Search Results - "G Hengstler, Jan"

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis by Frey, Olivier, Misun, Patrick M., Fluri, David A., Hengstler, Jan G., Hierlemann, Andreas

“…Integration of multiple three-dimensional microtissues into microfluidic networks enables new insights in how different organs or tissues of an organism…”
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The ascending pathophysiology of cholestatic liver disease by Jansen, Peter L.M., Ghallab, Ahmed, Vartak, Nachiket, Reif, Raymond, Schaap, Frank G., Hampe, Jochen, Hengstler, Jan G.

“…In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary sclerosing cholangitis (PSC),…”
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Adverse outcome pathways: a concise introduction for toxicologists by Vinken, Mathieu, Knapen, Dries, Vergauwen, Lucia, Hengstler, Jan G., Angrish, Michelle, Whelan, Maurice

“…Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic representation of critical toxicological effects that propagate over different…”
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Cholestasis‐induced adaptive remodeling of interlobular bile ducts by Vartak, Nachiket, Damle‐Vartak, Amruta, Richter, Beate, Dirsch, Olaf, Dahmen, Uta, Hammad, Seddik, Hengstler, Jan G.

“…Cholestasis is a common complication in liver diseases that triggers a proliferative response of the biliary tree. Bile duct ligation (BDL) is a frequently…”
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Natural Killer Cells and Liver Fibrosis by Fasbender, Frank, Widera, Agata, Hengstler, Jan G, Watzl, Carsten

“…In the 40 years since the discovery of natural killer (NK) cells, it has been well established that these innate lymphocytes are important for early and…”
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Adverse outcome pathways: opportunities, limitations and open questions by Leist, Marcel, Ghallab, Ahmed, Graepel, Rabea, Marchan, Rosemarie, Hassan, Reham, Bennekou, Susanne Hougaard, Limonciel, Alice, Vinken, Mathieu, Schildknecht, Stefan, Waldmann, Tanja, Danen, Erik, van Ravenzwaay, Ben, Kamp, Hennicke, Gardner, Iain, Godoy, Patricio, Bois, Frederic Y., Braeuning, Albert, Reif, Raymond, Oesch, Franz, Drasdo, Dirk, Höhme, Stefan, Schwarz, Michael, Hartung, Thomas, Braunbeck, Thomas, Beltman, Joost, Vrieling, Harry, Sanz, Ferran, Forsby, Anna, Gadaleta, Domenico, Fisher, Ciarán, Kelm, Jens, Fluri, David, Ecker, Gerhard, Zdrazil, Barbara, Terron, Andrea, Jennings, Paul, van der Burg, Bart, Dooley, Steven, Meijer, Annemarie H., Willighagen, Egon, Martens, Marvin, Evelo, Chris, Mombelli, Enrico, Taboureau, Olivier, Mantovani, Alberto, Hardy, Barry, Koch, Bjorn, Escher, Sylvia, van Thriel, Christoph, Cadenas, Cristina, Kroese, D., van de Water, Bob, Hengstler, Jan G.

“…Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic…”
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MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes by Chaudhari, Umesh, Nemade, Harshal, Gaspar, John Antonydas, Hescheler, Jürgen, Hengstler, Jan G., Sachinidis, Agapios

“…An in depth investigation at the genomic level is needed to identify early human-relevant cardiotoxicity biomarkers that are induced by drugs and environmental…”
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Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood by Ghallab, Ahmed, Hofmann, Ute, Sezgin, Selahaddin, Vartak, Nachiket, Hassan, Reham, Zaza, Ayham, Godoy, Patricio, Schneider, Kai Markus, Guenther, Georgia, Ahmed, Yasser A., Abbas, Aya A., Keitel, Verena, Kuepfer, Lars, Dooley, Steven, Lammert, Frank, Trautwein, Christian, Spiteller, Michael, Drasdo, Dirk, Hofmann, Alan F., Jansen, Peter L.M., Hengstler, Jan G., Reif, Raymond

“…Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease. One of the early consequences of BDL in rodents is the…”
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Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity by Köppert, Sina, Büscher, Andrea, Babler, Anne, Ghallab, Ahmed, Buhl, Eva M, Latz, Eicke, Hengstler, Jan G, Smith, Edward R, Jahnen-Dechent, Willi

“…The liver-derived plasma protein fetuin-A is a systemic inhibitor of ectopic calcification. Fetuin-A stabilizes saturated mineral solutions by forming…”
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Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration by Hoehme, Stefan, Brulport, Marc, Bauer, Alexander, Bedawy, Essam, Schormann, Wiebke, Hermes, Matthias, Puppe, Verena, Gebhardt, Rolf, Zellmer, Sebastian, Schwarz, Michael, Bockamp, Ernesto, Timmel, Tobias, Hengstler, Jan G, Drasdo, Dirk

“…Only little is known about how cells coordinately behave to establish functional tissue structure and restore microarchitecture during regeneration. Research…”
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Rab5 is necessary for the biogenesis of the endolysosomal system in vivo by Zeigerer, Anja, Gilleron, Jerome, Bogorad, Roman L., Marsico, Giovanni, Nonaka, Hidenori, Seifert, Sarah, Epstein-Barash, Hila, Kuchimanchi, Satya, Peng, Chang Geng, Ruda, Vera M., Conte-Zerial, Perla Del, Hengstler, Jan G., Kalaidzidis, Yannis, Koteliansky, Victor, Zerial, Marino

