Search Results - "G. Goya, Rodolfo"

Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats by Pardo, Joaquín, Uriarte, Maia, Cónsole, Gloria M., Reggiani, Paula C., Outeiro, Tiago F., Morel, Gustavo R., Goya, Rodolfo G.

“…In rats, learning and memory performance decline during aging, which makes this rodent species a suitable model to evaluate therapeutic strategies of potential…”
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Magnetic field-assisted gene delivery: achievements and therapeutic potential by Schwerdt, Jose I, Goya, Gerardo F, Calatayud, M Pilar, Hereñú, Claudia B, Reggiani, Paula C, Goya, Rodolfo G

“…The discovery in the early 2000's that magnetic nanoparticles (MNPs) complexed to nonviral or viral vectors can, in the presence of an external magnetic field,…”
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Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders by Chiavellini, Priscila, Canatelli-Mallat, Martina, Lehmann, Marianne, Goya, Rodolfo, Morel, Gustavo

“…Hippocampus serves as a pivotal role in cognitive and emotional processes, as well as in the regulation of the hypothalamus-pituitary axis. It is known to…”
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Rejuvenation by cell reprogramming: a new horizon in gerontology by Goya, Rodolfo G, Lehmann, Marianne, Chiavellini, Priscila, Canatelli-Mallat, Martina, Hereñú, Claudia B, Brown, Oscar A

“…The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation…”
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A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation by Ogundele, Olalekan M, Pardo, Joaquin, Francis, Joseph, Goya, Rodolfo G, Lee, Charles C

“…Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation,…”
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Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide by Bellini, Maria J, Hereñú, Claudia B, Goya, Rodolfo G, Garcia-Segura, Luis M

“…Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation…”
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Physiology and therapeutic potential of the thymic peptide thymulin by Reggiani, Paula C, Schwerdt, Jose I, Console, Gloria M, Roggero, Eduardo A, Dardenne, Mireille, Goya, Rodolfo G

“…Thymulin is a thymic hormone exclusively produced by the epithelial cells of the thymus. After its discovery and initial characterization in the '70s, it was…”
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Increased number of neurons in the cervical spinal cord of aged female rats by Portiansky, Enrique L, Nishida, Fabian, Barbeito, Claudio G, Gimeno, Eduardo J, Goya, Rodolfo G

“…In the brain, specific signaling pathways localized in highly organized regions called niches allow the persistence of a pool of stem and progenitor cells that…”
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Gene therapy and cell reprogramming for the aging brain: achievements and promise by Pardo, Joaquín, Morel, Gustavo R, Astiz, Mariana, Schwerdt, José I, León, Micaela L, Rodríguez, Silvia S, Hereñú, Claudia B, Goya, Rodolfo G

“…In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the…”
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A HIERARCHICAL MODEL FOR THE CONTROL OF EPIGENETIC AGING IN MAMMALS by Lehmann, Marianne, Canatelli-Mallat, Martina, Chiavellini, Priscila, Goya, Rodolfo G.

“…Graphic summary of proposed hierarchical model for the control of the epigenetic clock in mammals. [Display omitted] •Emerging evidence suggests that aging is…”
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Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging by Morel, Gustavo R., León, Micaela López, Uriarte, Maia, Reggiani, Paula C., Goya, Rodolfo G.

“…In rats, learning and memory performance decline during normal aging, which is paralleled by a severe reduction of the levels of neurogenesis in the…”
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Hippocampal DNA Methylation, Epigenetic Age, and Spatial Memory Performance in Young and Old Rats by Chiavellini, Priscila, Lehmann, Marianne, Canatelli Mallat, Martina, Zoller, Joseph A, Herenu, Claudia B, Morel, Gustavo R, Horvath, Steve, Goya, Rodolfo G

“…In humans and rats, aging is associated with a progressive deterioration of spatial learning and memory. These functional alterations are correlated with…”
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Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain by López-León, Micaela, Outeiro, Tiago F, Goya, Rodolfo G

“…Aging is associated with a progressive increase in the incidence of neurodegenerative diseases, with Alzheimer's (AD) and Parkinson's (PD) disease being the…”
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Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats by Chiavellini, Priscila, Lehmann, Marianne, Gallardo, Maria D, Mallat, Martina Canatelli, Pasquini, Diana C, Zoller, Joseph A, Gordevicius, Juozas, Girard, Mauricio, Lacunza, Ezequiel, Herenu, Claudia B, Horvath, Steve, Goya, Rodolfo G

“…Abstract There is converging evidence that young blood conveys cells, vesicles, and molecules able to revitalize function and restore organ integrity in old…”
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The Emerging View of Aging as a Reversible Epigenetic Process by López-León, Micaela, Goya, Rodolfo G

“…The achievement of animal cloning and subsequent development of cell reprogramming technology are having a profound impact on our view of the mechanisms of…”
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Regional research priorities in brain and nervous system disorders by Ravindranath, Vijayalakshmi, Dang, Hoang-Minh, Goya, Rodolfo G., Mansour, Hader, Nimgaonkar, Vishwajit L., Russell, Vivienne Ann, Xin, Yu

“…The characteristics of neurological, psychiatric, developmental and substance-use disorders in low- and middle-income countries are unique and the burden that…”
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Aging and rejuvenation - a modular epigenome model by Chiavellini, Priscila, Canatelli-Mallat, Martina, Lehmann, Marianne, Gallardo, Maria D, Herenu, Claudia B, Cordeiro, Jose L, Clement, James, Goya, Rodolfo G

“…The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only…”
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IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function by Pardo, Joaquín, Abba, Martin C, Lacunza, Ezequiel, Ogundele, Olalekan M, Paiva, Isabel, Morel, Gustavo R, Outeiro, Tiago F, Goya, Rodolfo G

“…In rats, learning and memory performance decline during normal aging, which makes this rodent species a suitable model to evaluate therapeutic strategies. In…”
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Identification of a conserved gene signature associated with an exacerbated inflammatory environment in the hippocampus of aging rats by Pardo, Joaquín, Abba, Martin C., Lacunza, Ezequiel, Francelle, Laetitia, Morel, Gustavo R., Outeiro, Tiago F., Goya, Rodolfo G.

“…ABSTRACT There have been a few descriptive studies in aged rodents about transcriptome changes in the hippocampus, most of them in males. Here, we assessed the…”
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A regulatable adenovector system for GDNF and GFP delivery in the rat hippocampus by Coll, Lucía, Rodriguez, Silvia S., Goya, Rodolfo G., Morel, Gustavo R.

“…Spatial memory performance declines in both normal aging and Alzheimer's disease. This cognitive deficit is related to hippocampus dysfunction. Gene therapy…”
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