Search Results - "Głowala, Magdalena"
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Transcriptome Analysis of Cells Exposed to Actinomycin D and Nutlin-3a Reveals New Candidate p53-Target Genes and Indicates That CHIR-98014 Is an Important Inhibitor of p53 Activity
Published in International journal of molecular sciences (14-10-2021)“…Co-treatment with actinomycin D and nutlin-3a (A + N) strongly activates p53. Previously we reported that CHIR-98014 (GSK-3 kinase inhibitor), acting in cells…”
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Human Cardiac Mesenchymal Stromal Cells with CD105+CD34- Phenotype Enhance the Function of Post-Infarction Heart in Mice
Published in PloS one (01-07-2016)“…The aim of the present study was to isolate mesenchymal stromal cells (MSC) with CD105+CD34- phenotype from human hearts, and to investigate their therapeutic…”
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Establishment and Characterization of the Novel High-Grade Serous Ovarian Cancer Cell Line OVPA8
Published in International journal of molecular sciences (17-07-2018)“…High-grade serous ovarian carcinoma (HGSOC) is the most frequent histological type of ovarian cancer and the one with worst prognosis. Unfortunately, the…”
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Novel role for the testis‐enriched HSPA2 protein in regulating epidermal keratinocyte differentiation
Published in Journal of cellular physiology (01-03-2018)“…HSPA2, a poorly characterized member of the HSPA (HSP70) chaperone family, is a testis‐enriched protein involved in male germ cell differentiation. Previously,…”
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Association of circulating regulatory T cell number with the incidence and prognosis of diffuse large B-cell lymphoma
Published in European journal of haematology (01-08-2013)“…Regulatory T (Treg) cells are essential for maintaining immune tolerance. High Treg frequencies have been reported in peripheral blood and tissue samples of…”
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Anticancer effects of CAMEL peptide
Published in Laboratory investigation (01-06-2010)“…This study analyzed whether therapy with CAMEL, an antimicrobial peptide (KWKLFKKIGAVLKVL), possess anticancer benefits. Although the peptide was cytotoxic for…”
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Oligo-3-hydroxybutyrates as potential carriers for drug delivery
Published in Biomaterials (01-10-2004)“…In the present paper we describe the synthesis and toxicity studies of well-defined tailor made oligo-[ R, S]-3-hydroxybutyrates (OHBs). The results indicate…”
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Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand
Published in Apoptosis (London) (01-10-2024)“…The FAS ligand (FASLG) is expressed on lymphocytes, which employ it to activate death receptors on target cells. Cancer cells are generally resistant to…”
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Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity
Published in Cellular signalling (01-05-2020)“…Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N…”
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An Increase in HSF1 Expression Directs Human Mammary Epithelial Cells toward a Mesenchymal Phenotype
Published in Cancers (12-10-2023)“…HSF1 is a well-known heat shock protein expression regulator in response to stress. It also regulates processes important for growth, development or…”
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Evaluation of proinflammatory and immunosuppressive cytokines in blood and bone marrow of healthy hematopoietic stem cell donors
Published in Cytokine (Philadelphia, Pa.) (01-02-2018)“…•The first study comparing cytokine concentration, expression of CD47 and CD274 immunosuppressive proteins on HSCs in bone marrow and blood of hematopoietic…”
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HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells
Published in Cancers (01-10-2020)“…Heat Shock Protein A2 (HSPA2) is a member of the HSPA (HSP70) chaperone family and has a critical role for male fertility. HSPA2 is present in a number of…”
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Synthetic conjugates of genistein affecting proliferation and mitosis of cancer cells
Published in Bioorganic & medicinal chemistry (01-01-2011)“…This paper describes the synthesis and antiproliferative activity of conjugates of genistein (1) and unsaturated pyranosides. Constructs linking genistein with…”
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Legal and moral aspects of transplantation
Published in Journal of education, health and sport (01-10-2018)“…January 26, 1966 r. In the Department of Surgery, Medical University of Warsaw, a team of doctors in Poland made the first successful kidney transplant. It was…”
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Legal and moral aspects of transplantation
Published in Journal of education, health and sport (01-10-2018)“…January 26, 1966 r. In the Department of Surgery, Medical University of Warsaw, a team of doctors in Poland made the first successful kidney transplant. It was…”
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Synthesis and antiproliferative properties of ibuprofen–oligo(3-hydroxybutyrate) conjugates
Published in European journal of medicinal chemistry (01-05-2010)“…Synthesis of novel conjugates of the non-steroidal anti-inflammatory drug – ibuprofen with nontoxic oligo(3-hydroxybutyrate) (OHB) is described. Presented…”
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Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubules
Published in Bioorganic & medicinal chemistry letters (01-09-2009)“…Novel genistein derivative 7- O-(2,3,4,6-tetra- O-acetyl-β- d-galactopyranosyl)-(1→4)-(6- O-acetyl-hex-2-ene-α- d-erythropyranosyl) genistein, shortly named…”
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Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol
Published in Molecular biology reports (01-08-2013)“…Resveratrol is a natural compound that has been intensely studied due to its role in cancer prevention and potential as an anti-cancer therapy. Its effects…”
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Overexpression of Heat Shock Transcription Factor 1 enhances the resistance of melanoma cells to doxorubicin and paclitaxel
Published in BMC cancer (29-10-2013)“…Heat Shock Transcription Factor 1 (HSF1) is activated under stress conditions. In turn, it induces expression of Heat Shock Proteins (HSPs), which are…”
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High resolution proton nuclear magnetic resonance (1H NMR) spectroscopy of surviving C6 glioma cells after X-ray irradiation
Published in Folia neuropathologica (2013)“…To study biochemical response of living model of glioma to X-rays irradiation using high resolution proton nuclear magnetic resonance (1H NMR) spectroscopy…”
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