

“…Langerhans cells (LC), the APCs in the skin, serve as a model for investigation of dendritic cell (DC) function in tissues. DC play a crucial role in the…”
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Dendritic Cells in Antitumor Immune Responses: II. Dendritic Cells Grown from Bone Marrow Precursors, but Not Mature DC from Tumor-Bearing Mice, Are Effective Antigen Carriers in the Therapy of Established Tumors by Gabrilovich, Dmitry I., Nadaf, Sorena, Corak, Jadranko, Berzofsky, Jay A., Carbone, David P.

“…Antitumor CTL responses were studied in a model tumor bearing a mutant human p53 gene. We found ineffective induction of antitumor CTL in mice bearing these…”
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Effect of Vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation In Vivo by Ohm, Joyce E, Shurin, Michael R, Esche, Clemens, Lotze, Michael T, Carbone, David P, Gabrilovich, Dmitry I

“…The cytokine FLT3 ligand (FL) enhances dendritic cell (DC) generation and has therefore been proposed as a means to boost antitumor immunity. Vascular…”
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Dendritic Cells Transduced with Full-Length Wild-Type p53 Generate Antitumor Cytotoxic T Lymphocytes from Peripheral Blood of Cancer Patients by NIKITINA, Ekaterina Yu, CLARK, Joseph I, VAN BEYNEN, James, CHADA, Sunil, VIRMANI, Arvind K, CARBONE, David P, GABRILOVICH, Dmitry I

“…Accumulation of wild-type or mutant p53 protein occurs in ∼50% of human malignancies. This overexpression may generate antigenic epitopes recognized by CTLs…”
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An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53 by Nikitina, E Y, Chada, S, Muro-Cacho, C, Fang, B, Zhang, R, Roth, JA, Gabrilovich, DI

“…P53-based immunization is an attractive approach to cancer immunotherapy due to the accumulation of p53 protein in tumor, but not in normal cells. However, it…”
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