Search Results - "G N Wogan"

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice by Erdman, S.E, Rao, V.P, Poutahidis, T, Rogers, A.B, Taylor, C.L, Jackson, E.A, Ge, Z, Lee, C.W, Schauer, D.B, Wogan, G.N, Tannenbaum, S.R, Fox, J.G

“…Recombinase-activating gene-2-deficient (Rag2⁻/⁻) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating…”
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Chemistry meets biology in colitis-associated carcinogenesis by Mangerich, A, Dedon, P C, Fox, J G, Tannenbaum, S R, Wogan, G N

“…The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and…”
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Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer by Wang, C, Gong, G, Sheh, A, Muthupalani, S, Bryant, E M, Puglisi, D A, Holcombe, H, Conaway, E A, Parry, N A P, Bakthavatchalu, V, Short, S P, Williams, C S, Wogan, G N, Tannenbaum, S R, Fox, J G, Horwitz, B H

“…The risk of colon cancer is increased in patients with Crohn’s disease and ulcerative colitis. Inflammation-induced DNA damage could be an important link…”
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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology by Kensler, Thomas W, Roebuck, Bill D, Wogan, Gerald N, Groopman, John D

“…Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically…”
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Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma by Ross, R K, Yuan, J M, Yu, M C, Wogan, G N, Qian, G S, Tu, J T, Groopman, J D, Gao, Y T, Henderson, B E

“…Aflatoxins have long been suspected to be human hepatic carcinogens but no direct study was feasible until assays to measure individual aflatoxin exposure…”
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Aflatoxin as a human carcinogen by Wogan, Gerald N.

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Aflatoxins as risk factors for hepatocellular carcinoma in humans by WOGAN, G. N

“…On a global basis, primary liver cancer (PLC) is a very prevalent form of cancer. Wide variation of PLC incidence in different areas of the world suggests the…”
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Monocyclic aromatic amines as potential human carcinogens: old is new again by Skipper, Paul L., Kim, Min Young, Sun, H.-L. Patty, Wogan, Gerald N., Tannenbaum, Steven R.

“…Alkylanilines are a group of chemicals whose ubiquitous presence in the environment is a result of the multitude of sources from which they originate. Exposure…”
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The TPR-MET Oncogenic Rearrangement is Present and Expressed in Human Gastric Carcinoma and Precursor Lesions by Soman, Neela R., Correa, Pelayo, Ruiz, Bernardo A., Wogan, Gerald N.

“…The TPR-MET oncogenic rearrangement was originally observed in an in vitro transformed human osteosarcoma cell line. Recently, we detected the expression of…”
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Molecular Epidemiology in Cancer Risk Assessment and Prevention: Recent Progress and Avenues for Future Research by Wogan, Gerald N.

“…Molecular epidemiology is increasingly being applied in studies of cancer risks derived from exposure to environmental carcinogens of both endogenous and…”
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Environmental and chemical carcinogenesis by Wogan, Gerald N., Hecht, Stephen S., Felton, James S., Conney, Allan H., Loeb, Lawrence A.

“…People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental…”
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Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide by NAIR, J, GAL, A, TAMIR, S, TANNENBAUM, S. R, WOGAN, G. N, BARTSCH, H

“…In order to investigate specific DNA damage caused by nitric oxide (NO) induced lipid peroxidation, levels of promutagenic etheno adducts…”
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Characterization of c-Ki-ras Oncogene Alleles by Direct Sequencing of Enzymatically Amplified DNA from Carcinogen-Induced Tumors by McMahon, Gerald, Davis, Elaine, Wogan, Gerald N.

“…Activated c-Ki-ras genes in liver tumors from rats exposed to the potent hepatocarcinogen aflatoxin B1 were analyzed to determine the nature of their…”
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Characterization of c-Ki-ras and N-ras Oncogenes in Aflatoxin B1- Induced Rat Liver Tumors by McMahon, Gerald, Davis, Elaine F., Huber, L. Julie, Kim, Youngsoo, Wogan, Gerald N.

“…c-Ki-ras and N-ras oncogenes have been characterized in aflatoxin B1-induced hepatocellular carcinomas. Detection of different protooncogene and oncogene…”
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Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans by Groopman, J.D, Wild, C.P, Hasler, J, Junshi, C, Wogan, G.N, Kensler, T.W

“…Human epidemiology and experimental animal data have provided the statistical association and biological information necessary to propose that aflatoxins are…”
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Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in guangxi autonomous region, people's republic in China by GROOPMAN, J. D, ZHU JIAQI, DONAHUE, P. R.K, PIKUL, A, LISHENG, Z, JUN-SHI, C, WOGAN, G. N

“…Hepatocellular carcinoma is one of the five leading human cancers causing at least 250,000 deaths each year. One of the major risk factors for this disease is…”
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Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa by Wild, C P, Hudson, G J, Sabbioni, G, Chapot, B, Hall, A J, Wogan, G N, Whittle, H, Montesano, R, Groopman, J D

“…Aflatoxin is implicated as a risk factor for hepatocellular carcinoma in areas of the world with a high incidence of this tumor. The present study was designed…”
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Activation of the c-Ki-ras Oncogene in Aflatoxin B1-Induced Hepatocellular Carcinoma and Adenoma in the Rat: Detection by Denaturing Gradient Gel Electrophoresis by Soman, Neela R., Wogan, Gerald N.

“…Sequence alterations in the exon 1 region of the rat c-Ki-ras gene were studied in DNA isolated from aflatoxin B1(AFB1)-induced rat liver carcinomas and…”
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Nitrotyrosine formation, apoptosis, and oxidative damage : Relationships to nitric oxide production in SJL mice bearing the RcsX tumor by GAL, A, TAMIR, S, KENNEDY, L. J, TANNENBAUM, S. R, WOGAN, G. N

“…In SJL mice, growth of RcsX lymphoma cells results in activation of macrophages in the spleen and lymph nodes to produce high levels of NO radical (NO.). We…”
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Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium by Zhuang, John C., Wright, Teresa L., deRojas-Walker, Teresa, Tannenbaum, Steven R., Wogan, Gerald N.

“…Characterization of mutations induced by NO in different experimental systems will facilitate elucidation of mechanisms underlying its genotoxicity. The…”
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