Search Results - "Głuch‐Lutwin, Monika"

The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress by Głuch-Lutwin, Monika, Sałaciak, Kinga, Gawalska, Alicja, Jamrozik, Marek, Sniecikowska, Joanna, Newman-Tancredi, Adrian, Kołaczkowski, Marcin, Pytka, Karolina

“…Rationale The prevalence of depression is ever-increasing throughout the population. However, available treatments are ineffective in around one-third of…”
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The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling by Sałaciak, Kinga, Głuch-Lutwin, Monika, Siwek, Agata, Szafarz, Małgorzata, Kazek, Grzegorz, Bednarski, Marek, Nowiński, Leszek, Mitchell, Emma, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Wesołowska, Anna, Kołaczkowski, Marcin, Szkaradek, Natalia, Marona, Henryk, Sapa, Jacek, Pytka, Karolina

“…Background: Our previous studies showed that xanthone derivatives with N-(2-methoxyphenyl)piperazine fragment have an affinity to the 5-HT1A receptor and show…”
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Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2- a ]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action by Straszak, Dominik, Siwek, Agata, Głuch-Lutwin, Monika, Mordyl, Barbara, Kołaczkowski, Marcin, Pietrzak, Aldona, Rahnama-Hezavah, Mansur, Drop, Bartłomiej, Matosiuk, Dariusz

“…The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the…”
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Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity by Shabbir, Hasan, Wojtaszek, Konrad, Rutkowski, Bogdan, Csapó, Edit, Bednarski, Marek, Adamiec, Anita, Głuch-Lutwin, Monika, Mordyl, Barbara, Druciarek, Julia, Kotańska, Magdalena, Ozga, Piotr, Wojnicki, Marek

“…Carbon dots (CDs) are carbon-based zero-dimensional nanomaterials that can be prepared from a number of organic precursors. In this research, they are prepared…”
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Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors by Góral, Izabella, Wichur, Tomasz, Sługocka, Emilia, Godyń, Justyna, Szałaj, Natalia, Zaręba, Paula, Głuch-Lutwin, Monika, Mordyl, Barbara, Panek, Dawid, Więckowska, Anna

“…GSK-3β, IKK-β, and ROCK-1 kinases are implicated in the pathomechanism of Alzheimer's disease due to their involvement in the misfolding and accumulation of…”
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Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione by Góra, Małgorzata, Czopek, Anna, Rapacz, Anna, Dziubina, Anna, Głuch-Lutwin, Monika, Mordyl, Barbara, Obniska, Jolanta

“…The present study aimed to design and synthesize a new series of hybrid compounds with pyrrolidine-2,5-dione and thiophene rings in the structure as potential…”
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Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists by Partyka, Anna, Zagórska, Agnieszka, Kotańska, Magdalena, Walczak, Maria, Jastrzębska-Więsek, Magdalena, Knutelska, Joanna, Bednarski, Marek, Głuch-Lutwin, Monika, Mordyl, Barbara, Janiszewska, Paulina, Wesołowska, Anna

“…Current antidepressant therapy has several disadvantages related to the properties of antidepressants. Considering their unfavourable features, the process of…”
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Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors by Straszak, Dominik, Woźniak, Sylwia, Siwek, Agata, Głuch-Lutwin, Monika, Kołaczkowski, Marcin, Pietrzak, Aldona, Drop, Bartłomiej, Matosiuk, Dariusz

“…μ-opioid receptor ligands such as morphine and fentanyl are the most known and potent painkillers. However, the severe side effects seen with their use…”
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Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents by Żmudzka, Elżbieta, Lustyk, Klaudia, Głuch-Lutwin, Monika, Mordyl, Barbara, Zakrzewska-Sito, Alicja, Mierzejewski, Paweł, Jaśkowska, Jolanta, Kołaczkowski, Marcin, Sapa, Jacek, Pytka, Karolina

“…Schizophrenia is a chronic mental illness, which remains difficult to treat. A high resistance to the available therapies, their insufficient efficacy, and…”
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A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity by Dudek, Magdalena, Knutelska, Joanna, Bednarski, Marek, Nowiński, Leszek, Zygmunt, Małgorzata, Mordyl, Barbara, Głuch-Lutwin, Monika, Kazek, Grzegorz, Sapa, Jacek, Pytka, Karolina