“…An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of…”
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The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer by SCHMIDT, Marcus, BÖHM, Daniel, VON TÖRNE, Christian, STEINER, Eric, PUHL, Alexander, PILCH, Henryk, LEHR, Hans-Anton, HENGSTLER, Jan G, KÖLBL, Heinz, GEHRMANN, Mathias

“…Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional prognostic motifs,…”
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Biomarker Discovery in Non―Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation by BOTLING, Johan, EDLUND, Karolina, KÖNIG, André, FERNANDES, Oswaldo, KARLSSON, Mats, HELENIUS, Gisela, KARLSSON, Christina, RAHNENFÜHRER, Jörg, HENGSTLER, Jan G, MICKE, Patrick, LOHR, Miriam, HELLWIG, Birte, HOLMBERG, Lars, LAMBE, Mats, BERGLUND, Anders, EKMAN, Simon, BERGQVIST, Michael, PONTEN, Fredrik

“…Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict…”
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3D spherical microtissues and microfluidic technology for multi-tissue experiments and analysis by Kim, Jin-Young, Fluri, David A., Marchan, Rosemarie, Boonen, Kurt, Mohanty, Soumyaranjan, Singh, Prateek, Hammad, Seddik, Landuyt, Bart, Hengstler, Jan G., Kelm, Jens M., Hierlemann, Andreas, Frey, Olivier

“…•One-tissue format enables multiple tissue combinations on chip without design changes.•Tilting-based perfusion eliminates any tubing and ensures device…”
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Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation by Meisig, Johannes, Dreser, Nadine, Kapitza, Marion, Henry, Margit, Rotshteyn, Tamara, Rahnenführer, Jörg, Hengstler, Jan G, Sachinidis, Agapios, Waldmann, Tanja, Leist, Marcel, Blüthgen, Nils

“…Abstract Thousands of transcriptome data sets are available, but approaches for their use in dynamic cell response modelling are few, especially for processes…”
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Comparative analysis of 3D culture methods on human HepG2 cells by Luckert, Claudia, Schulz, Christina, Lehmann, Nadja, Thomas, Maria, Hofmann, Ute, Hammad, Seddik, Hengstler, Jan G., Braeuning, Albert, Lampen, Alfonso, Hessel, Stefanie

“…Human primary hepatocytes represent a gold standard in in vitro liver research. Due to their low availability and high costs alternative liver cell models with…”
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Comparing in vitro human liver models to in vivo human liver using RNA-Seq by Gupta, Rajinder, Schrooders, Yannick, Hauser, Duncan, van Herwijnen, Marcel, Albrecht, Wiebke, ter Braak, Bas, Brecklinghaus, Tim, Castell, Jose V., Elenschneider, Leroy, Escher, Sylvia, Guye, Patrick, Hengstler, Jan G., Ghallab, Ahmed, Hansen, Tanja, Leist, Marcel, Maclennan, Richard, Moritz, Wolfgang, Tolosa, Laia, Tricot, Tine, Verfaillie, Catherine, Walker, Paul, van de Water, Bob, Kleinjans, Jos, Caiment, Florian

“…The liver plays an important role in xenobiotic metabolism and represents a primary target for toxic substances. Many different in vitro cell models have been…”
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Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion‐Dominated Canalicular and Flow‐Augmented Ductular Bile Flux by Vartak, Nachiket, Guenther, Georgia, Joly, Florian, Damle‐Vartak, Amruta, Wibbelt, Gudrun, Fickel, Jörns, Jörs, Simone, Begher‐Tibbe, Brigitte, Friebel, Adrian, Wansing, Kasimir, Ghallab, Ahmed, Rosselin, Marie, Boissier, Noemie, Vignon‐Clementel, Irene, Hedberg, Christian, Geisler, Fabian, Hofer, Heribert, Jansen, Peter, Hoehme, Stefan, Drasdo, Dirk, Hengstler, Jan G.

“…Background and Aims Small‐molecule flux in tissue microdomains is essential for organ function, but knowledge of this process is scant due to the lack of…”
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations by Albrecht, Wiebke, Kappenberg, Franziska, Brecklinghaus, Tim, Stoeber, Regina, Marchan, Rosemarie, Zhang, Mian, Ebbert, Kristina, Kirschner, Hendrik, Grinberg, Marianna, Leist, Marcel, Moritz, Wolfgang, Cadenas, Cristina, Ghallab, Ahmed, Reinders, Jörg, Vartak, Nachiket, van Thriel, Christoph, Golka, Klaus, Tolosa, Laia, Castell, José V., Damm, Georg, Seehofer, Daniel, Lampen, Alfonso, Braeuning, Albert, Buhrke, Thorsten, Behr, Anne-Cathrin, Oberemm, Axel, Gu, Xiaolong, Kittana, Naim, van de Water, Bob, Kreiling, Reinhard, Fayyaz, Susann, van Aerts, Leon, Smedsrød, Bård, Ellinger-Ziegelbauer, Heidrun, Steger-Hartmann, Thomas, Gundert-Remy, Ursula, Zeigerer, Anja, Ullrich, Anett, Runge, Dieter, Lee, Serene M. L., Schiergens, Tobias S., Kuepfer, Lars, Aguayo-Orozco, Alejandro, Sachinidis, Agapios, Edlund, Karolina, Gardner, Iain, Rahnenführer, Jörg, Hengstler, Jan G.

“…Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the…”
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Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain by Salehinejad, Mohammad Ali, Ghanavati, Elham, Reinders, Jörg, Hengstler, Jan G, Kuo, Min-Fang, Nitsche, Michael A

“…Sleep strongly affects synaptic strength, making it critical for cognition, especially learning and memory formation. Whether and sleep deprivation modulates…”
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