Search Results - "G. Johan A. Offerhaus"

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening by Driehuis, Else, van Hoeck, Arne, Moore, Kat, Kolders, Sigrid, Francies, Hayley E., Gulersonmez, M. Can, Stigter, Edwin C. A., Burgering, Boudewijn, Geurts, Veerle, Gracanin, Ana, Bounova, Gergana, Morsink, Folkert H., Vries, Robert, Boj, Sylvia, van Es, Johan, Offerhaus, G. Johan A., Kranenburg, Onno, Garnett, Mathew J., Wessels, Lodewyk, Cuppen, Edwin, Brosens, Lodewijk A. A., Clevers, Hans

“…We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor…”
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A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas by Basturk, Olca, Hong, Seung-Mo, Wood, Laura D, Adsay, N Volkan, Albores-Saavedra, Jorge, Biankin, Andrew V, Brosens, Lodewijk A.A, Fukushima, Noriyoshi, Goggins, Michael, Hruban, Ralph H, Kato, Yo, Klimstra, David S, Klöppel, Günter, Krasinskas, Alyssa, Longnecker, Daniel S, Matthaei, Hanno, Offerhaus, G. Johan A, Shimizu, Michio, Takaori, Kyoichi, Terris, Benoit, Yachida, Shinichi, Esposito, Irene, Furukawa, Toru

“…International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive…”
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Degree and site of chromosomal instability define its oncogenic potential by Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette

“…Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy…”
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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma by Cai, Jianqiang, Torbenson, Michael S, Kinzler, Kenneth W, Li, Meng, Zhao, Hong, Zhang, Xiaosong, Wood, Laura D, Anders, Robert A, Choti, Michael A, Pawlik, Timothy M, Daniel, Hubert D, Kannangai, Rajesh, Offerhaus, G Johan A, Velculescu, Victor E, Wang, Linfang, Zhou, Shibin, Vogelstein, Bert, Hruban, Ralph H, Papadopoulos, Nick

“…Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected…”
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Loss of SMAD4 Alters BMP Signaling to Promote Colorectal Cancer Cell Metastasis via Activation of Rho and ROCK by Voorneveld, Philip W, Kodach, Liudmila L, Jacobs, Rutger J, Liv, Nalan, Zonnevylle, A. Christiaan, Hoogenboom, Jacob P, Biemond, Izak, Verspaget, Hein W, Hommes, Daniel W, de Rooij, Karien, van Noesel, Carel J.M, Morreau, Hans, van Wezel, Tom, Offerhaus, G. Johan A, van den Brink, Gijs R, Peppelenbosch, Maikel P, ten Dijke, Peter, Hardwick, James C.H

“…Background & Aims SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4…”
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Molecular alterations in gastric cancer with special reference to the early-onset subtype by Skierucha, Małgorzata, Milne, Anya Na, Offerhaus, G Johan A, Polkowski, Wojciech P, Maciejewski, Ryszard, Sitarz, Robert

“…Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause…”
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BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2 by Kestens, Christine, Siersema, Peter D, Offerhaus, G Johan A, van Baal, Jantine W P M

“…Bone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett's esophagus (BE), a precursor of esophageal adenocarcinoma (EAC). In…”
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Classification of types of intraductal papillary-mucinous neoplasm of the pancreas : a consensus study by FURUKAWA, Toru, KLÖPPEL, Günter, LÜTTGES, Jutta, OFFERHAUS, G. Johan A, SHIMIZU, Michio, SUNAMURA, Makoto, SURIAWINATA, Arief, TAKAORI, Kyoichi, YONEZAWA, Suguru, ADSAY, N. Volkan, ALBORES-SAAVEDRA, Jorge, FUKUSHIMA, Noriyoshi, HORII, Akira, HRUBAN, Ralph H, KATO, Yo, KLIMSTRA, David S, LONGNECKER, Daniel S

“…Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists…”
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De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine by Haramis, Anna-Pavlina G., Begthel, Harry, van den Born, Maaike, van Es, Johan, Jonkheer, Suzanne, G. Johan A. Offerhaus, Clevers, Hans

“…Little is known about the signaling mechanisms that determine the highly regular patterning of the intestinal epithelium into crypts and villi. With the use of…”
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Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome by HEARLE, Nicholas, SCHUMACHER, Valerie, TRIMBATH, Jill D, GIARDIELLO, Francis M, GRUBER, Stephen B, OFFERHAUS, G. Johan A, DE ROOIJ, Felix W. M, WILSON, J. H. Paul, HANSMANN, Anika, MÖSLEIN, Gabriela, ROYER-POKORA, Brigitte, TILMANVOGEL, MENKO, Fred H, PHILLIPS, Robin K. S, SPIGELMAN, Allan D, HOULSTON, Richard S, OLSCHWANG, Sylviane, BOARDMAN, Lisa A, GILLE, Johan J. P, KELLER, Josbert J, WESTERMAN, Anne Marie, SCOTT, Rodney J, LIM, Wendy