“…The search for drugs with anorectic activity, acting within the adrenergic system has attracted the interest of researchers. Partial α2-adrenoceptor agonists…”
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Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models by Pytka, Karolina, Partyka, Anna, Jastrzębska-Więsek, Magdalena, Siwek, Agata, Głuch-Lutwin, Monika, Mordyl, Barbara, Kazek, Grzegorz, Rapacz, Anna, Olczyk, Adrian, Gałuszka, Adam, Błachuta, Marian, Waszkielewicz, Anna, Marona, Henryk, Sapa, Jacek, Filipek, Barbara, Wesołowska, Anna

“…The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives:…”
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Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives by Czopek, Anna, Partyka, Anna, Bucki, Adam, Pawłowski, Maciej, Kołaczkowski, Marcin, Siwek, Agata, Głuch-Lutwin, Monika, Koczurkiewicz, Paulina, Pękala, Elżbieta, Jaromin, Anna, Tyliszczak, Bożena, Wesołowska, Anna, Zagórska, Agnieszka

“…In this study, a series of compounds derived from 4-methoxy-1 -isoindole-1,3(2 )-dione, potential ligands of phosphodiesterase 10A and serotonin receptors,…”
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Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances by Kazek, Grzegorz, Głuch-Lutwin, Monika, Mordyl, Barbara, Menaszek, Elżbieta, Kubacka, Monika, Jurowska, Anna, Cież, Dariusz, Trzewik, Bartosz, Szklarzewicz, Janusz, Papież, Monika A

“…In the text, the synthesis and characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They…”
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Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors by Sałaciak, Kinga, Malikowska-Racia, Natalia, Lustyk, Klaudia, Siwek, Agata, Głuch-Lutwin, Monika, Kazek, Grzegorz, Popiół, Justyna, Sapa, Jacek, Marona, Henryk, Żelaszczyk, Dorota, Pytka, Karolina

“…The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As…”
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Novel Multimodal Salicylamide Derivative with Antidepressant-like, Anxiolytic-like, Antipsychotic-like, and Anti-Amnesic Activity in Mice by Żmudzka, Elżbieta, Lustyk, Klaudia, Głuch-Lutwin, Monika, Wolak, Małgorzata, Jaśkowska, Jolanta, Kołaczkowski, Marcin, Sapa, Jacek, Pytka, Karolina

“…Depression, anxiety, and schizophrenia may coexist in psychiatric patients. Moreover, these disorders are very often associated with cognitive impairments…”
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HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats by Pytka, Karolina, Głuch-Lutwin, Monika, Knutelska, Joanna, Jakubczyk, Magdalena, Waszkielewicz, Anna, Kotańska, Magdalena

“…Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our…”
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Xanthine-Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases by Załuski, Michał, Karcz, Tadeusz, Drabczyńska, Anna, Vielmuth, Christin, Olejarz-Maciej, Agnieszka, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Satała, Grzegorz, Müller, Christa E, Kieć-Kononowicz, Katarzyna

“…Multitarget drugs based on a hybrid dopamine-xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases…”
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HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling by Pytka, Karolina, Głuch-Lutwin, Monika, Żmudzka, Elżbieta, Sałaciak, Kinga, Siwek, Agata, Niemczyk, Katarzyna, Walczak, Maria, Smolik, Magdalena, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Filipek, Barbara, Sapa, Jacek, Kołaczkowski, Marcin, Pańczyk, Katarzyna, Waszkielewicz, Anna, Marona, Henryk

“…Numerous studies have proven that both stimulation and blockade of 5-HT 1A and the blockade of 5-HT 7 receptors might cause the anxiolytic-like effects. Biased…”
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Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities by Zagórska, Agnieszka, Partyka, Anna, Bucki, Adam, Kołaczkowski, Marcin, Jastrzębska‐Więsek, Magdalena, Czopek, Anna, Siwek, Agata, Głuch‐Lutwin, Monika, Bednarski, Marek, Bajda, Marek, Jończyk, Jakub, Piska, Kamil, Koczurkiewicz, Paulina, Wesołowska, Anna, Pawłowski, Maciej

“…A series of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione has been synthesized in an attempt to discover a new class…”
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Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT 1A /5-HT 7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity by Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Partyka, Anna, Wesołowska, Anna, Kazek, Grzegorz, Głuch-Lutwin, Monika, Siwek, Agata, Starowicz, Gabriela, Pawłowski, Maciej

“…In the search for potential psychotropic agents, a new series of 3,7-dimethyl- and 1,3-dimethyl-8-alkoxypurine-2,6-dione derivatives of arylpiperazines,…”
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