“…Background: Although an increased cancer risk in Peutz-Jeghers syndrome is established, data on the spectrum of tumors associated with the disease and the…”
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Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation by Vasen, Hans F.A, Wasser, Martin, van Mil, Anneke, Tollenaar, Rob A, Konstantinovski, Marja, Gruis, Nelleke A, Bergman, Wilma, Hes, Frederik J, Hommes, Daniel W, Offerhaus, G. Johan A, Morreau, Hans, Bonsing, Bert A, de Vos tot Nederveen Cappel, Wouter H

“…Background & Aims Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline…”
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An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms by HRUBAN, Ralph H, TAKAORI, Kyoichi, GOGGINS, Michael, KATO, Yo, KLÖPPEL, Gunter, LONGNECKER, Daniel S, LUNGES, Jutta, MAITRA, Anirban, OFFERHAUS, G. Johan A, SHIMIZU, Michio, YONEZAWA, Suguru, KLIMSTRA, David S, ADSAY, N. Volkan, ALBORES-SAAVEDRA, Jorge, BIANKIN, Andrew V, BIANKIN, Sandra A, COMPTON, Carolyn, FUKUSHIMA, Noriyoshi, FURUKAWA, Torn

“…Invasive pancreatic ductal adenocarcinoma is an almost uniformly fatal disease. Several distinct noninvasive precursor lesions can give rise to invasive…”
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Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds by KLEIN, Alison P, BRUNE, Kieran A, HRUBAN, Ralph H, PETERSEN, Gloria M, GOGGINS, Michael, TERSMETTE, Anne C, OFFERHAUS, G. Johan A, GRIFFIN, Constance, CAMERON, John L, YEA, Charles J, KERN, Scott

“…Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational…”
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Status of CHEK2 and p53 in patients with early-onset and conventional gastric cancer by Machlowska, Julita, Kapusta, Przemysław, Szlendak, Małgorzata, Bogdali, Anna, Morsink, Folkert, Wołkow, Paweł, Maciejewski, Ryszard, Offerhaus, G Johan A, Sitarz, Robert

“…Gastric cancer (GC) is the fourth most common cause of cancer-associated death. Based on the age at diagnosis, GC is divided into early-onset GC (EOGC; ≤45…”
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Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance by Korsse, Susanne E, Harinck, Femme, van Lier, Margot G F, Biermann, Katharina, Offerhaus, G Johan A, Krak, Nanda, Looman, Caspar W N, van Veelen, Wendy, Kuipers, Ernst J, Wagner, Anja, Dekker, Evelien, Mathus-Vliegen, Elisabeth M H, Fockens, Paul, van Leerdam, Monique E, Bruno, Marco J

“…Although Peutz-Jeghers syndrome (PJS) is known to be associated with pancreatic cancer (PC), estimates of this risk differ widely. This hampers counselling of…”
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Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas by Hackeng, Wenzel M., Schelhaas, Willemien, Morsink, Folkert H. M., Heidsma, Charlotte M., van Eeden, Susanne, Valk, Gerlof D., Vriens, Menno R., Heaphy, Christopher M., Nieveen van Dijkum, Els J. M., Offerhaus, G. Johan A., Dreijerink, Koen M. A., Brosens, Lodewijk A. A.

“…Insulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally considered to be indolent tumors with an excellent prognosis after…”
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Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study by Al-Janabi, Shaimaa, MD, Huisman, André, PhD, Vink, Aryan, MD, PhD, Leguit, Roos J., MD, Offerhaus, G. Johan A., MD, PhD, ten Kate, Fiebo J.W., MD, PhD, van Diest, Paul J., MD, PhD

“…Summary During the last decade, whole slide images have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation,…”
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The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers by Kodach, Liudmila L, Wiercinska, Eliza, de Miranda, Noel F.C.C, Bleuming, Sylvia A, Musler, Alex R, Peppelenbosch, Maikel P, Dekker, Evelien, van den Brink, Gijs R, van Noesel, Carel J.M, Morreau, Hans, Hommes, Daniel W, ten Dijke, Peter, Offerhaus, G. Johan A, Hardwick, James C.H

“…Background & Aims: The finding of bone morphogenetic protein (BMP) receptor 1a mutations in juvenile polyposis suggests that BMPs are important in colorectal…”
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Gastric cancer: epidemiology, prevention, classification, and treatment by Sitarz, Robert, Skierucha, Małgorzata, Mielko, Jerzy, Offerhaus, G Johan A, Maciejewski, Ryszard, Polkowski, Wojciech P

“…Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of…”
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Correction: BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2 by Kestens, Christine, Siersema, Peter D, Offerhaus, G Johan A, van Baal, Jantine W P M

“…[This corrects the article DOI: 10.1371/journal.pone.0155754.]…”
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